A three-fluorophore FRET assay for high-throughput screening of small-molecule inhibitors of ribosome assembly (Q31062372)

24 September 2017

A three-fluorophore FRET assay for high-throughput screening of small-molecule inhibitors of ribosome assembly (English)

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high-throughput screening

24 September 2017

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author name string

Dagmar Klostermeier

1

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24 September 2017

Pamela Sears

2

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24 September 2017

Chi-Huey Wong

3

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24 September 2017

David P Millar

4

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24 September 2017

James R Williamson

5

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24 September 2017

language of work or name

English

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publication date

17 May 2004

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24 September 2017

Nucleic Acids Research

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24 September 2017

32

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24 September 2017

9

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24 September 2017

2707-2715

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Mg2+-dependent conformational change of RNA studied by fluorescence correlation and FRET on immobilized single molecules.

24 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419595

Generating new ligand-binding RNAs by affinity maturation and disintegration of allosteric ribozymes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419595

Structure of the S15,S6,S18-rRNA complex: assembly of the 30S ribosome central domain

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419595

Design and optimization of effector-activated ribozyme ligases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419595

Modulation of RNA function by aminoglycoside antibiotics

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419595

Aminoglycoside-RNA interactions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419595

Ligand-induced conformational changes observed in single RNA molecules

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419595

Oligonucleotide aptamers that recognize small molecules

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419595

Engineering precision RNA molecular switches

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419595

Isolation and characterization of fluorophore-binding RNA aptamers

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419595

The binding site of a specific aminoglycoside binding RNA molecule

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419595

Specific binding of aminoglycoside antibiotics to RNA.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419595

Recent solution structures of RNA and its complexes with drugs, peptides and proteins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419595

Structure of the A site of Escherichia coli 16S ribosomal RNA complexed with an aminoglycoside antibiotic

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419595

Assembly mapping of 30S ribosomal proteins from E. coli.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419595

Assembly mapping of 30 S ribosomal proteins from Escherichia coli. Further studies.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419595

Antibiotic inhibition of group I ribozyme function

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419595

Altering molecular recognition of RNA aptamers by allosteric selection.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419595

Allosteric selection of ribozymes that respond to the second messengers cGMP and cAMP.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419595

Small molecules that selectively block RNA binding of HIV-1 Rev protein inhibit Rev function and viral production

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419595

Inhibition of the hammerhead ribozyme by neomycin.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419595

Specificity in the binding of aminoglycosides to HIV-RRE RNA

25 November 2018

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12 December 2020

Minimal RNA constructs that specifically bind aminoglycoside antibiotics with high affinities

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12 December 2020

Site-specific labeling of RNA with fluorophores and other structural probes

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12 December 2020

Design of Small Molecules That Recognize RNA: Development of Aminoglycosides as Potential Antitumor Agents That Target Oncogenic RNA Sequences This work was supported by the NIH. We thank Professor Peter Voght for his suggestion of the oncogenic RNA

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12 December 2020

Protein and Mg(2+)-induced conformational changes in the S15 binding site of 16 S ribosomal RNA

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12 December 2020

Identifiers

DOI

10.1093/NAR/GKH588

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24 September 2017

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24 September 2017

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