beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis. (Q31840031)

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English	beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis.	scientific article

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4 July 2017

beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis (English)

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12 May 2020

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C K Combs

1

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12 May 2020

J C Karlo

2

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12 May 2020

S C Kao

3

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12 May 2020

G E Landreth

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12 May 2020

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1 February 2001

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4 July 2017

Journal of Neuroscience

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12 May 2020

21

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12 May 2020

4

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12 May 2020

1179-1188

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12 May 2020

Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease

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https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation and Alzheimer's disease: mechanisms and therapeutic strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor-alpha and phorbol 12-myristate 13-acetate differentially modulate cytotoxic effect of nitric oxide generated by serum deprivation in neuronal PC12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid protein-dependent nitric oxide production from microglial cells and neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology

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https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

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Inflammation and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Widespread peroxynitrite-mediated damage in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti‐inflammatory agents as a therapeutic approach to Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor gamma agonists protect cerebellar granule cells from cytokine-induced apoptotic cell death by inhibition of inducible nitric oxide synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Risk of Alzheimer's disease and duration of NSAID use.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A High Plasma Concentration of TNF- Is Associated With Dementia in Centenarians

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Senile plaques stimulate microglia to release a neurotoxin found in Alzheimer brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonsteroidal anti-inflammatory drugs in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of the p50 subunit of nuclear factor-kappaB increases the vulnerability of hippocampal neurons to excitotoxic injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of superoxide dismutase- and iron-catalyzed nitration of phenolics by peroxynitrite

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of beta-amyloid and prion proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor. Characterization at the molecular, cellular and in vivo level

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comparative immunohistochemical study of Kuru and senile plaques with a special reference to glial reactions at various stages of amyloid plaque formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid converts an acute phase injury response to chronic injury responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxynitrite formation from macrophage-derived nitric oxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

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N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracerebral production of tumor necrosis factor-alpha, a local neuroprotective agent, in Alzheimer disease and vascular dementia

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid-induced IL-1 beta release from an activated human monocyte cell line is calcium- and G-protein-dependent

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Repeated probing of western blots obtained from coomassie brilliant blue-stained or unstained polyacrylamide gels.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytotoxicity of microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-MSH peptides inhibit production of nitric oxide and tumor necrosis factor-alpha by microglial cells activated with beta-amyloid and interferon gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo pharmacological evaluation off two novel type II (inducible) nitric oxide synthase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid induces increased release of interleukin-1 beta from lipopolysaccharide-activated human monocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of Alzheimer beta-amyloid peptide with the human monocytic cell line THP-1 results in a protein kinase C-dependent secretion of tumor necrosis factor-alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptotic, non-apoptotic, and anti-apoptotic pathways of tumor necrosis factor signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor enhancement of transient outward potassium currents in cultured rat cortical neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical trial of indomethacin in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proinflammatory profile of cytokine production by human monocytes and murine microglia stimulated with beta-amyloid[25-35].

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effects of the TNF-ceramide pathway against glutamate neurotoxicity on cultured mesencephalic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxic effects of tumor necrosis factor alpha in primary human neuronal cultures are mediated by activation of the glutamate AMPA receptor subtype: implications for AIDS neuropathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Frequency of stages of Alzheimer-related lesions in different age categories

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid fibrils activate parallel mitogen-activated protein kinase pathways in microglia and THP1 monocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of TNF alpha in adipocyte metabolism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor receptor and Fas signaling mechanisms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TNF-alpha mediates inducible nitric oxide synthase expression in human neuroblastoma cell line by cisplatin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glia increase degeneration of hippocampal neurons through release of tumor necrosis factor-alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In situ immunodetection of neuronal caspase-3 activation in Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of endogenous nitric oxide and peroxynitrite formation in the survival and death of motor neurons in culture.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reciprocal control of inflammatory cytokines, IL-1 and IL-6, and β-amyloid production in cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor-alpha potentiates glutamate neurotoxicity in human fetal brain cell cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of TNF in lymphocyte-mediated cytotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TNF-induced signaling in apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exacerbation of damage and altered NF-kappaB activation in mice lacking tumor necrosis factor receptors after traumatic brain injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropathological indexes of Alzheimer's disease in demented and nondemented persons aged 80 years and older

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatocytes sensitized to tumor necrosis factor-alpha cytotoxicity undergo apoptosis through caspase-dependent and caspase-independent pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RETRACTED: A new mechanism of neurodegeneration: a proinflammatory cytokine inhibits receptor signaling by a survival peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NF-kappaB inactivation converts a hepatocyte cell line TNF-alpha response from proliferation to apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new concept in neurodegeneration: TNFalpha is a silencer of survival signals

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An endogenous 55 kDa TNF receptor mediates cell death in a neural cell line.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal death in cytokine-activated primary human brain cell culture: role of tumor necrosis factor-alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Terminal dUTP nick end labeling (TUNEL) positive cells in the different regions of the brain in normal aging and Alzheimer patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence of neuronal oxidative damage in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of nitric oxide synthase and nitric oxide-mediated apoptosis in neuronal PC12 cells after stimulation with tumor necrosis factor-alpha/lipopolysaccharide

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-amyloid activates the O-2 forming NADPH oxidase in microglia, monocytes, and neutrophils. A possible inflammatory mechanism of neuronal damage in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of tumor necrosis factor alpha action on neurodegeneration: interaction with insulin-like growth factor-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated circulating tumor necrosis factor levels in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor-alpha induces apoptosis in immortalized hypothalamic neurons: involvement of ceramide-generating pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.21-04-01179.2001

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762255&resulttype=core&format=json

12 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762255&resulttype=core&format=json

12 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762255&resulttype=core&format=json

12 May 2020

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