Modeling promiscuity based on in vitro safety pharmacology profiling data (Q31112194)

28 June 2017

Modeling promiscuity based on in vitro safety pharmacology profiling data (English)

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28 June 2017

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Jeremy L. Jenkins

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Jeremy L Jenkins

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author name string

Kamal Azzaoui

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28 June 2017

Jacques Hamon

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28 June 2017

Bernard Faller

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28 June 2017

Steven Whitebread

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28 June 2017

Edgar Jacoby

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28 June 2017

Laszlo Urban

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28 June 2017

1 June 2007

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28 June 2017

874-880

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Promiscuous drugs compared to selective drugs (promiscuity can be a virtue)

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Keynote review: in vitro safety pharmacology profiling: an essential tool for successful drug development

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QT-interval prolongation by non-cardiac drugs: lessons to be learned from recent experience

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G-protein-coupled receptor affinity prediction based on the use of a profiling dataset: QSAR design, synthesis, and experimental validation

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Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure

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A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

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Prediction of biological targets for compounds using multiple-category Bayesian models trained on chemogenomics databases.

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Global mapping of pharmacological space

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Key aspects of the Novartis compound collection enhancement project for the compilation of a comprehensive chemogenomics drug discovery screening collection

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Are target-family-privileged substructures truly privileged?

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The influence of target family and functional activity on the physicochemical properties of pre-clinical compounds

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Inhibitory effect of carboxylic acid group on hERG binding

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Can the pharmaceutical industry reduce attrition rates?

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Comparison of topological descriptors for similarity-based virtual screening using multiple bioactive reference structures

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The Generation of a Unique Machine Description for Chemical Structures-A Technique Developed at Chemical Abstracts Service

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Identifiers

DOI

10.1002/CMDC.200700036

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28 June 2017

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