Neuroimaging, the ischaemic penumbra, and selection of patients for acute stroke therapy (Q30810278)

26 June 2017

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title

Neuroimaging, the ischaemic penumbra, and selection of patients for acute stroke therapy (English)

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26 June 2017

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Geoffrey A Donnan

1

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author name string

Stephen M Davis

series ordinal

2

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26 June 2017

1 November 2002

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26 June 2017

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26 June 2017

1

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26 June 2017

7

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26 June 2017

417-425

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Investigation of patients with stroke and transient ischaemic attacks

26 June 2017

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7 January 2021

Imaging in cerebrovascular disease

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7 January 2021

Thresholds in cerebral ischemia - the ischemic penumbra

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7 January 2021

Tissue plasminogen activator for acute ischemic stroke

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7 January 2021

Lifesaving for stroke

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7 January 2021

Do stroke units save lives?

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7 January 2021

Ischaemic damage of brain microvessels: inherent risks for thrombolytic treatment in stroke

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7 January 2021

Acute stroke: usefulness of early CT findings before thrombolytic therapy.

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7 January 2021

Effect of training in reading CT scans on patient selection for ECASS II

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7 January 2021

CT of acute cerebral ischemia

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7 January 2021

Acute stroke: improved nonenhanced CT detection--benefits of soft-copy interpretation by using variable window width and center level settings

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7 January 2021

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7 January 2021

Hemorrhagic transformation of ischemic brain tissue: asymptomatic or symptomatic?

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7 January 2021

Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS)

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7 January 2021

Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators.

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7 January 2021

Risk factors for severe hemorrhagic transformation in ischemic stroke patients treated with recombinant tissue plasminogen activator: a secondary analysis of the European-Australasian Acute Stroke Study (ECASS II)

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7 January 2021

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7 January 2021

Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy. ASPECTS Study Group. Alberta Stroke Programme Early CT Score

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7 January 2021

Markers of increased risk of intracerebral hemorrhage after intravenous recombinant tissue plasminogen activator therapy for acute ischemic stroke in clinical practice: the Multicenter rt-PA Stroke Survey

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7 January 2021

Agreement and variability in the interpretation of early CT changes in stroke patients qualifying for intravenous rtPA therapy

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7 January 2021

Lack of clinical significance of early ischemic changes on computed tomography in acute stroke.

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7 January 2021

Streptokinase in acute ischemic stroke: an individual patient data meta-analysis : The Thrombolysis in Acute Stroke Pooling Project

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7 January 2021

Identification of major ischemic change. Diffusion-weighted imaging versus computed tomography.

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7 January 2021

Absent middle cerebral artery flow predicts the presence and evolution of the ischemic penumbra.

1 reference

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7 January 2021

Pathophysiological topography of acute ischemia by combined diffusion-weighted and perfusion MRI.

1 reference

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7 January 2021

CT perfusion scanning with deconvolution analysis: pilot study in patients with acute middle cerebral artery stroke

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7 January 2021

A standardized MRI stroke protocol: comparison with CT in hyperacute intracerebral hemorrhage

1 reference

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7 January 2021

Detection of hyperacute parenchymal hemorrhage of the brain using echo-planar T2*-weighted and diffusion-weighted MRI.

1 reference

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7 January 2021

Comparison of CT with diffusion-weighted MRI in patients with hyperacute stroke.

1 reference

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7 January 2021

Significance of early CT signs in acute stroke. A CT scan-diffusion MRI study

1 reference

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7 January 2021

Predictors of hemorrhagic transformation in patients receiving intra-arterial thrombolysis

1 reference

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7 January 2021

Which targets are relevant for therapy of acute ischemic stroke?

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Ischemic penumbra: evidence from functional imaging in man.

1 reference

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7 January 2021

The ischemic penumbra

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https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Use of PET methods for measurement of cerebral energy metabolism and hemodynamics in cerebrovascular disease.

1 reference

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7 January 2021

Mapping the ischaemic penumbra with PET: implications for acute stroke treatment

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Evolving stroke and the ischemic penumbra

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Applications of diffusion-perfusion magnetic resonance imaging in acute ischemic stroke

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Pathobiology of ischaemic stroke: an integrated view

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Multiple molecular penumbras after focal cerebral ischemia

1 reference

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7 January 2021

The ischemic penumbra, injury thresholds, and the therapeutic window for acute stroke

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Identifying hypoxic tissue after acute ischemic stroke using PET and 18F-fluoromisonidazole.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

The fate of hypoxic tissue on18F-fluoromisonidazole positron emission tomography after ischemic stroke

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Neuronal injury in the infarct border: a neuropathological study in the rat.

1 reference

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7 January 2021

Induction of heat shock hsp70 mRNA and HSP70 kDa protein in neurons in the 'penumbra' following focal cerebral ischemia in the rat.

1 reference

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7 January 2021

Purification and characterization of hypoxia-inducible factor 1

1 reference

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7 January 2021

Cortical spreading depression activates trophic factor expression in neurons and astrocytes and protects against subsequent focal brain ischemia.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

SERIAL OBSERVATIONS ON THE PATHOPHYSIOLOGY OF ACUTE STROKE

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7 January 2021

Salvaging the ischaemic penumbra: more than just reperfusion?

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Changes in cerebral tissue perfusion during the first 48 hours of ischaemic stroke: relation to clinical outcome

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Prediction of the final infarct volume within 6 h of stroke using single photon emission computed tomography with technetium-99m hexamethylpropylene amine oxime.

1 reference

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7 January 2021

Prognostic accuracy of cerebral blood flow measurement by perfusion computed tomography, at the time of emergency room admission, in acute stroke patients

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Magnetic resonance imaging of acute stroke

1 reference

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7 January 2021

Diffusion-weighted MRI as an evolving standard of care in acute stroke

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Prediction of stroke outcome with echoplanar perfusion- and diffusion-weighted MRI

1 reference

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7 January 2021

Early detection of regional cerebral ischemia in cats: comparison of diffusion- and T2-weighted MRI and spectroscopy

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Histopathologic correlates of abnormal water diffusion in cerebral ischemia: diffusion-weighted MR imaging and light and electron microscopic study

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Thrombolytic reversal of acute human cerebral ischemic injury shown by diffusion/perfusion magnetic resonance imaging

1 reference

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7 January 2021

Reversible focal ischemic injury demonstrated by diffusion-weighted magnetic resonance imaging in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Resolution of early diffusion-weighted and FLAIR MRI abnormalities in a patient with TIA.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Reversal of early diffusion-weighted magnetic resonance imaging abnormalities does not necessarily reflect tissue salvage in experimental cerebral ischemia.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

MRI of small human stroke shows reversible diffusion changes in subcortical gray matter.

1 reference

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7 January 2021

Severe ADC decreases do not predict irreversible tissue damage in humans

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Diffusion MRI in patients with transient ischemic attacks

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Serial MRI after transient focal cerebral ischemia in rats: dynamics of tissue injury, blood-brain barrier damage, and edema formation

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Temporal evolution of ischemic injury evaluated with diffusion-, perfusion-, and T2-weighted MRI

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Diffusion- and perfusion-weighted MRI response to thrombolysis in stroke

1 reference

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7 January 2021

New imaging strategies for patient selection for thrombolytic and neuroprotective therapies

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

The rationale for new therapies in acute ischaemic stroke

1 reference

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7 January 2021

Penumbral probability thresholds of cortical flumazenil binding and blood flow predicting tissue outcome in patients with cerebral ischaemia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Spontaneous neurological recovery after stroke and the fate of the ischemic penumbra.

1 reference

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7 January 2021

Progressive derangement of periinfarct viable tissue in ischemic stroke.

1 reference

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7 January 2021

Statistical parametric mapping of hypoxic tissue identified by [(18)F]fluoromisonidazole and positron emission tomography following acute ischemic stroke

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Repeat positron emission tomographic studies in transient middle cerebral artery occlusion in cats: residual perfusion and efficacy of postischemic reperfusion.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Dynamic penumbra demonstrated by sequential multitracer PET after middle cerebral artery occlusion in cats

1 reference

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7 January 2021

Limiting neurological damage after stroke: a review of pharmacological treatment options

1 reference

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7 January 2021

Neuroprotection for acute stroke: making clinical trials work

1 reference

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7 January 2021

Which targets are relevant for therapy of acute ischemic stroke?

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Thrombolysis in stroke beyond three hours: Targeting patients with diffusion and perfusion MRI

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Evaluation of early reperfusion and i.v. tPA therapy using diffusion- and perfusion-weighted MRI.

1 reference

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7 January 2021

Monitoring intravenous recombinant tissue plasminogen activator thrombolysis for acute ischemic stroke with diffusion and perfusion MRI

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Diffusion- and perfusion-weighted MRI. The DWI/PWI mismatch region in acute stroke.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Enlargement of human cerebral ischemic lesion volumes measured by diffusion-weighted magnetic resonance imaging.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Diffusion and perfusion MR imaging in acute ischemic stroke: a comparison to SPECT.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Combined diffusion and perfusion MRI with correlation to single-photon emission CT in acute ischemic stroke. Ischemic penumbra predicts infarct growth.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

High spatial resolution 1H-MRSI and segmented MRI of cortical gray matter and subcortical white matter in three regions of the human brain

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Quantitative analysis of short echo time1H-MRSI of cerebral gray and white matter

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Combined (1)H MR spectroscopy and diffusion-weighted MRI improves the prediction of stroke outcome

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Apoptotic cell death: its implications for imaging in the next millennium

1 reference

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7 January 2021

Visualisation of cell death in vivo in patients with acute myocardial infarction

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

99mTc annexin V imaging of neonatal hypoxic brain injury

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

Thalamic microglial activation in ischemic stroke detected in vivo by PET and [11C]PK1195.

1 reference

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7 January 2021

Macrophage and astrocyte populations in relation to [3H]PK 11195 binding in rat cerebral cortex following a local ischaemic lesion.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900189-8

7 January 2021

10.1016/S1474-4422(02)00189-8

Identifiers

DOI

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26 June 2017

1 reference

PubMed ID

12849364