Allosteric drugs: thinking outside the active-site box. (Q30868722)

27 June 2017

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title

Allosteric drugs: thinking outside the active-site box. (English)

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27 June 2017

DeDecker BS

1

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27 June 2017

1 May 2000

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27 June 2017

Chemistry and Biology

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27 June 2017

7

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27 June 2017

5

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27 June 2017

R103-7

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The crystal structure of trp aporepressor at 1.8 A shows how binding tryptophan enhances DNA affinity

27 June 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900115-0

7 January 2021

Allosteric proteins and cellular control systems

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900115-0

7 January 2021

p53 mutations in human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900115-0

7 January 2021

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900115-0

7 January 2021

Mutational studies with the trp repressor of Escherichia coli support the helix-turn-helix model of repressor recognition of operator DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900115-0

7 January 2021

Step-wise mutation of barnase to binase. A procedure for engineering increased stability of proteins and an experimental analysis of the evolution of protein stability

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900115-0

7 January 2021

Additivity of mutational effects in proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900115-0

7 January 2021

Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900115-0

7 January 2021

Mechanism of rescue of common p53 cancer mutations by second-site suppressor mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900115-0

7 January 2021

Pharmacological rescue of mutant p53 conformation and function

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900115-0

7 January 2021

Thermodynamic stability of wild-type and mutant p53 core domain

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900115-0

7 January 2021

Bracing p53 for the war on cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900115-0

7 January 2021

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900115-0

7 January 2021

Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900115-0

7 January 2021

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900115-0

7 January 2021

Small peptides activate the latent sequence-specific DNA binding function of p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900115-0

7 January 2021

Regulation of mutant p53 temperature-sensitive DNA binding.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900115-0

7 January 2021

Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900115-0

7 January 2021

Allosteric effects of DNA on transcriptional regulators

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900115-0

7 January 2021

Protein dynamics from NMR

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900115-0

7 January 2021

10.1016/S1074-5521(00)00115-0

Identifiers

DOI

1 reference

27 June 2017

1 reference

PubMed ID

10801477