DNA polymerase active site is highly mutable: evolutionary consequences (Q30869765)

17 August 2017

DNA polymerase active site is highly mutable: evolutionary consequences (English)

1 reference

17 August 2017

P H Patel

1

1 reference

PMCID

25787

17 August 2017

L A Loeb

series ordinal

2

1 reference

PMCID

25787

17 August 2017

language of work or name

English

0 references

publication date

1 May 2000

1 reference

Proceedings of the National Academy of Sciences of the United States of America

17 August 2017

1 reference

17 August 2017

97

1 reference

17 August 2017

10

1 reference

17 August 2017

5095-5100

1 reference

Calibrating bacterial evolution

17 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25787

Improving enzymes for cancer gene therapy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25787

Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25787

Random sequence mutagenesis and resistance to 5-fluorouridine in human thymidylate synthases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25787

Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25787

Proliferation of mutators in A cell population

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25787

High mutation frequencies among Escherichia coli and Salmonella pathogens.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25787

Random mutagenesis of Thermus aquaticus DNA polymerase I: concordance of immutable sites in vivo with the crystal structure

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25787

Novel human DNA alkyltransferases obtained by random substitution and genetic selection in bacteria

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25787

Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25787

Human immunodeficiency virus reverse transcriptase. Functional mutants obtained by random mutagenesis coupled with genetic selection in Escherichia coli

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25787

Detection and characterization of mammalian DNA polymerase beta mutants by functional complementation in Escherichia coli

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25787

Structure of DNA polymerase I Klenow fragment bound to duplex DNA

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25787

Insights into DNA polymerization mechanisms from structure and function analysis of HIV-1 reverse transcriptase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25787

Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25787

Marked infidelity of human immunodeficiency virus type 1 reverse transcriptase at RNA and DNA template ends

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25787

Rapid purification of recombinant Taq DNA polymerase by freezing and high temperature thawing of bacterial expression cultures

28 July 2018

1 reference

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Estimates of the overall rate of growth of the intestinal microflora of hamsters, guinea pigs, and mice.

28 July 2018

1 reference

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High-copy-number and low-copy-number plasmid vectors for lacZ alpha-complementation and chloramphenicol- or kanamycin-resistance selection

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25787

Evolution in bacteria: evidence for a universal substitution rate in cellular genomes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25787

Mutants generated by the insertion of random oligonucleotides into the active site of the beta-lactamase gene

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25787

Role of mutator alleles in adaptive evolution.

28 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.97.10.5095

Clonal divergence in Escherichia coli as a result of recombination, not mutation.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.97.10.5095

Single-step purification of a thermostable DNA polymerase expressed in Escherichia coli.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25787

Motif A of bacteriophage T4 DNA polymerase: role in primer extension and DNA replication fidelity. Isolation of new antimutator and mutator DNA polymerases.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25787

How E. coli DNA polymerase I (Klenow fragment) distinguishes between deoxy- and dideoxynucleotides

25 November 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.97.10.5095

21 January 2018

Identifiers

DOI

10.1073/PNAS.97.10.5095

1 reference

17 August 2017

0 references

1 reference

17 August 2017

1 reference

PMCID

25787