Is schizophrenia a neurodegenerative disorder? A clinical and neurobiological perspective (Q30581772)

25 June 2017

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title

Is schizophrenia a neurodegenerative disorder? A clinical and neurobiological perspective (English)

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25 June 2017

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Lieberman JA

1

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PubMed ID

10494440

25 June 2017

language of work or name

English

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publication date

1 September 1999

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25 June 2017

Biological Psychiatry

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25 June 2017

46

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25 June 2017

6

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25 June 2017

729-739

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Absence of neurodegeneration and neural injury in the cerebral cortex in a sample of elderly patients with schizophrenia.

25 June 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Childhood behavioral precursors of adult symptom dimensions in schizophrenia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Intellectual deficits in first-episode schizophrenia: evidence for progressive deterioration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Advancing a neurodevelopmental origin for schizophrenia

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Recent advances in the neuropathology of schizophrenia

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Frontostriatal disorder of cerebral metabolism in never-medicated schizophrenics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Striatal metabolic rate and clinical response to neuroleptics in schizophrenia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Increased frontal and reduced parietal glucose metabolism in acute untreated schizophrenia

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Oxidative stress, glutamate, and neurodegenerative disorders

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Severity of symptoms in chronically institutionalized geriatric schizophrenic patients.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Ventricular enlargement in poor-outcome schizophrenia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

A prospective follow-up study of brain morphology and cognition in first-episode schizophrenic patients: preliminary findings

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Childhood antecedents of schizophrenia and affective illness: social adjustment at ages 7 and 11

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Antecedents, symptom progression, and long-term outcome of the deficit syndrome in schizophrenia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Absence of activation in frontal structures during psychological testing of chronic schizophrenics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Brain anatomic magnetic resonance imaging in childhood-onset schizophrenia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Functional and anatomical aspects of prefrontal pathology in schizophrenia

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Minor physical anomalies in schizophrenia patients, bipolar patients, and their siblings

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

A follow-up magnetic resonance imaging study of schizophrenia. Relationship of neuroanatomical changes to clinical and neurobehavioral measures.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Genetic classification of primary neurodegenerative disease.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

The changing content of psychiatric illness.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Neuropsychological deficits in schizophrenics. Relationship to age, chronicity, and dementia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

One hundred years of schizophrenia: a meta-analysis of the outcome literature.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Neuropsychological functioning of first-episode schizophreniform patients

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

The membrane hypothesis of schizophrenia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Longitudinal studies of schizophrenic patients

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Stability of CT scan findings in schizophrenia: results of an 8 year follow-up study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Cerebral ventricular enlargement in schizophreniform disorder does not progress. A seven year follow-up study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Child development risk factors for adult schizophrenia in the British 1946 birth cohort

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Ventricle-to-brain ratio in schizophrenia: a controlled follow-up study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

The genetics of schizophrenia: a current, genetic-epidemiologic perspective

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Changes in caudate volume with neuroleptic treatment

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Temporal lobe sulco-gyral pattern anomalies in schizophrenia: an in vivo MR three-dimensional surface rendering study.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Heterogeneity of the psychoses: is there a neurodegenerative psychosis?

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Development of the prefrontal cortex during adolescence: insights into vulnerable neural circuits in schizophrenia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Qualitative assessment of brain morphology in acute and chronic schizophrenia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Psychobiologic correlates of treatment response in schizophrenia

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Neurochemical sensitization in the pathophysiology of schizophrenia: deficits and dysfunction in neuronal regulation and plasticity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

The development of treatment resistance in patients with schizophrenia: a clinical and pathophysiologic perspective

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Duration of psychosis and outcome in first-episode schizophrenia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Oxygen radicals and neuropsychiatric illness. Some speculations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Programmed cell death: implications for neuropsychiatric disorders

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Evidence for synaptic apoptosis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Abnormal movements in never-medicated Indian patients with schizophrenia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

A selective review of recent North American long-term followup studies of schizophrenia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Subtype progression and pathophysiologic deterioration in early schizophrenia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Changes in subtype diagnosis of schizophrenia: 1920-1966.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Is schizophrenia a neurodevelopmental disorder?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Cerebral ventricular enlargement in schizophrenia. A preliminary follow-up study.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Glutamate receptor dysfunction and schizophrenia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Spontaneous involuntary disorders of movement: their prevalence, severity, and distribution in chronic schizophrenics with and without treatment with neuroleptics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Alterations in brain high-energy phosphate and membrane phospholipid metabolism in first-episode, drug-naive schizophrenics. A pilot study of the dorsal prefrontal cortex by in vivo phosphorus 31 nuclear magnetic resonance spectroscopy.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

The evolution of symptoms in institutionalized hebephrenic/catatonic schizophrenics.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Alzheimer disease and related neurodegenerative diseases in elderly patients with schizophrenia: a postmortem neuropathologic study of 100 cases.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Neuronal and glial somal size in the prefrontal cortex: a postmortem morphometric study of schizophrenia and Huntington disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Childhood-onset schizophrenia. Progressive ventricular change during adolescence.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Progressive cortical change during adolescence in childhood-onset schizophrenia. A longitudinal magnetic resonance imaging study.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Free radical pathology in schizophrenia: a review

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Is there gliosis in schizophrenia? Investigation of the temporal lobe.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Neuropsychological deficits in neuroleptic naive patients with first-episode schizophrenia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Course of treatment response in first-episode and chronic schizophrenia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

An in vivo study of the prefrontal cortex of schizophrenic patients at different stages of illness via phosphorus magnetic resonance spectroscopy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

An in vivo proton magnetic resonance spectroscopy study of schizophrenia patients

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Effect of neuroleptics on altered cerebral glucose metabolism in schizophrenia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Brain morphology in schizophrenia: a 2- to 5-year CT scan follow-up study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

CT scan abnormalities and outcome of chronic schizophrenia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Developmental trajectory and disease progression in schizophrenia: the conundrum, and insights from a 12-year prospective study in the Monaghan 101.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Sequential cross-sectional and 10-year prospective study of severe negative symptoms in relation to duration of initially untreated psychosis in chronic schizophrenia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Neuromotor precursors of schizophrenia

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

From neuropathology to neurodevelopment

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Implications of normal brain development for the pathogenesis of schizophrenia

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Is schizophrenia a progressive neurodevelopmental disorder? Toward a unitary pathogenetic mechanism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Progressive ventricular enlargement in schizophrenia: comparison to bipolar affective disorder and correlation with clinical course

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900147-X

Neuroleptics and the Natural Course of Schizophrenia

7 January 2021

1 reference

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Early intervention for schizophrenia: can the course of the illness be altered?

7 January 2021

1 reference

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10.1016/S0006-3223(99)00147-X

7 January 2021

Identifiers

DOI

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25 June 2017

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PubMed ID

10494440