New scaffolds in the development of mu opioid-receptor ligands (Q33186736)

23 July 2017

title

New scaffolds in the development of mu opioid-receptor ligands (English)

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23 July 2017

Daniel Pagé

1

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23 July 2017

Natalie Nguyen

2

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23 July 2017

Sylvain Bernard

3

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23 July 2017

Martin Coupal

4

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23 July 2017

Mylène Gosselin

5

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23 July 2017

Julie Lepage

6

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23 July 2017

Lynda Adam

7

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23 July 2017

William Brown

8

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23 July 2017

language of work or name

English

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publication date

1 May 2003

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Bioorganic & Medicinal Chemistry Letters

23 July 2017

published in

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23 July 2017

volume

13

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23 July 2017

issue

9

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23 July 2017

page(s)

1585-1589

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Non-peptide opioid receptor ligands - recent advances. Part I - agonists

23 July 2017

cites work

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Cocaine place preference is blocked by the delta-opioid receptor antagonist, naltrindole

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The TIPP opioid peptide family: development of delta antagonists, delta agonists, and mixed mu agonist/delta antagonists

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Evolution of the Dmt-Tic pharmacophore: N-terminal methylated derivatives with extraordinary delta opioid antagonist activity

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Novel Dmt-Tic dipeptide analogues as selective delta-opioid receptor antagonists

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Assessment of substitution in the second pharmacophore of Dmt-Tic analogues

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7 January 2021

Opioid pseudopeptides containing heteroaromatic or heteroaliphatic nuclei

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7 January 2021

Further studies on the Dmt-Tic pharmacophore: hydrophobic substituents at the C-terminus endow delta antagonists to manifest mu agonism or mu antagonism.

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Novel C-terminus modifications of the Dmt-Tic motif: a new class of dipeptide analogues showing altered pharmacological profiles toward the opioid receptors

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Evaluation of the Dmt-Tic pharmacophore: conversion of a potent delta-opioid receptor antagonist into a potent delta agonist and ligands with mixed properties

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Potent delta-opioid receptor agonists containing the Dmt-Tic pharmacophore

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Probing the shape of a hydrophobic pocket in the active site of delta-opioid antagonists.

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Stereospecific synthesis of (2S)-2-methyl-3-(2',6'-dimethyl-4'-hydroxyphenyl)-propionic acid (Mdp) and its incorporation into an opioid peptide

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[2',6'-Dimethyltyrosine]dynorphin A(1-11)-NH2 analogues lacking an N-terminal amino group: potent and selective kappa opioid antagonists

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A facile synthesis of chiral N-protected β-amino alcohols

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10.1016/S0960-894X(03)00194-X

Identifiers

DOI

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23 July 2017

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