HTS in the new millennium: the role of pharmacology and flexibility (Q30660945)

26 June 2017

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title

HTS in the new millennium: the role of pharmacology and flexibility (English)

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26 June 2017

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Landro JA

1

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26 June 2017

Taylor IC

2

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26 June 2017

Stirtan WG

3

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26 June 2017

Osterman DG

4

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26 June 2017

Kristie J

5

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26 June 2017

Hunnicutt EJ

6

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26 June 2017

Rae PM

7

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26 June 2017

Sweetnam PM

8

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26 June 2017

publication date

1 July 2000

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Journal of Pharmacological and Toxicological Methods

26 June 2017

published in

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26 June 2017

volume

44

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26 June 2017

issue

1

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26 June 2017

page(s)

273-289

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Can we learn to distinguish between "drug-like" and "nondrug-like" molecules?

26 June 2017

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Use of calcium-regulated photoproteins as intracellular Ca2+ indicators

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7 January 2021

Transfected aequorin in the measurement of cytosolic Ca2+ concentration ([Ca2+]c). A critical evaluation.

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7 January 2021

Chemiluminescent and bioluminescent reporter gene assays

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Peptide G protein-coupled receptors meet at Erice

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Endothelin-1 Receptor Binding Assay for High Throughput Chemical Screening

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Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1

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7 January 2021

Reverse physiology: discovery of the novel neuropeptide, orphanin FQ/nociceptin

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A hot spot of binding energy in a hormone-receptor interface

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Signaling routes to CREM and CREB: plasticity in transcriptional activation.

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Drug discovery: a historical perspective

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Firefly luciferase as a tool in molecular and cell biology

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Strategic Pooling of Compounds for High-Throughput Screening

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The quest for novel bioactive peptides utilizing orphan seven-transmembrane-domain receptors

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A novel coumarin-labelled peptide for sensitive continuous assays of the matrix metalloproteinases

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7 January 2021

The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor

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7 January 2021

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

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7 January 2021

Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A

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7 January 2021

A general method for the preparation of internally quenched fluorogenic protease substrates using solid-phase peptide synthesis

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7 January 2021

Identification of a nuclear receptor for bile acids

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7 January 2021

Novel GPCRs and their endogenous ligands: expanding the boundaries of physiology and pharmacology

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Novel fluorogenic substrates for assaying retroviral proteases by resonance energy transfer

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7 January 2021

G16 as a universal G protein adapter: implications for agonist screening strategies.

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7 January 2021

Heterotrimeric G proteins: organizers of transmembrane signals

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7 January 2021

G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C

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7 January 2021

Property distribution of drug-related chemical databases.

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7 January 2021

Homogeneous proximity tyrosine kinase assays: scintillation proximity assay versus homogeneous time-resolved fluorescence.

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7 January 2021

Bile acids: natural ligands for an orphan nuclear receptor

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7 January 2021

Human Genome Project. And the gene number is...?

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7 January 2021

Discovery and preclinical pharmacology of a novel, potent, nonsteroidal estrogen receptor agonist/antagonist, CP-336156, a diaryltetrahydronaphthalene

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7 January 2021

A scoring scheme for discriminating between drugs and nondrugs.

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7 January 2021

Molecular characterization of the melanin-concentrating-hormone receptor

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7 January 2021

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

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7 January 2021

On the size of the active site in proteases. I. Papain

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7 January 2021

Measurement of intracellular calcium using bioluminescent aequorin expressed in human cells

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7 January 2021

Diversity of G proteins in signal transduction

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7 January 2021

A Potent Nonpeptide Antagonist of the Substance P (NK 1 ) Receptor

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7 January 2021

Neurotransmitter receptor binding and drug discovery

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7 January 2021

The Ca-calmodulin-dependent protein kinase cascade

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7 January 2021

A bioluminescent assay for agonist activity at potentially any G-protein-coupled receptor

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7 January 2021

Development of a dual glow-signal firefly and Renilla luciferase assay reagent for the analysis of G-protein coupled receptor signalling

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7 January 2021

Designed molecules that fold to mimic protein secondary structures

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7 January 2021

The role of receptor binding in drug discovery

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7 January 2021

Receptor binding profile suggests multiple mechanisms of action are responsible for ibogaine's putative anti-addictive activity

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7 January 2021

Development and characterization of a whole-cell radioligand binding assay for [125I]gp120 of HIV-1

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7 January 2021

Recognizing molecules with drug-like properties

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7 January 2021

Intramolecularly quenched fluorogenic substrates for hydrolytic enzymes

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7 January 2021

Discovery of a Small Molecule Insulin Mimetic with Antidiabetic Activity in Mice

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7 January 2021

10.1016/S1056-8719(00)00108-8

Identifiers

DOI

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26 June 2017

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