Analysis of coumarin 7-hydroxylation activity of cytochrome P450 2A6 using random mutagenesis (Q33224655)

24 July 2017

title

Analysis of coumarin 7-hydroxylation activity of cytochrome P450 2A6 using random mutagenesis (English)

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24 July 2017

Zhong-Liu Wu

2

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author name string

Donghak Kim

series ordinal

1

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24 July 2017

F Peter Guengerich

series ordinal

3

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24 July 2017

language of work or name

English

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publication date

5 October 2005

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Journal of Biological Chemistry

24 July 2017

number of pages

9

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based on heuristic

inferred from page(s)

published in

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24 July 2017

volume

280

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24 July 2017

issue

48

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24 July 2017

page(s)

40319-40327

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Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity

24 July 2017

cites work

1 reference

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The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes

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Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity

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Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes

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Human cytochrome P450 2A6 is the major enzyme involved in the metabolism of three alkoxyethers used as oxyfuels

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Kinetic analysis of the activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by heterologously expressed human P450 enzymes and the effect of P450-specific chemical inhibitors on this activation in human liver microsomes

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Nicotine metabolism defect reduces smoking

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Oxidation of indole by cytochrome P450 enzymes

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Random mutagenesis of human cytochrome p450 2A6 and screening with indole oxidation products

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21 January 2018

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21 January 2018

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21 January 2018

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Rate-determining steps in phenacetin oxidations by human cytochrome P450 1A2 and selected mutants

21 January 2018

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The colorimetric estimation of formaldehyde by means of the Hantzsch reaction

21 January 2018

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Expansion of substrate specificity of cytochrome P450 2A6 by random and site-directed mutagenesis

21 January 2018

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Covalent linkage of prosthetic heme to CYP4 family P450 enzymes

21 January 2018

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Flavocytochrome P450 BM3 mutant A264E undergoes substrate-dependent formation of a novel heme iron ligand set.

21 January 2018

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Interactions of mammalian cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b(5) enzymes

21 January 2018

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Identification of Val117 and Arg372 as critical amino acid residues for the activity difference between human CYP2A6 and CYP2A13 in coumarin 7-hydroxylation

21 January 2018

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Selection of human cytochrome P450 1A2 mutants with enhanced catalytic activity for heterocyclic amine N-hydroxylation

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21 January 2018

Identifiers

DOI

10.1074/JBC.M508171200

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24 July 2017

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