c-Abl inhibition delays motor neuron degeneration in the G93A mouse, an animal model of amyotrophic lateral sclerosis (Q31104448)

13 August 2017

c-Abl inhibition delays motor neuron degeneration in the G93A mouse, an animal model of amyotrophic lateral sclerosis (English)

1 reference

amyotrophic lateral sclerosis

13 August 2017

0 references

Jun Sone

5

0 references

Hiroaki Adachi

object named as

Hiroaki Adachi

7

0 references

Gen Sobue

10

object named as

Gen Sobue

1 reference

13 August 2017

Ryu Katsumata

1

1 reference

13 August 2017

Shinsuke Ishigaki

2

1 reference

13 August 2017

Masahisa Katsuno

3

1 reference

13 August 2017

Kaori Kawai

4

1 reference

13 August 2017

Zhe Huang

6

1 reference

13 August 2017

Fumiaki Tanaka

8

1 reference

13 August 2017

Fumihiko Urano

9

1 reference

13 August 2017

language of work or name

English

0 references

publication date

25 September 2012

1 reference

13 August 2017

1 reference

13 August 2017

7

1 reference

13 August 2017

9

1 reference

13 August 2017

e46185

1 reference

Creative Commons Attribution 4.0 International

13 August 2017

start time

25 September 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Cooperative roles of c-Abl and Cdk5 in regulation of p53 in response to oxidative stress

21 June 2018

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21 June 2018

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Abl tyrosine kinases regulate cell-cell adhesion through Rho GTPases

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Tyrosine 311 is phosphorylated by c-Abl and promotes the apoptotic effect of PKCdelta in glioma cells

21 June 2018

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ALS: a disease of motor neurons and their nonneuronal neighbors

21 June 2018

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Failure of protein quality control in amyotrophic lateral sclerosis

21 June 2018

1 reference

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Gene expression profile of spinal motor neurons in sporadic amyotrophic lateral sclerosis

21 June 2018

1 reference

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Activation of the neuronal c-Abl tyrosine kinase by amyloid-beta-peptide and reactive oxygen species

21 June 2018

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The crucial role of caspase-9 in the disease progression of a transgenic ALS mouse model

21 June 2018

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Targeting programmed cell death in neurodegenerative diseases

21 June 2018

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The Abl family kinases: mechanisms of regulation and signaling

21 June 2018

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X-Linked inhibitor of apoptosis protein is involved in mutant SOD1-mediated neuronal degeneration

21 June 2018

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Choosing between growth arrest and apoptosis through the retinoblastoma tumour suppressor protein, Abl and p73.

21 June 2018

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Targeting of the c-Abl tyrosine kinase to mitochondria in endoplasmic reticulum stress-induced apoptosis

21 June 2018

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Amyotrophic lateral sclerosis. unfolding the toxicity of the misfolded

21 June 2018

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Regulation of cell death by the Abl tyrosine kinase

21 June 2018

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SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling

21 June 2018

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Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth

21 June 2018

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p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

21 June 2018

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Essential roles for the Abl and Arg tyrosine kinases in neurulation

21 June 2018

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Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

21 June 2018

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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

21 June 2018

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Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

21 June 2018

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A new fused transcript in Philadelphia chromosome positive acute lymphocytic leukaemia

21 June 2018

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Neuroblastoma x spinal cord (NSC) hybrid cell lines resemble developing motor neurons

21 June 2018

1 reference

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Imatinib therapy blocks cerebellar apoptosis and improves neurological symptoms in a mouse model of Niemann-Pick type C disease

21 June 2018

1 reference

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Guidelines for the preclinical in vivo evaluation of pharmacological active drugs for ALS/MND: report on the 142nd ENMC international workshop.

25 November 2018

1 reference

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CHIP overexpression reduces mutant androgen receptor protein and ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model.

25 November 2018

1 reference

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Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: mechanisms of mitochondriopathy and cell death.

25 November 2018

1 reference

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Extramedullary blast crises in CML patients in complete hematological remission treated with imatinib mesylate

25 November 2018

1 reference

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Isolated central nervous system blast crisis in chronic myeloid leukemia

25 November 2018

1 reference

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Extramedullary blast crisis derived from 2 different clones in the central nervous system and neck during complete cytogenetic remission of chronic myelogenous leukemia treated with imatinib mesylate

25 November 2018

1 reference

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Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays.

25 November 2018

1 reference

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Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

25 November 2018

1 reference

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Isolated central nervous system relapse in lymphoid blast crisis chronic myeloid leukemia and acute lymphoblastic leukemia in patients on imatinib therapy

25 November 2018

1 reference

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Molecular signature of late-stage human ALS revealed by expression profiling of postmortem spinal cord gray matter

25 November 2018

1 reference

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Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3458026

Transgenic mice with an expanded CAG repeat controlled by the human AR promoter show polyglutamine nuclear inclusions and neuronal dysfunction without neuronal cell death

25 November 2018

1 reference

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The mouse c-abl locus: molecular cloning and characterization

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3458026

c-Abl has high intrinsic tyrosine kinase activity that is stimulated by mutation of the Src homology 3 domain and by autophosphorylation at two distinct regulatory tyrosines

25 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23049975

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Liposomal cytarabine for treatment of myeloid central nervous system relapse in chronic myeloid leukaemia occurring during imatinib therapy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23049975

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Gene expressions specifically detected in motor neurons (dynactin 1, early growth response 3, acetyl-CoA transporter, death receptor 5, and cyclin C) differentially correlate to pathologic markers in sporadic amyotrophic lateral sclerosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23049975

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0046185

1 reference

13 August 2017

0 references

1 reference

13 August 2017

PubMed publication ID

23049975

1 reference