GSK1614343, a novel ghrelin receptor antagonist, produces an unexpected increase of food intake and body weight in rodents and dogs (Q30968633)

27 June 2017

GSK1614343, a novel ghrelin receptor antagonist, produces an unexpected increase of food intake and body weight in rodents and dogs (English)

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27 June 2017

Vivian J A Costantini

1

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27 June 2017

Elena Vicentini

2

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27 June 2017

Fabio M Sabbatini

3

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27 June 2017

Enzo Valerio

4

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27 June 2017

Stefano Lepore

5

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27 June 2017

Michela Tessari

6

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27 June 2017

Matteo Sartori

7

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27 June 2017

Francesca Michielin

8

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27 June 2017

Sergio Melotto

9

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27 June 2017

Angelo Bifone

10

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27 June 2017

Emilio Merlo Pich

11

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27 June 2017

Mauro Corsi

12

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27 June 2017

22 July 2011

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27 June 2017

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27 June 2017

94

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27 June 2017

2

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27 June 2017

158-168

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Ghrelin induces adiposity in rodents

27 June 2017

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The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion

21 January 2018

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A role for ghrelin in the central regulation of feeding

21 January 2018

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Ghrelin enhances appetite and increases food intake in humans

21 January 2018

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Pharmacokinetics, safety, and endocrine and appetite effects of ghrelin administration in young healthy subjects.

21 January 2018

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Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin

21 January 2018

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Ghrelin: structure and function

21 January 2018

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Ghrelin is a growth-hormone-releasing acylated peptide from stomach

21 January 2018

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Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone

21 January 2018

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Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure

21 January 2018

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Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue

21 January 2018

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Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor

21 January 2018

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Heterogeneity of ghrelin/growth hormone secretagogue receptors. Toward the understanding of the molecular identity of novel ghrelin/GHS receptors.

21 January 2018

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A receptor in pituitary and hypothalamus that functions in growth hormone release

21 January 2018

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Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues

21 January 2018

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Comparative distribution of mRNA encoding the growth hormone secretagogue-receptor (GHS-R) in Microcebus murinus (Primate, lemurian) and rat forebrain and pituitary.

21 January 2018

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The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis.

21 January 2018

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The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity

21 January 2018

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Pharmacological characterization of the ghrelin receptor antagonist, GSK1614343 in rat RC-4B/C cells natively expressing GHS type 1a receptors

21 January 2018

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A novel growth hormone secretagogue-1a receptor antagonist that blocks ghrelin-induced growth hormone secretion but induces increased body weight gain

21 January 2018

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

21 January 2018

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Discovery and pharmacological evaluation of growth hormone secretagogue receptor antagonists

21 January 2018

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Toward potent ghrelin receptor ligands based on trisubstituted 1,2,4-triazole structure. 2. Synthesis and pharmacological in vitro and in vivo evaluations

21 January 2018

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Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity

21 January 2018

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Vaccination against weight gain

21 January 2018

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Lean mean fat reducing "ghrelin" machine: hypothalamic ghrelin and ghrelin receptors as therapeutic targets in obesity

21 January 2018

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On the central mechanism underlying ghrelin's chronic pro-obesity effects in rats: new insights from studies exploiting a potent ghrelin receptor antagonist.

21 January 2018

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Ligand activation domain of human orphan growth hormone (GH) secretagogue receptor (GHS-R) conserved from Pufferfish to humans

21 January 2018

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Orexigenic effects of a growth hormone secretagogue and nitric oxide in aged rats and dogs: correlation with the hypothalamic expression of some neuropeptidergic/receptorial effectors mediating food intake.

21 January 2018

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Biochemical characterization of pituitary-dependent hyperadrenocorticism in the dog

21 January 2018

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Desacyl ghrelin inhibits the orexigenic effect of peripherally injected ghrelin in rats

21 January 2018

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Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor

21 January 2018

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Ghrelin treatment causes increased food intake and retention of lean body mass in a rat model of cancer cachexia.

21 January 2018

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PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake.

21 January 2018

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Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite

21 January 2018

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21 January 2018

Identifiers

DOI

10.1159/000328968

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27 June 2017

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