Mimicking natural evolution in metallo-beta-lactamases through second-shell ligand mutations (Q33223608)

24 July 2017

Mimicking natural evolution in metallo-beta-lactamases through second-shell ligand mutations (English)

1 reference

24 July 2017

Lorenzo Segovia

3

0 references

author name string

Pablo E Tomatis

series ordinal

1

1 reference

24 July 2017

Rodolfo M Rasia

series ordinal

2

1 reference

24 July 2017

Alejandro J Vila

series ordinal

4

1 reference

24 July 2017

language of work or name

English

0 references

publication date

19 September 2005

1 reference

Proceedings of the National Academy of Sciences of the United States of America

24 July 2017

1 reference

24 July 2017

102

1 reference

24 July 2017

39

1 reference

24 July 2017

13761-13766

1 reference

Effect of pH on the active site of an Arg121Cys mutant of the metallo-beta-lactamase from Bacillus cereus: implications for the enzyme mechanism

24 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236536

Direct evidence that the reaction intermediate of metallo-beta-lactamase L1 is metal bound.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236536

Metallo-beta-lactamases: two binding sites for one catalytic metal ion?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236536

Resistance to beta-lactam antibiotics

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236536

A perspective on enzyme catalysis.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236536

Biochemical characterization of beta-lactamases Bla1 and Bla2 from Bacillus anthracis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236536

The 1.5-A structure of Chryseobacterium meningosepticum zinc beta-lactamase in complex with the inhibitor, D-captopril

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236536

Drug resistance in HIV-1 protease: Flexibility-assisted mechanism of compensatory mutations

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236536

Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236536

The structural bases of antibiotic resistance in the clinically derived mutant beta-lactamases TEM-30, TEM-32, and TEM-34

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236536

Mutational analysis of the two zinc-binding sites of the Bacillus cereus 569/H/9 metallo-beta-lactamase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236536

Mutant TEM beta-lactamase producing resistance to ceftazidime, ampicillins, and beta-lactamase inhibitors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236536

Succinic acids as potent inhibitors of plasmid-borne IMP-1 metallo-beta-lactamase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236536

Predicting the emergence of antibiotic resistance by directed evolution and structural analysis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236536

The problem of a solvent exposable disulfide when preparing Co(II)-substituted metallo-beta-lactamase L1 from Stenotrophomonas maltophilia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236536

Standard numbering scheme for class B beta-lactamases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236536

Amino acid substitutions in a variant of IMP-1 metallo-beta-lactamase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236536

Crystal structure of the IMP-1 metallo beta-lactamase from Pseudomonas aeruginosa and its complex with a mercaptocarboxylate inhibitor: binding determinants of a potent, broad-spectrum inhibitor

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236536

Metallo-beta-lactamase: structure and mechanism

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236536

Mono- and binuclear Zn2+-beta-lactamase. Role of the conserved cysteine in the catalytic mechanism

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236536

The crystal structure of the L1 metallo-beta-lactamase from Stenotrophomonas maltophilia at 1.7 A resolution

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236536

Crystal structure of the zinc-dependent beta-lactamase from Bacillus cereus at 1.9 A resolution: binuclear active site with features of a mononuclear enzyme

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236536

Spectroscopic characterization of a binuclear metal site in Bacillus cereus beta-lactamase II.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236536

DNA shuffling of a family of genes from diverse species accelerates directed evolution

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236536

Crystal structure of the wide-spectrum binuclear zinc beta-lactamase from Bacteroides fragilis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236536

Rapid evolution of a protein in vitro by DNA shuffling

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236536

The 3-D structure of a zinc metallo-beta-lactamase from Bacillus cereus reveals a new type of protein fold

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236536

Beta-lactamases and bacterial resistance to antibiotics

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236536

High spin cobalt(II) as a probe for the investigation of metalloproteins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236536

The use of 4-(2-pyridylazo)resorcinol in studies of zinc release from Escherichia coli aspartate transcarbamoylase.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236536

Bacterial resistance to beta-lactam antibiotics: compelling opportunism, compelling opportunity

28 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0503495102

A metallo-beta-lactamase enzyme in action: crystal structures of the monozinc carbapenemase CphA and its complex with biapenem

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0503495102

Three-dimensional structure of FEZ-1, a monomeric subclass B3 metallo-beta-lactamase from Fluoribacter gormanii, in native form and in complex with D-captopril

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0503495102

Exploring the role and the binding affinity of a second zinc equivalent in B. cereus metallo-beta-lactamase

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0503495102

Structural determinants and hydrogen-bond network of the mononuclear zinc(II)-beta-lactamase active site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0503495102

Water-assisted reaction mechanism of monozinc beta-lactamases

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0503495102

DNA shuffling by random fragmentation and reassembly: in vitro recombination for molecular evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0503495102

Evolutionary engineering of a beta-Lactamase activity on a D-Ala D-Ala transpeptidase fold.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0503495102

Modeling domino effects in enzymes: molecular basis of the substrate specificity of the bacterial metallo-beta-lactamases IMP-1 and IMP-6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0503495102

Impact of remote mutations on metallo-beta-lactamase substrate specificity: implications for the evolution of antibiotic resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0503495102

Structural determinants of substrate binding to Bacillus cereus metallo-beta-lactamase

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0503495102

Novel mechanism of hydrolysis of therapeutic beta-lactams by Stenotrophomonas maltophilia L1 metallo-beta-lactamase

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0503495102

Substrate binding to mononuclear metallo-beta-lactamase from Bacillus cereus

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0503495102

Analysis of the context dependent sequence requirements of active site residues in the metallo-beta-lactamase IMP-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0503495102

The mechanism of catalysis and the inhibition of the Bacillus cereus zinc-dependent beta-lactamase

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1236536

Metal ion binding and coordination geometry for wild type and mutants of metallo-beta -lactamase from Bacillus cereus 569/H/9 (BcII): a combined thermodynamic, kinetic, and spectroscopic approach

31 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16172409

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Role of conformational fluctuations in the enzymatic reaction of HIV-1 protease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16172409

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0503495102

1 reference

24 July 2017

0 references

1 reference

24 July 2017

1 reference