Use of in vitro drug metabolism data to evaluate metabolic drug-drug interactions in man: the need for quantitative databases (Q31900846)

4 July 2017

Use of in vitro drug metabolism data to evaluate metabolic drug-drug interactions in man: the need for quantitative databases (English)

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4 July 2017

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Rodrigues AD

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PubMed ID

11304892

4 July 2017

Winchell GA

series ordinal

2

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PubMed ID

11304892

4 July 2017

Dobrinska MR

series ordinal

3

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4 July 2017

1 April 2001

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The Journal of Clinical Pharmacology

4 July 2017

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4 July 2017

41

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4 July 2017

4

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4 July 2017

368-373

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In vitro assessment of human cytochrome P450.

4 July 2017

1 reference

https://api.crossref.org/works/10.1177%2F00912700122010212

FDA evaluations using in vitro metabolism to predict and interpret in vivo metabolic drug-drug interactions: impact on labeling.

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Assessment of the quality and quantity of drug-drug interaction studies in recent NDA submissions: study design and data analysis issues

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Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions

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Inhibition and induction of human cytochrome P450 (CYP) enzymes

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In vitro approaches to predicting drug interactions in vivo.

21 January 2018

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Quantitative drug interactions prediction system (Q-DIPS): a computer-based prediction and management support system for drug metabolism interactions.

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Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction

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First-pass metabolism of midazolam by the human intestine.

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Extensive impairment of triazolam and alprazolam clearance by short-term low-dose ritonavir: the clinical dilemma of concurrent inhibition and induction.

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Pharmacokinetics of the newer benzodiazepines

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Clinical pharmacokinetics and pharmacodynamics of zolpidem. Therapeutic implications

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Triazolam disposition

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Zolpidem. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential

21 January 2018

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Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole.

21 January 2018

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Zolpidem metabolism in vitro: responsible cytochromes, chemical inhibitors, and in vivo correlations

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Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily.

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Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in transplant patients: are the statins mechanistically similar?

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Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions

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Human P450 metabolism of warfarin

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Oral triazolam is potentially hazardous to patients receiving systemic antimycotics ketoconazole or itraconazole

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What are narrow therapeutic index drugs?

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Use of in vitro human metabolism studies in drug development. An industrial perspective

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An evaluation of the integration of pharmacokinetic and pharmacodynamic principles in clinical drug development. Experience within Hoffmann La Roche

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In vitro metabolic interaction studies: experience of the Food and Drug Administration

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Preclinical and in vitro assessment of the potential of D0870, an antifungal agent, for producing clinical drug interactions

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Kinetic and dynamic interaction study of zolpidem with ketoconazole, itraconazole, and fluconazole

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Ketoconazole inhibition of triazolam and alprazolam clearance: differential kinetic and dynamic consequences

21 January 2018

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Effect of itraconazole on the single oral dose pharmacokinetics and pharmacodynamics of alprazolam

21 January 2018

1 reference

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Biotransformation of alprazolam by members of the human cytochrome P4503A subfamily

21 January 2018

1 reference

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10.1177/00912700122010212

21 January 2018

Identifiers

DOI

1 reference

4 July 2017

1 reference

PubMed ID

11304892