Development of small molecules that mimic the binding of omega-conotoxins at the N-type voltage-gated calcium channel (Q33204014)

23 July 2017

Development of small molecules that mimic the binding of omega-conotoxins at the N-type voltage-gated calcium channel (English)

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23 July 2017

Christina I. Schroeder

object named as

Christina I Schroeder

series ordinal

1

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Mark L. Smythe

object named as

Mark L Smythe

series ordinal

2

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Richard J. Lewis

object named as

Richard J Lewis

series ordinal

3

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publication date

1 January 2004

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23 July 2017

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23 July 2017

8

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23 July 2017

2

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23 July 2017

127-134

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https://scigraph.springernature.com/pub.10.1023/b:modi.0000025656.79632.86

23 July 2017

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cites work

Synthesis and structure-activity relationship of substituted 1,2,3,4-tetrahydroisoquinolines as N-type calcium channel blockers

1 reference

12 December 2020

Diversity of Conus neuropeptides

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12 December 2020

Models of ion pores in N-type voltage-gated calcium channels

1 reference

12 December 2020

Structure-function relationships of omega-conotoxin GVIA. Synthesis, structure, calcium channel binding, and functional assay of alanine-substituted analogues.

1 reference

12 December 2020

Calcium channel subtypes in rat brain: biochemical characterization of the high-affinity receptors for omega-conopeptides SNX-230 (synthetic MVIIC), SNX-183 (SVIB), and SNX-111 (MVIIA).

1 reference

12 December 2020

Structural determinants of the blockade of N-type calcium channels by a peptide neurotoxin

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12 December 2020

Inhibition of calcium channels in rat central and peripheral neurons by omega-conotoxin MVIIC

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12 December 2020

Roles of key functional groups in omega-conotoxin GVIA synthesis, structure and functional assay of selected peptide analogues

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12 December 2020

Omega-conotoxin GVIA binding to a high-affinity receptor in brain: characterization, calcium sensitivity, and solubilization

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12 December 2020

Effect of cilnidipine, a novel dihydropyridine Ca++-channel antagonist, on N-type Ca++ channel in rat dorsal root ganglion neurons

1 reference

12 December 2020

The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices

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12 December 2020

Three-dimensional structure in solution of the calcium channel blocker omega-conotoxin

1 reference

12 December 2020

Solution structure of the calcium channel antagonist omega-conotoxin GVIA

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12 December 2020

Residue Gly1326 of the N-type calcium channel alpha 1B subunit controls reversibility of omega-conotoxin GVIA and MVIIA block

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12 December 2020

Solution structure of omega-conotoxin MVIIA using 2D NMR spectroscopy.

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12 December 2020

C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity

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12 December 2020

Structural and dynamic characterization of omega-conotoxin MVIIA: the binding loop exhibits slow conformational exchange

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12 December 2020

Structure-activity study and analgesic efficacy of amino acid derivatives as N-type calcium channel blockers

1 reference

12 December 2020

Adverse effects associated with the intrathecal administration of ziconotide

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12 December 2020

Structure-activity relationships of omega-conotoxins at N-type voltage-sensitive calcium channels

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12 December 2020

Structure-activity study of L-cysteine-based N-type calcium channel blockers: optimization of N- and C-terminal substituents

1 reference

12 December 2020

Calcium channel diversity and neurotransmitter release: the omega-conotoxins and omega-agatoxins

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12 December 2020

(S)-4-Methyl-2-(methylamino)pentanoic acid [4, 4-bis(4-fluorophenyl)butyl]amide hydrochloride, a novel calcium channel antagonist, is efficacious in several animal models of pain

1 reference

12 December 2020

Antagonists of neuronal calcium channels: structure, function, and therapeutic implications

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12 December 2020

Selective N-type calcium channel antagonist omega conotoxin MVIIA is neuroprotective against hypoxic neurodegeneration in organotypic hippocampal-slice cultures.

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12 December 2020

Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphenylglycoluril

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12 December 2020

Tyr13 is essential for the activity of omega-conotoxin MVIIA and GVIA, specific N-type calcium channel blockers

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12 December 2020

Blockade of N-type Ca2+ current by cilnidipine (FRC-8653) in acutely dissociated rat sympathetic neurones.

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12 December 2020

Refined solution structure of omega-conotoxin GVIA: implications for calcium channel binding

1 reference

12 December 2020

Solution structure of omega-conotoxin GVIA using 2-D NMR spectroscopy and relaxation matrix analysis

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12 December 2020

The cyclic contryphan motif CPxXPXC, a robust scaffold potentially useful as an omega-conotoxin mimic

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12 December 2020

The cystine knot structure of ion channel toxins and related polypeptides

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12 December 2020

A molecular mechanism for toxin block in N-type calcium channels.

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12 December 2020

A consensus structure for omega-conotoxins with different selectivities for voltage-sensitive calcium channel subtypes: comparison of MVIIA, SVIB and SNX-202

1 reference

12 December 2020

Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes

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12 December 2020

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12 December 2020

Omega-conotoxin GVIA and dihydropyridines discriminate two types of Ca2+ channels involved in GABA release from striatal neurons in culture.

1 reference

12 December 2020

L-Cysteine based N-type calcium channel blockers: structure-activity relationships of the C-terminal lipophilic moiety, and oral analgesic efficacy in rat pain models

1 reference

12 December 2020

Calcium channel antagonists. Omega-conotoxin defines a new high affinity site.

1 reference

12 December 2020

The calcium channel antagonist, ω-conotoxin, and electric organ nerve terminals: binding and inhibition of transmitter release and calcium influx

1 reference

12 December 2020

Structure-activity analysis of a Conus peptide blocker of N-type neuronal calcium channels

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12 December 2020

Three-Dimensional Structure of ω-Conotoxin GVIA Determined by 1 H-NMR

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12 December 2020

Exploring privileged structures: the combinatorial synthesis of cyclic peptides

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12 December 2020

Design and synthesis of type-III mimetics of omega-conotoxin GVIA

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12 December 2020

Selective blockade of N-type calcium channels by levetiracetam

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12 December 2020

Flunarizine blocks elevation of free cytosolic calcium in synaptosomes following sustained depolarization

1 reference

12 December 2020

Hydroxyl group of Tyr13 is essential for the activity of omega-conotoxin GVIA, a peptide toxin for N-type calcium channel

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12 December 2020

Cardiovascular and autonomic effects of omega-conotoxins MVIIA and CVID in conscious rabbits and isolated tissue assays

1 reference

12 December 2020

FOUNDATION: a program to retrieve all possible structures containing a user-defined minimum number of matching query elements from three-dimensional databases

1 reference

12 December 2020

Design and biological evaluation of non-peptide analogues of omega-conotoxin MVIIA

1 reference

12 December 2020

Fluspirilene block of N-type calcium current in NGF-differentiated PC12 cells

1 reference

12 December 2020

10.1023/B:MODI.0000025656.79632.86

Identifiers

DOI

1 reference

PubMed ID

15209164

Dimensions Publication ID

23 July 2017

0 references

1 reference

PubMed ID

15209164