History of the development of new vitamin D analogs: studies on 22-oxacalcitriol (OCT) and 2beta-(3-hydroxypropoxy)calcitriol (ED-71). (Q31943055)

5 July 2017

History of the development of new vitamin D analogs: studies on 22-oxacalcitriol (OCT) and 2beta-(3-hydroxypropoxy)calcitriol (ED-71). (English)

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5 July 2017

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Y Nishii

1

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PubMed ID

11179721

5 July 2017

T Okano

series ordinal

2

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5 July 2017

1 March 2001

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5 July 2017

66

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3-5

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5 July 2017

137-146

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Isolation and identification of 1,25-dihydroxycholecalciferol. A metabolite of vitamin D active in intestine

5 July 2017

1 reference

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7 January 2021

Identification of 1,25-Dihydroxycholecalciferol, a New Kidney Hormone controlling Calcium Metabolism

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7 January 2021

1,25-dihydroxycholecalciferol: identification of the proposed active form of vitamin D3 in the intestine

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7 January 2021

lα,25-dihydroxyvitamin D3 receptor: competitive binding of vitamin D analogs

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7 January 2021

Intestinal cytosol binders of 1,25-dihydroxyvitamin D and 25-hydroxyvitamin D

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7 January 2021

Target cells for 1,25-dihydroxyvitamin D3 in intestinal tract, stomach, kidney, skin, pituitary, and parathyroid

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7 January 2021

Biochemical evidence for 1,25-dihydroxyvitamin D receptor macromolecules in parathyroid, pancreatic, pituitary, and placental tissues

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7 January 2021

Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3

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7 January 2021

Synthetic studies of vitamin D3 analogues. VIII. Synthesis of 22-oxavitamin D3 analogues

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7 January 2021

24-homologated 1,25-dihydroxyvitamin D3 compounds: separation of calcium and cell differentiation activities

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7 January 2021

1,25-Dihydroxy-16-ene-23-yne-vitamin D3 prolongs survival time of leukemic mice

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7 January 2021

Synthetic analogues of vitamin D3 with an oxygen atom in the side chain skeleton. A trial of the development of vitamin D compounds which exhibit potent differentiation-inducing activity without inducing hypercalcemia

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7 January 2021

Effects of a novel vitamin D analogue MC903 on cell proliferation and differentiation in vitro and on calcium metabolism in vivo

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7 January 2021

Regulatory activities of 2 beta-(3-hydroxypropoxy)-1 alpha, 25-dihydroxyvitamin D3, a novel synthetic vitamin D3 derivative, on calcium metabolism

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7 January 2021

20-EPI-vitamin D3 analogues: A novel class of potent regulators of cell growth and immune responses

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7 January 2021

Differential activities of 1alpha,25-dihydroxy-16-ene-vitamin D(3) analogs and their 3-epimers on human promyelocytic leukemia (HL-60) cell differentiation and apoptosis

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7 January 2021

Synthesis and biological activity of 1 alpha, 25-dihydroxy-18-norvitamin D3 and 1 alpha, 25-dihydroxy-18,19-dinorvitamin D3

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7 January 2021

Singly dehydroxylated A-ring analogues of 19-nor-1alpha,25-dihydroxyvitamin D3 and 19-nor-22-oxa-1alpha,25-dihydroxyvitamin D3: novel vitamin D3 analogues with potent transcriptional activity but extremely low affinity for vitamin D receptor

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7 January 2021

The binding properties, with blood proteins, and tissue distribution of 22-oxa-1 alpha,25-dihydroxyvitamin D3, a noncalcemic analogue of 1 alpha, 25-dihydroxyvitamin D3, in rats

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7 January 2021

Protein-binding properties of 22-oxa-1 alpha,25-dihydroxyvitamin D3, a synthetic analogue of 1 alpha,25-dihydroxyvitamin D3

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7 January 2021

Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein

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7 January 2021

Binding of vitamin D to low-density-lipoprotein (LDL) and LDL receptor-mediated pathway into cells

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7 January 2021

An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3

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7 January 2021

Selective interaction of vitamin D receptor with transcriptional coactivators by a vitamin D analog

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7 January 2021

The noncalcemic analogue of vitamin D, 22-oxacalcitriol, suppresses parathyroid hormone synthesis and secretion

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7 January 2021

Suppression of PTH and decreased action on bone are partially responsible for the low calcemic activity of 22-oxacalcitriol relative to 1,25-(OH)2D3

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7 January 2021

Differential effects of 1,25-(OH)2D3 and 22-oxacalcitriol on phosphate and calcium metabolism

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7 January 2021

1,25-dihydroxyvitamin D3 and 22-oxacalcitriol prevent the decrease in vitamin D receptor content in the parathyroid glands of uremic rats

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7 January 2021

On the mechanisms for the selective action of vitamin D analogs

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7 January 2021

Distinct conformational changes induced by 20-epi analogues of 1 alpha,25-dihydroxyvitamin D3 are associated with enhanced activation of the vitamin D receptor

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7 January 2021

Conformationally Restricted Analogs of 1α,25-Dihydroxyvitamin D3and Its 20-Epimer: Compounds for Study of the Three-Dimensional Structure of Vitamin D Responsible for Binding to the Receptor

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7 January 2021

Conformation−Function Relationship of Vitamin D: Conformational Analysis Predicts Potential Side-Chain Structure

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7 January 2021

Three-dimensional structure-function relationship of vitamin D: Side chain location and various activities

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7 January 2021

The effect of 1 alpha-hydroxyvitamin D3 on primary antibody formation in mice

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7 January 2021

A synthetic analogue of vitamin D3, 22-oxa-1 alpha,25-dihydroxyvitamin D3, is a potent modulator of in vivo immunoregulating activity without inducing hypercalcemia in mice

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7 January 2021

Prevention of immunological disorders in MRL/l mice by a new synthetic analogue of vitamin D3: 22-oxa-1 alpha,25-dihydroxyvitamin D3

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7 January 2021

Catalytic asymmetric syntheses and biological activities of singly dehydroxylated 19-nor-1alpha,25-dihydroxyvitamin D(3) A-ring analogs in cancer cell differentiation and apoptosis

1 reference

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7 January 2021

Novel ring A stereoisomers of 2-methyl-1alpha,25-dihydroxyvitamin D(3) and 2-methyl-20-epi-1alpha,25-dihydroxyvitamin D(3): transactivation of target genes and modulation of differentiation in human promyelocytic leukemia (HL-60) cells

1 reference

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7 January 2021

10.1016/S0039-128X(00)00227-0

Identifiers

DOI

1 reference

5 July 2017

1 reference

PubMed ID

11179721