BCL-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis (Q31915818)

5 July 2017

BCL-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis (English)

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5 July 2017

Jans DA

1

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5 July 2017

Sutton VR

2

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5 July 2017

Jans P

3

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5 July 2017

Froelich CJ

4

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5 July 2017

Trapani JA

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5 July 2017

language of work or name

English

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publication date

1 February 1999

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Journal of Biological Chemistry

5 July 2017

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5 July 2017

274

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5 July 2017

7

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5 July 2017

3953-3961

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Cytolytic activity of purified cytoplasmic granules from cytotoxic rat large granular lymphocyte tumors

5 July 2017

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https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Internal Disintegration Model of Cytotoxic Lymphocyte-Induced Target Damage

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Granzyme A is an interleukin 1 beta-converting enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Granzyme A released upon stimulation of cytotoxic T lymphocytes activates the thrombin receptor on neuronal cells and astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Induction of target cell DNA release by the cytotoxic T lymphocyte granule protease granzyme A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

In vitro- and ex vivo-derived cytolytic leukocytes from granzyme A x B double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Possible involvement of CTL granule proteases in target cell DNA breakdown

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Nuclear transport of granzyme B (fragmentin-2). Dependence of perforin in vivo and cytosolic factors in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Interleukin-1 beta-converting enzyme-like protease cleaves DNA-dependent protein kinase in cytotoxic T cell killing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Bcl-2 prevents death of factor-deprived cells but fails to prevent apoptosis in targets of cell mediated killing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Localization of granzyme B in the nucleus. A putative role in the mechanism of cytotoxic lymphocyte-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Immunopurification of functional Asp-ase (natural killer cell granzyme B) using a monoclonal antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Human perforin: rapid enrichment by immobilized metal affinity chromatography (IMAC) for whole cell cytotoxicity assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Calculation of protein extinction coefficients from amino acid sequence data

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

A consensus cAMP-dependent protein kinase (PK-A) site in place of the CcN motif casein kinase II site simian virus 40 large T-antigen confers PK-A-mediated regulation of nuclear import

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Interaction and regulation of subcellular localization of CED-4 by CED-9

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

The target cell nucleus is not required for cell-mediated granzyme- or Fas-based cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Depletion of calcium from the lumen of endoplasmic reticulum reversibly inhibits passive diffusion and signal-mediated transport into the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Conformational states of the nuclear pore complex induced by depletion of nuclear Ca2+ stores.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Activation of cyclin A-dependent protein kinases during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Efficient Nuclear Targeting of Granzyme B and the Nuclear Consequences of Apoptosis Induced by Granzyme B and Perforin Are Caspase-dependent, but Cell Death Is Caspase-independent

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Granzyme B/Perforin-Mediated Apoptosis of Jurkat Cells Results in Cleavage of Poly(ADP-ribose) Polymerase to the 89-kDa Apoptotic Fragment and Less Abundant 64-kDa Fragment

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Regulation of Fas(Apo-1/CD95)- and perforin-mediated lytic pathways of primary cytotoxic T lymphocytes by the protooncogene bcl-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Bcl–2 protects from lethal hepatic apoptosis induced by an ant–Fas antibody in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Rapid purification of cationic granule proteases: application to human granzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Target cell lysis by CTL granule exocytosis is independent of ICE/Ced-3 family proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

Ultrastructural localization of bcl-2 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.7.3953

21 January 2018

Identifiers

DOI

10.1074/JBC.274.7.3953

1 reference

release_yrkjfwcjyvh5vcaausvaqssq7i

5 July 2017

1 reference

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24 November 2022

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