Inhibition of Flp recombinase by the topoisomerase I-targeting drugs, camptothecin and NSC-314622. (Q31816410)

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3 November 2019

title

Inhibition of Flp recombinase by the topoisomerase I-targeting drugs, camptothecin and NSC-314622 (English)

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3 November 2019

3

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3 November 2019

Ian Grainge

4

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3 November 2019

Birgitta Ruth Knudsen

7

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author name string

R F Frøhlich

1

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3 November 2019

S G Hansen

2

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3 November 2019

O Westergaard

5

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3 November 2019

M Jayaram

6

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language of work or name

English

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publication date

10 January 2001

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Journal of Biological Chemistry

3 November 2019

published in

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volume

276

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issue

10

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3 November 2019

page(s)

6993-6997

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Phosphoryl transfer in Flp recombination: a template for strand transfer mechanisms

3 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000901200

Eukaryotic DNA topoisomerases I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000901200

Nicking-closing activity associated with bacteriophage lambda int gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000901200

Recombination mediated by vaccinia virus DNA topoisomerase I in Escherichia coli is sequence specific

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000901200

Resolution of Holliday junctions by eukaryotic DNA topoisomerase I

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000901200

Unveiling two distinct ribonuclease activities and a topoisomerase activity in a site-specific DNA recombinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000901200

Structure of Cre recombinase complexed with DNA in a site-specific recombination synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000901200

Conservation of structure and mechanism between eukaryotic topoisomerase I and site-specific recombinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000901200

Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000901200

A model for the mechanism of human topoisomerase I

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000901200

Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000901200

Interaction of an alkylating camptothecin derivative with a DNA base at topoisomerase I-DNA cleavage sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000901200

Mutations in the 2-microns circle site-specific recombinase that abolish recombination without affecting substrate recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000901200

Functional roles of individual recombinase monomers in strand breakage and strand union during site-specific DNA recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000901200

The yeast site-specific recombinase Flp mediates alcoholysis and hydrolysis of the strand cleavage product: mimicking the strand-joining reaction with non-DNA nucleophiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000901200

Camptothecins inhibit the utilization of hydrogen peroxide in the ligation step of topoisomerase I catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000901200

Functional analysis of box I mutations in yeast site-specific recombinases Flp and R: pairwise complementation with recombinase variants lacking the active-site tyrosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000901200

Wild-type Flp recombinase cleaves DNA in trans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000901200

Identification of topoisomerase I mutations affecting both DNA cleavage and interaction with camptothecin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000901200

DNA cleavage in trans by the active site tyrosine during Flp recombination: Switching protein partners before exchanging strands

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000901200

Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000901200

The effect of camptothecin on topoisomerase I catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000901200

Protein-linked DNA strand breaks induced by NSC 314622, a novel noncamptothecin topoisomerase I poison.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000901200

On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000901200

The dihydropyridine dexniguldipine hydrochloride inhibits cleavage and religation reactions of eukaryotic DNA topoisomerase I

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000901200

Effects of mutations in the F361 to R364 region of topoisomerase I (Topo I), in the presence and absence of 9-aminocamptothecin, on the Topo I-DNA interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000901200

Sequence-dependent effect of camptothecin on human topoisomerase I DNA cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000901200

21 January 2018

Identifiers

DOI

10.1074/JBC.C000901200

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11152668%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

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