Wound-healing studies in transgenic and knockout mice (Q33207820)

23 July 2017

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title

Wound-healing studies in transgenic and knockout mice (English)

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23 July 2017

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2

Sabine Werner

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23 July 2017

Richard Grose

1

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23 July 2017

1 October 2004

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23 July 2017

Molecular Biotechnology

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23 July 2017

28

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23 July 2017

2

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23 July 2017

147-166

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https://scigraph.springernature.com/pub.10.1385/mb:28:2:147

23 July 2017

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cites work

Delayed wound repair and impaired angiogenesis in mice lacking syndecan-4

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12 December 2020

The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin

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12 December 2020

Normal development, wound healing, and adenovirus susceptibility in beta5-deficient mice

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12 December 2020

Role of endothelial selectins in wound repair

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12 December 2020

A role for skin gammadelta T cells in wound repair

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12 December 2020

Urokinase-type plasminogen activator is effective in fibrin clearance in the absence of its receptor or tissue-type plasminogen activator

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12 December 2020

Smads: transcriptional activators of TGF-beta responses

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12 December 2020

Development of gene-switch transgenic mice that inducibly express transforming growth factor beta1 in the epidermis

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12 December 2020

Multiple chemotactic factors: fine control or redundancy?

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12 December 2020

Cutaneous tissue repair: practical implications of current knowledge. II.

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12 December 2020

Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice

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12 December 2020

Loss of Smad3 modulates wound healing

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12 December 2020

Characterization of incisional wound healing in inducible nitric oxide synthase knockout mice

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12 December 2020

E2F-1 is essential for normal epidermal wound repair

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12 December 2020

Accelerated wound healing in tumor necrosis factor receptor p55-deficient mice with reduced leukocyte infiltration

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12 December 2020

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

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12 December 2020

Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene

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12 December 2020

Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog

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12 December 2020

Critical roles of PPAR beta/delta in keratinocyte response to inflammation

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12 December 2020

Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases

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12 December 2020

Impaired wound contraction in stromelysin-1-deficient mice

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12 December 2020

Maternal rescue of transforming growth factor-beta 1 null mice

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12 December 2020

Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferation

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12 December 2020

Neutralising antibody to TGF-beta 1,2 reduces cutaneous scarring in adult rodents

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12 December 2020

Wound-healing defects in mice lacking fibrinogen

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12 December 2020

Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions.

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12 December 2020

Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5.

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12 December 2020

Recombinant basic fibroblast growth factor accelerates wound healing

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12 December 2020

Functional analysis of activins during mammalian development.

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12 December 2020

Incisional wound healing in transforming growth factor-beta1 null mice.

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12 December 2020

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

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12 December 2020

Keratinocyte-specific expression of human thrombomodulin in transgenic mice: effects on epidermal differentiation and cutaneous wound healing

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12 December 2020

Physiological consequences of loss of plasminogen activator gene function in mice

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12 December 2020

Compensation by fibroblast growth factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice.

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12 December 2020

Impaired wound healing in mice with a disrupted plasminogen gene

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12 December 2020

A role for endogenous glucocorticoids in wound repair

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12 December 2020

Deletion of neuropeptide Y (NPY) 2 receptor in mice results in blockage of NPY-induced angiogenesis and delayed wound healing

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12 December 2020

Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis

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12 December 2020

Immediate early genes krox-24 and krox-20 are rapidly up-regulated after wounding in the embryonic and adult mouse

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12 December 2020

Mice lacking the thrombin receptor, PAR1, have normal skin wound healing.

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12 December 2020

Perfect wound healing in the keratin 8 deficient mouse embryo

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12 December 2020

Matrix metalloproteinase gelatinase B (MMP-9) coordinates and effects epithelial regeneration

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12 December 2020

Overexpression of bone morphogenetic protein-6 (BMP-6) in the epidermis of transgenic mice: inhibition or stimulation of proliferation depending on the pattern of transgene expression and formation of psoriatic lesions

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12 December 2020

Inhibition of PDGF β Receptor Signal Transduction by Coexpression of a Truncated Receptor

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12 December 2020

Hoxb13 knockout adult skin exhibits high levels of hyaluronan and enhanced wound healing

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12 December 2020

Basic fibroblast growth factor stimulation of epidermal wound healing in pigs

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12 December 2020

Mouse fibroblast growth factor 10: cDNA cloning, protein characterization, and regulation of mRNA expression

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12 December 2020

Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2.

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12 December 2020

Chemokine and inflammatory cytokine changes during chronic wound healing

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12 December 2020

Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes

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12 December 2020

The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts

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12 December 2020

Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis.

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12 December 2020

Functions of the POU domain genes Skn-1a/i and Tst-1/Oct-6/SCIP in epidermal differentiation

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12 December 2020

Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan

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12 December 2020

Spatial and temporal patterns of immunoreactive transforming growth factor beta 1, beta 2, and beta 3 during excisional wound repair.

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12 December 2020

In vivo introduction of the interleukin 6 gene into human keratinocytes: induction of epidermal proliferation by the fully spliced form of interleukin 6, but not by the alternatively spliced form

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12 December 2020

Epithelial wound healing enhanced by transforming growth factor-alpha and vaccinia growth factor

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12 December 2020

Overexpression of hepatocyte growth factor/scatter factor promotes vascularization and granulation tissue formation in vivo

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12 December 2020

Platelet-derived growth factor B-chain of hematopoietic origin is not necessary for granulation tissue formation and its absence enhances vascularization

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12 December 2020

Loss of fibrinogen rescues mice from the pleiotropic effects of plasminogen deficiency.

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12 December 2020

The alpha(2) integrin subunit-deficient mouse: a multifaceted phenotype including defects of branching morphogenesis and hemostasis

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12 December 2020

Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2

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12 December 2020

Healing of burn wounds in transgenic mice overexpressing transforming growth factor-beta 1 in the epidermis

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12 December 2020

A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization

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12 December 2020

Accelerated skin wound healing in plasminogen activator inhibitor-1-deficient mice

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12 December 2020

Vitronectin deficiency is associated with increased wound fibrinolysis and decreased microvascular angiogenesis in mice

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12 December 2020

Structural and functional diversity in the FGF receptor multigene family

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12 December 2020

Mice with a null mutation of the TGF alpha gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation.

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12 December 2020

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

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12 December 2020

The Nf1 tumor suppressor regulates mouse skin wound healing, fibroblast proliferation, and collagen deposited by fibroblasts

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12 December 2020

Facilitated wound healing by activation of the Transglutaminase 1 gene

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12 December 2020

Biological roles of fibroblast growth factor-2.

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12 December 2020

Epidermal expression of collagenase delays wound-healing in transgenic mice.

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12 December 2020

Development, characterization, and wound healing of the keratin 14 promoted transforming growth factor-beta1 transgenic mouse

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12 December 2020

Monospecific antibodies implicate basic fibroblast growth factor in normal wound repair

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12 December 2020

Recombinant basic fibroblast growth factor stimulates wound healing in healing-impaired db/db mice

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12 December 2020

Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.

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12 December 2020

Delayed wound healing and disorganized neovascularization in transgenic mice expressing the IP-10 chemokine.

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12 December 2020

Altered wound healing in mice lacking a functional osteopontin gene (spp1).

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12 December 2020

TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice.

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12 December 2020

Thrombospondin-1 suppresses wound healing and granulation tissue formation in the skin of transgenic mice

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12 December 2020

Can't get no SMADisfaction: Smad proteins as positive and negative regulators of TGF-beta family signals

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12 December 2020

Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound

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12 December 2020

Role of elevated plasma transforming growth factor-beta1 levels in wound healing

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12 December 2020

Conditional gene targeting

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12 December 2020

Impaired wound healing and angiogenesis in eNOS-deficient mice

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12 December 2020

Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment

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12 December 2020

Delayed wound healing in immunodeficient TGF-beta 1 knockout mice

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12 December 2020

Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure

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12 December 2020

TGF-beta signal transduction

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12 December 2020

Chemokines IL-8, GROalpha, MCP-1, IP-10, and Mig are sequentially and differentially expressed during phase-specific infiltration of leukocyte subsets in human wound healing

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12 December 2020

Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development

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12 December 2020

Activation of STAT proteins and growth control

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12 December 2020

Impaired wound healing in embryonic and adult mice lacking vimentin.

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12 December 2020

The transforming growth factor-beta family

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12 December 2020

Keratinocyte growth factor is required for hair development but not for wound healing

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12 December 2020

Reduction in fibrotic tissue formation in mice genetically deficient in plasminogen activator inhibitor-1.

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12 December 2020

Basic Fibroblast Growth Factor in the Early Human Burn Wound

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12 December 2020

Skin wounds and severed nerves heal normally in mice lacking tenascin-C

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12 December 2020

The function of KGF in morphogenesis of epithelium and reepithelialization of wounds

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12 December 2020

Resistance of keratinocytes to TGFbeta-mediated growth restriction and apoptosis induction accelerates re-epithelialization in skin wounds.

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12 December 2020

TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway

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12 December 2020

Is impaired wound healing caused by infection or nutritional depletion?

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12 December 2020

Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development

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12 December 2020

c-Jun regulates eyelid closure and skin tumor development through EGFR signaling

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12 December 2020

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

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12 December 2020

Wound epithelialization deficits in the transforming growth factor-alpha knockout mouse

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12 December 2020

Multiple defects and perinatal death in mice deficient in follistatin

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12 December 2020

Fetal wound repair results in scar formation in interleukin-10-deficient mice in a syngeneic murine model of scarless fetal wound repair

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12 December 2020

Wound healing in the PU.1 null mouse--tissue repair is not dependent on inflammatory cells.

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12 December 2020

Overexpression of activin A in the skin of transgenic mice reveals new activities of activin in epidermal morphogenesis, dermal fibrosis and wound repair

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12 December 2020

Accelerated wound healing in mice with a disruption of the thrombospondin 2 gene.

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12 December 2020

Transcriptional control by the TGF-beta/Smad signaling system

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12 December 2020

Large induction of keratinocyte growth factor expression in the dermis during wound healing

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12 December 2020

Impaired wound healing in transgenic mice overexpressing the activin antagonist follistatin in the epidermis

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12 December 2020

Appearance of heparin-binding EGF-like growth factor in wound fluid as a response to injury

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12 December 2020

Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing

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12 December 2020

Defects in keratinocyte activation during wound healing in the syndecan-1-deficient mouse

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12 December 2020

Interleukin-6 and the skin

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12 December 2020

Wound healing in MIP-1alpha(-/-) and MCP-1(-/-) mice

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12 December 2020

Biological effects of targeted inactivation of hepatocyte growth factor-like protein in mice

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12 December 2020

Strain-dependent epithelial defects in mice lacking the EGF receptor

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12 December 2020

Fibroblast growth factor signalling in the hair growth cycle: expression of the fibroblast growth factor receptor and ligand genes in the murine hair follicle

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12 December 2020

Strong induction of activin expression after injury suggests an important role of activin in wound repair

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12 December 2020

Transforming growth factors beta1, beta2, and beta3 and their receptors are differentially regulated during normal and impaired wound healing

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12 December 2020

Evidence for epidermal growth factor (EGF)-induced intermolecular autophosphorylation of the EGF receptors in living cells

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12 December 2020

Neutralisation of TGF-beta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring

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12 December 2020

Delayed wound healing in CXCR2 knockout mice

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12 December 2020

Structure and expression of the rat mRNA encoding a novel member of the fibroblast growth factor family.

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12 December 2020

Lack of a significant effect of deletion of the tachykinin neurokinin-1 receptor on wound healing in mouse skin

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12 December 2020

c-Jun is essential for organization of the epidermal leading edge

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12 December 2020

A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair

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12 December 2020

Cell migration is essential for sustained growth of keratinocyte colonies: the roles of transforming growth factor-alpha and epidermal growth factor

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12 December 2020

Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor

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12 December 2020

Disruption of protein kinase Ceta results in impairment of wound healing and enhancement of tumor formation in mouse skin carcinogenesis.

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12 December 2020

Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration

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12 December 2020

Modulation of keratinocyte growth factor and its receptor in reepithelializing human skin.

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12 December 2020

Altered connexin expression and wound healing in the epidermis of connexin-deficient mice

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12 December 2020

Impaired cutaneous wound healing in interleukin-6-deficient and immunosuppressed mice

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12 December 2020

Wound healing in the transforming growth factor-beta-deficient mouse.

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12 December 2020

Induction of bone morphogenetic protein-6 in skin wounds. Delayed reepitheliazation and scar formation in BMP-6 overexpressing transgenic mice

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12 December 2020

Delayed wound healing in keratin 6a knockout mice

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12 December 2020

Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer

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12 December 2020

The plasminogen activator inhibitor-2 gene is not required for normal murine development or survival

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12 December 2020

Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation

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12 December 2020

Augmented inflammatory responses and altered wound healing in cathepsin G-deficient mice

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12 December 2020

Wound healing--aiming for perfect skin regeneration

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12 December 2020

Cdk4 deficiency inhibits skin tumor development but does not affect normal keratinocyte proliferation

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12 December 2020

Analysis of the tissue movements of embryonic wound healing--DiI studies in the limb bud stage mouse embryo

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12 December 2020

Essential involvement of IL-6 in the skin wound-healing process as evidenced by delayed wound healing in IL-6-deficient mice.

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12 December 2020

Keratinocyte-derived granulocyte-macrophage colony stimulating factor accelerates wound healing: Stimulation of keratinocyte proliferation, granulation tissue formation, and vascularization

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12 December 2020

Receptor binding and mitogenic properties of mouse fibroblast growth factor 3. Modulation of response by heparin

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12 December 2020

Identifiers

DOI

10.1385/MB:28:2:147

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PubMed ID

15477654

Dimensions Publication ID

23 July 2017

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1 reference

PubMed ID

15477654