Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo (Q30576918)

22 August 2017

Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo (English)

1 reference

22 August 2017

hepatocellular carcinoma

1 reference

8

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11 June 2020

Gautam Sethi

1

1 reference

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11 June 2020

Peramaiyan Rajendran

3

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11 June 2020

Kam M Hui

10

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11 June 2020

John M. Luk

13

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11 June 2020

author name string

Snehajyoti Chatterjee

2

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11 June 2020

Feng Li

4

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11 June 2020

Muthu K Shanmugam

5

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11 June 2020

Kwong Fai Wong

6

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11 June 2020

Alan Prem Kumar

7

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11 June 2020

Amit K Behera

9

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11 June 2020

Jeelan Basha

11

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11 June 2020

Nagashayana Natesh

12

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11 June 2020

Tapas K Kundu

14

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11 June 2020

publication date

21 March 2014

1 reference

22 August 2017

1 reference

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11 June 2020

volume

13

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11 June 2020

page(s)

66

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Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3

11 June 2020

cites work

1 reference

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Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells

20 June 2018

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Potential role of signal transducer and activator of transcription (STAT)3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinoma

20 June 2018

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Anticancer action of garcinol in vitro and in vivo is in part mediated through inhibition of STAT-3 signaling

20 June 2018

1 reference

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Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation.

20 June 2018

1 reference

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High expression of p300 in HCC predicts shortened overall survival in association with enhanced epithelial mesenchymal transition of HCC cells

20 June 2018

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Garcinol-induced apoptosis in prostate and pancreatic cancer cells is mediated by NF- kappaB signaling.

20 June 2018

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Celecoxib inhibits interleukin-6/interleukin-6 receptor-induced JAK2/STAT3 phosphorylation in human hepatocellular carcinoma cells

20 June 2018

1 reference

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Garcinol inhibits cell proliferation and promotes apoptosis in pancreatic adenocarcinoma cells

20 June 2018

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Cancer chemoprevention by targeting the epigenome.

20 June 2018

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Fluorinated 2'-hydroxychalcones as garcinol analogs with enhanced antioxidant and anticancer activities

20 June 2018

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Garcinol potentiates TRAIL-induced apoptosis through modulation of death receptors and antiapoptotic proteins

20 June 2018

1 reference

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Nicotine-induced human breast cancer cell proliferation attenuated by garcinol through down-regulation of the nicotinic receptor and cyclin D3 proteins.

20 June 2018

1 reference

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Apoptosis-inducing effect of garcinol is mediated by NF-kappaB signaling in breast cancer cells

20 June 2018

1 reference

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Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs

20 June 2018

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Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship?.

20 June 2018

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Combination chemotherapy of doxorubicin and paclitaxel for hepatocellular carcinoma in vitro and in vivo.

20 June 2018

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Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors

20 June 2018

1 reference

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Management of advanced hepatocellular carcinoma in the era of targeted therapy

20 June 2018

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Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells

20 June 2018

1 reference

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STAT 3 as a target for cancer drug discovery

20 June 2018

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Interleukin-6 mediates G(0)/G(1) growth arrest in hepatocellular carcinoma through a STAT 3-dependent pathway

20 June 2018

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Effects of garcinol and its derivatives on intestinal cell growth: Inhibitory effects and autoxidation-dependent growth-stimulatory effects

20 June 2018

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Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution

20 June 2018

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Hepatitis B virus-induced oncogenesis.

20 June 2018

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Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells

20 June 2018

1 reference

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Dietary garcinol inhibits 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in rats

20 June 2018

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Stat3 dimerization regulated by reversible acetylation of a single lysine residue

20 June 2018

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Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression

20 June 2018

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Focus on hepatocellular carcinoma.

20 June 2018

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Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma

20 June 2018

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20 June 2018

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Prevention of colonic aberrant crypt foci by dietary feeding of garcinol in male F344 rats

20 June 2018

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20 June 2018

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Three-dimensional structure of the Stat3beta homodimer bound to DNA

20 June 2018

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20 June 2018

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STATs: signal transducers and activators of transcription

20 June 2018

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A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6.

20 June 2018

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Current management strategy of hepatocellular carcinoma

20 June 2018

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Mechanism of p300 specific histone acetyltransferase inhibition by small molecules

21 January 2018

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The bactericidal effects of Lactobacillus acidophilus, garcinol and Protykin compared to clarithromycin, on Helicobacter pylori

21 January 2018

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Effects of garcinol on free radical generation and NO production in embryonic rat cortical neurons and astrocytes

21 January 2018

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Modulation of arachidonic acid metabolism and nitric oxide synthesis by garcinol and its derivatives

21 January 2018

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Celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade in vitro and in vivo

21 January 2018

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Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation

21 January 2018

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Nitric Oxide-Mediated Histone Hyperacetylation in Oral Cancer: Target for a Water-Soluble HAT Inhibitor, CTK7A

21 January 2018

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Specific inhibition of p300-HAT alters global gene expression and represses HIV replication.

21 January 2018

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Garcinol, a polyisoprenylated benzophenone modulates multiple proinflammatory signaling cascades leading to the suppression of growth and survival of head and neck carcinoma

21 January 2018

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Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells.

21 January 2018

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Free radical scavenging activity and antiulcer activity of garcinol from Garcinia indica fruit rind

21 January 2018

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12 December 2020

Rising incidence of hepatocellular carcinoma in the United States

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12 December 2020

Stress activated protein kinase p38 is involved in IL-6 induced transcriptional activation of STAT3

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12 December 2020

Suppression of signal transducer and activator of transcription 3 activation by butein inhibits growth of human hepatocellular carcinoma in vivo

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12 December 2020

Identifiers

DOI

10.1186/1476-4598-13-66

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24655440%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

11 June 2020

0 references

1 reference

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11 June 2020

PubMed publication ID

24655440

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24655440%20AND%20SRC:MED&resulttype=core&format=json