Drugs mediate the transcriptional activation of the 5-aminolevulinic acid synthase (ALAS1) gene via the chicken xenobiotic-sensing nuclear receptor (CXR). (Q30711956)

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English	Drugs mediate the transcriptional activation of the 5-aminolevulinic acid synthase (ALAS1) gene via the chicken xenobiotic-sensing nuclear receptor (CXR).	scientific article

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scholarly article

1 reference

Europe PubMed Central

26 June 2017

Drugs mediate the transcriptional activation of the 5-aminolevulinic acid synthase (ALAS1) gene via the chicken xenobiotic-sensing nuclear receptor (CXR). (English)

1 reference

Europe PubMed Central

26 June 2017

aminolevulinic acid

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based on heuristic

inferred from title

author name string

David J Fraser

1

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Europe PubMed Central

26 June 2017

Michael Podvinec

2

1 reference

Europe PubMed Central

26 June 2017

Michel R Kaufmann

3

1 reference

Europe PubMed Central

26 June 2017

Urs A Meyer

4

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Europe PubMed Central

26 June 2017

language of work or name

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publication date

16 July 2002

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Europe PubMed Central

26 June 2017

Journal of Biological Chemistry

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Europe PubMed Central

26 June 2017

277

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Europe PubMed Central

26 June 2017

34717-34726

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Europe PubMed Central

26 June 2017

38

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Europe PubMed Central

26 June 2017

Limited heme synthesis in porphobilinogen deaminase-deficient mice impairs transcriptional activation of specific cytochrome P450 genes by phenobarbital.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204699200

21 January 2018

Regulation of heme metabolism in rat hepatocytes and hepatocyte cell lines: delta-aminolevulinic acid synthase and heme oxygenase are regulated by different heme-dependent mechanisms

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204699200

21 January 2018

The RXR heterodimers and orphan receptors

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https://api.crossref.org/works/10.1074%2FJBC.M204699200

21 January 2018

Binding of ligands and activation of transcription by nuclear receptors.

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https://api.crossref.org/works/10.1074%2FJBC.M204699200

21 January 2018

CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204699200

21 January 2018

Transcriptional activation of cytochrome P450 CYP2C45 by drugs is mediated by the chicken xenobiotic receptor (CXR) interacting with a phenobarbital response enhancer unit

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204699200

21 January 2018

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204699200

21 January 2018

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204699200

21 January 2018

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204699200

21 January 2018

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204699200

21 January 2018

Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204699200

21 January 2018

Mutational analysis of the CYP2B2 phenobarbital response unit and inhibitory effect of the constitutive androstane receptor on phenobarbital responsiveness

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204699200

21 January 2018

The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204699200

21 January 2018

Reporter constructs with low background activity utilizing the cat gene

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https://api.crossref.org/works/10.1074%2FJBC.M204699200

21 January 2018

Three amino acid substitutions selectively disrupt the activation but not the repression function of the glucocorticoid receptor N terminus.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204699200

21 January 2018

Chicken NFI/TGGCA proteins are encoded by at least three independent genes: NFI-A, NFI-B and NFI-C with homologues in mammalian genomes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204699200

21 January 2018

NUBIScan, an in silico approach for prediction of nuclear receptor response elements

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204699200

21 January 2018

Orphan nuclear receptors: shifting endocrinology into reverse

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204699200

21 January 2018

P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204699200

21 January 2018

Transcriptional regulation of 5-aminolevulinate synthase by phenobarbital and cAMP-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204699200

21 January 2018

Phenobarbital response elements of cytochrome P450 genes and nuclear receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204699200

21 January 2018

MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204699200

21 January 2018

Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204699200

21 January 2018

CCAAT-enhancer-binding proteins (C/EBP) regulate the tissue specific activity of the CD11c integrin gene promoter through functional interactions with Sp1 proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204699200

21 January 2018

Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204699200

21 January 2018

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204699200

21 January 2018

Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204699200

21 January 2018

Porphobilinogen deaminase deficiency in mice causes a neuropathy resembling that of human hepatic porphyria

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204699200

21 January 2018

Chromatin assembly enhances binding to the CYP2B1 phenobarbital-responsive unit (PBRU) of nuclear factor-1, which binds simultaneously with constitutive androstane receptor (CAR)/retinoid X receptor (RXR) and enhances CAR/RXR-mediated activation of

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204699200

21 January 2018

Molecular mechanisms of cytochrome P-450 induction by xenobiotics: An expanded role for nuclear hormone receptors.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204699200

21 January 2018

Induction of 5-aminolevulinate synthase by drugs is independent of increased apocytochrome P450 synthesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204699200

21 January 2018

Identifiers

10.1074/JBC.M204699200

1 reference

Europe PubMed Central

26 June 2017

1 reference

Europe PubMed Central

26 June 2017

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