Toward PKU enzyme replacement therapy: PEGylation with activity retention for three forms of recombinant phenylalanine hydroxylase (Q31037596)

28 June 2017

title

Toward PKU enzyme replacement therapy: PEGylation with activity retention for three forms of recombinant phenylalanine hydroxylase (English)

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enzyme replacement therapy

28 June 2017

main subject

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author name string

Alejandra Gámez

1

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28 June 2017

Lin Wang

2

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28 June 2017

Mary Straub

3

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Marianne G Patch

4

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28 June 2017

Raymond C Stevens

5

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28 June 2017

language of work or name

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1 January 2004

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28 June 2017

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28 June 2017

volume

9

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28 June 2017

issue

1

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28 June 2017

page(s)

124-129

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The structural basis of phenylketonuria

28 June 2017

cites work

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Tetrahydrobiopterin as an alternative treatment for mild phenylketonuria

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2003.11.002

A different approach to treatment of phenylketonuria: phenylalanine degradation with recombinant phenylalanine ammonia lyase

7 January 2021

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Effect of pegylation on pharmaceuticals

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2003.11.002

Use of site-directed mutagenesis to enhance the epitope-shielding effect of covalent modification of proteins with polyethylene glycol

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2003.11.002

Crystal structure of the catalytic domain of human phenylalanine hydroxylase reveals the structural basis for phenylketonuria

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2003.11.002

Structural comparison of bacterial and human iron-dependent phenylalanine hydroxylases: similar fold, different stability and reaction rates

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2003.11.002

Structure/function relationships in human phenylalanine hydroxylase. Effect of terminal deletions on the oligomerization, activation and cooperativity of substrate binding to the enzyme.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2003.11.002

Isolation, characterization, and stability of positional isomers of mono-PEGylated salmon calcitonins

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2003.11.002

N-terminal site-specific mono-PEGylation of epidermal growth factor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2003.11.002

Stabilization of recombinant interferon-alpha by pegylation for encapsulation in PLGA microspheres

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2003.11.002

Expression of recombinant human phenylalanine hydroxylase as fusion protein in Escherichia coli circumvents proteolytic degradation by host cell proteases. Isolation and characterization of the wild-type enzyme

7 January 2021

1 reference

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10.1016/J.YMTHE.2003.11.002

7 January 2021

Identifiers

DOI

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28 June 2017

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