Expression of functional Schistosoma mansoni Smad4: role in Erk-mediated transforming growth factor beta (TGF-beta) down-regulation (Q33195224)

23 July 2017

Expression of functional Schistosoma mansoni Smad4: role in Erk-mediated transforming growth factor beta (TGF-beta) down-regulation (English)

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23 July 2017

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5 February 2019

14-3-3 protein epsilon

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3

Philip T LoVerde

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23 July 2017

Ahmed Osman

1

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PubMed ID

14630909

23 July 2017

Edward G Niles

series ordinal

2

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PubMed ID

14630909

23 July 2017

language of work or name

English

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publication date

20 November 2003

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Journal of Biological Chemistry

23 July 2017

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23 July 2017

279

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23 July 2017

8

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23 July 2017

6474-6486

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Developmental plasticity in schistosomes and other helminths

23 July 2017

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https://api.crossref.org/works/10.1074%2FJBC.M310949200

Molecular crosstalk in host-parasite relationships: schistosome- and leech-host interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Presidential address. Sex and schistosomes: an interesting biological interplay with control implications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

The Schistosoma mansoni epidermal growth factor receptor homologue, SER, has tyrosine kinase activity and is localized in adult muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

A divergent member of the transforming growth factor beta receptor family from Schistosoma mansoni is expressed on the parasite surface membrane.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Characterization of the Ras homologue of Schistosoma mansoni.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Functional conservation of Schistosoma mansoni Smads in TGF-beta signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Identification and characterization of a Smad2 homologue from Schistosoma mansoni, a transforming growth factor-beta signal transducer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

An unusual receptor tyrosine kinase of Schistosoma mansoni contains a Venus Flytrap module.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Physiological actions and clinical applications of transforming growth factor-beta (TGF-beta).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Bone morphogenetic proteins in development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Mechanism of activation of the TGF-beta receptor

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M310949200

MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamily.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

A human Mad protein acting as a BMP-regulated transcriptional activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Receptor-associated Mad homologues synergize as effectors of the TGF-beta response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Transcriptional control by the TGF-beta/Smad signaling system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Human Smad3 and Smad4 are sequence-specific transcription activators

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Characterization of functional domains within Smad4/DPC4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

A distinct nuclear localization signal in the N terminus of Smad 3 determines its ligand-induced nuclear translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Importin beta mediates nuclear translocation of Smad 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-beta receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Smad1 recognition and activation by the ALK1 group of transforming growth factor-beta family receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Determinants of specificity in TGF-beta signal transduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Transcriptional regulation by extracellular signals: mechanisms and specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Crystal structure of a transcriptionally active Smad4 fragment

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

A cDNA encoding an alpha-tubulin from Schistosoma mansoni

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Type 1 plasminogen activator inhibitor gene: functional analysis and glucocorticoid regulation of its promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Transforming growth factor-beta (TGF-beta)-induced down-regulation of cyclin A expression requires a functional TGF-beta receptor complex. Characterization of chimeric and truncated type I and type II receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Transcriptome analysis of the acoelomate human parasite Schistosoma mansoni

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

An extended bipartite nuclear localization signal in Smad4 is required for its nuclear import and transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

In or out? The dynamics of Smad nucleocytoplasmic shuttling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

The taxonomy of developmental control in Caenorhabditis elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Human transforming growth factor-beta activates a receptor serine/threonine kinase from the intravascular parasite Schistosoma mansoni

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Oncogenic ras represses transforming growth factor-beta /Smad signaling by degrading tumor suppressor Smad4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Interplay of signal mediators of decapentaplegic (Dpp): molecular characterization of mothers against dpp, Medea, and daughters against dpp.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

Identification of Ras, MAP kinases, and a GAP protein in Schistosoma mansoni by immunoblotting and their putative involvement in male-female interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310949200

21 January 2018

Identifiers

DOI

10.1074/JBC.M310949200

1 reference

23 July 2017

1 reference

PubMed ID

14630909