Sequence plasticity in the antigen-binding site of a therapeutic anti-HER2 antibody (Q31106951)

28 June 2017

Sequence plasticity in the antigen-binding site of a therapeutic anti-HER2 antibody (English)

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28 June 2017

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Resi B Gerstner

1

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28 June 2017

Paul Carter

series ordinal

2

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28 June 2017

Henry B Lowman

series ordinal

3

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28 June 2017

language of work or name

English

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publication date

1 August 2002

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Journal of Molecular Biology

28 June 2017

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28 June 2017

321

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28 June 2017

5

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28 June 2017

851-862

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An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity

28 June 2017

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

Phage display of combinatorial antibody libraries.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

Natural and designer binding sites made by phage display technology

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

Kinetic maturation of an immune response

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

Isolation of picomolar affinity anti-c-erbB-2 single-chain Fv by molecular evolution of the complementarity determining regions in the center of the antibody binding site

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

In vitro evolution of a neutralizing human antibody to human immunodeficiency virus type 1 to enhance affinity and broaden strain cross-reactivity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

Structural plasticity in a remodeled protein-protein interface

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

Stable heterodimers from remodeling the domain interface of a homodimer using a phage display library

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

Plasticity of quaternary structure: twenty-two ways to form a LacI dimer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

Humanization of an anti-p185HER2 antibody for human cancer therapy

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

Trastuzumab: a review of its use in the treatment of metastatic breast cancer overexpressing HER2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

Thermodynamic analysis of an antibody functional epitope

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

Canonical structures for the hypervariable regions of immunoglobulins

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

Conformations of immunoglobulin hypervariable regions

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

Kabat Database and its applications: future directions

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

Total alanine-scanning mutagenesis of insulin-like growth factor I (IGF-I) identifies differential binding epitopes for IGFBP-1 and IGFBP-3.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

Antigen binding thermodynamics and antiproliferative effects of chimeric and humanized anti-p185HER2 antibody Fab fragments

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

Analysis and prediction of the different types of beta-turn in proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

Cation-pi interactions in structural biology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

Aromatic-aromatic interaction: a mechanism of protein structure stabilization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

Additivity of mutational effects in proteins

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

Comprehensive functional maps of the antigen-binding site of an anti-ErbB2 antibody obtained with shotgun scanning mutagenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

Isomerization of an aspartic acid residue in the complementarity-determining regions of a recombinant antibody to human IgE: identification and effect on binding affinity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

Phage display for selection of novel binding peptides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

Selection of phage antibodies by binding affinity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

Rapid mapping of protein functional epitopes by combinatorial alanine scanning

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

High level Escherichia coli expression and production of a bivalent humanized antibody fragment

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

Kinetic analysis of monoclonal antibody-antigen interactions with a new biosensor based analytical system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900677-0

10.1016/S0022-2836(02)00677-0

7 January 2021

Identifiers

DOI

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28 June 2017

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