Grb2 SH2 domain-binding peptide analogs as potential anticancer agents (Q33187148)

23 July 2017

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title

Grb2 SH2 domain-binding peptide analogs as potential anticancer agents (English)

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23 July 2017

Feng-Di T Lung

1

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23 July 2017

Jya-Yin Tsai

series ordinal

2

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23 July 2017

publication date

1 January 2003

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23 July 2017

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23 July 2017

volume

71

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23 July 2017

issue

2

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23 July 2017

page(s)

132-140

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Trying on a new pair of SH2s

23 July 2017

cites work

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Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation

21 January 2018

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Protein modules and signalling networks

21 January 2018

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Signaling through scaffold, anchoring, and adaptor proteins

21 January 2018

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Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors

21 January 2018

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SH2 domains recognize specific phosphopeptide sequences

21 January 2018

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Multiple Grb2-protein complexes in human cancer cells

21 January 2018

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Oncogenes and signal transduction

21 January 2018

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New intracellular targets for therapeutic drug design

21 January 2018

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SH2 domain protein interaction and possibilities for pharmacological intervention

21 January 2018

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Targeting signal transduction in the discovery of antiproliferative drugs

21 January 2018

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The GRB2/Sem-5 adaptor protein

21 January 2018

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The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

21 January 2018

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Receptor protein-tyrosine kinases and their signal transduction pathways

21 January 2018

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Controlling epidermal growth factor (EGF)-stimulated Ras activation in intact cells by a cell-permeable peptide mimicking phosphorylated EGF receptor

21 January 2018

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Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries

21 January 2018

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Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

21 January 2018

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SH2 and SH3 domains: potential targets for anti-cancer drug design

21 January 2018

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Recognition and specificity in protein tyrosine kinase-mediated signalling

21 January 2018

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Crystal structure of the mammalian Grb2 adaptor

21 January 2018

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Structural basis for specificity of Grb2-SH2 revealed by a novel ligand binding mode

21 January 2018

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Structural and conformational requirements for high-affinity binding to the SH2 domain of Grb2(1)

21 January 2018

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Structure-based design, synthesis, and X-ray crystallography of a high-affinity antagonist of the Grb2-SH2 domain containing an asparagine mimetic

21 January 2018

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Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor

21 January 2018

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Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation

21 January 2018

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Dual specificity of Src homology 2 domains for phosphotyrosine peptide ligands

21 January 2018

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Folding study of an Aib-rich peptide in DMSO by molecular dynamics simulations

21 January 2018

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Novel peptide inhibitors for Grb2 SH2 domain and their detection by surface plasmon resonance

21 January 2018

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Inhibitors of Ras signal transduction as antitumor agents

21 January 2018

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Inhibition of SH2 domain/phosphoprotein association by a nonhydrolyzable phosphonopeptide

21 January 2018

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Nonhydrolyzable phosphotyrosyl mimetics for the preparation of phosphatase-resistant SH2 domain inhibitors.

21 January 2018

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N-terminal carboxyl and tetrazole-containing amides as adjuvants to Grb2 SH2 domain ligand binding

21 January 2018

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Rapid identification of phosphopeptide ligands for SH2 domains. Screening of peptide libraries by fluorescence-activated bead sorting

21 January 2018

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Peptides on phage: a vast library of peptides for identifying ligands

21 January 2018

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Identification of phosphopeptide ligands for the Src-homology 2 (SH2) domain of Grb2 by phage display

21 January 2018

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Potent inhibitory ligands of the GRB2 SH2 domain from recombinant peptide libraries

21 January 2018

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Functional preference of the constituent amino acid residues in a phage-library-based nonphosphorylated inhibitor of the Grb2-SH2 domain

21 January 2018

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Significant compensatory role of position Y-2 conferring high affinity to non-phosphorylated inhibitors of Grb2-SH2 domain

21 January 2018

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Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model

21 January 2018

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The Role of 4-phosphonodifluoromethyl- and 4-phosphono-phenylalanine in the selectivity and cellular uptake of SH2 domain ligands

21 January 2018

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Modular binding domains in signal transduction proteins

21 January 2018

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Pharmaceutical research in molecular oncology

21 January 2018

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Signal-transduction therapy. A novel approach to disease management

21 January 2018

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Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

21 January 2018

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Highly potent inhibitors of the Grb2-SH2 domain

21 January 2018

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Potent dipeptide inhibitors of the pp60c-src SH2 domain

21 January 2018

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Discovery of 3-aminobenzyloxycarbonyl as an N-terminal group conferring high affinity to the minimal phosphopeptide sequence recognized by the Grb2-SH2 domain

21 January 2018

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Structure-based design and synthesis of high affinity tripeptide ligands of the Grb2-SH2 domain

21 January 2018

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Potent antagonists of the SH2 domain of Grb2: optimization of the X+1 position of 3-amino-Z-Tyr(PO3H2)-X+1-Asn-NH2

21 January 2018

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Mapping the X(+1) binding site of the Grb2-SH2 domain with alpha,alpha-disubstituted cyclic alpha-amino acids

21 January 2018

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Differential utilization of ShcA tyrosine residues and functional domains in the transduction of epidermal growth factor-induced mitogen-activated protein kinase activation in 293T cells and nerve growth factor-induced neurite outgrowth in PC12 cell

21 January 2018

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Small peptides containing phosphotyrosine and adjacent alphaMe-phosphotyrosine or its mimetics as highly potent inhibitors of Grb2 SH2 domain

21 January 2018

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4'-O-[2-(2-fluoromalonyl)]-L-tyrosine: a phosphotyrosyl mimic for the preparation of signal transduction inhibitory peptides

21 January 2018

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Potent inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands

21 January 2018

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Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

21 January 2018

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Nonphosphorylated peptide ligands for the Grb2 Src homology 2 domain

21 January 2018

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Structural requirements for Tyr in the consensus sequence Y-E-N of a novel nonphosphorylated inhibitor to the Grb2-SH2 domain

21 January 2018

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Solution structure and dynamics of G1TE, a nonphosphorylated cyclic peptide inhibitor for the Grb2 SH2 domain

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BIP.10396

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23 July 2017

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