Locked nucleoside analogues expand the potential of DNAzymes to cleave structured RNA targets (Q33245746)

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29 January 2020

title

Locked nucleoside analogues expand the potential of DNAzymes to cleave structured RNA targets (English)

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29 January 2020

1

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29 January 2020

Jesper Wengel

6

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29 January 2020

Stephen Douthwaite

7

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29 January 2020

author name string

Lykke H Hansen

2

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29 January 2020

Lars Bo Lundberg

3

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29 January 2020

B Ravindra Babu

4

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29 January 2020

Mads D Sørensen

5

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29 January 2020

publication date

5 June 2006

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29 January 2020

published in

BMC Molecular Biology

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29 January 2020

volume

7

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29 January 2020

page(s)

19

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Evaluation of LNA-modified DNAzymes targeting a single nucleotide polymorphism in the large subunit of RNA polymerase II.

29 January 2020

cites work

1 reference

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Structures of the bacterial ribosome at 3.5 A resolution

21 June 2018

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DNAzyme-mediated silencing of ornithine decarboxylase.

21 June 2018

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LNA (locked nucleic acid): high-affinity targeting of complementary RNA and DNA.

21 June 2018

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Locked nucleic acid modified DNA enzymes targeting early growth response-1 inhibit human vascular smooth muscle cell growth

21 June 2018

1 reference

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RNA cleaving '10-23' DNAzymes with enhanced stability and activity

21 June 2018

1 reference

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Structural rearrangements of the 10-23 DNAzyme to beta 3 integrin subunit mRNA induced by cations and their relations to the catalytic activity

21 June 2018

1 reference

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A common speed limit for RNA-cleaving ribozymes and deoxyribozymes

21 June 2018

1 reference

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Optimisation of the 10-23 DNAzyme-substrate pairing interactions enhanced RNA cleavage activity at purine-cytosine target sites

21 June 2018

1 reference

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Structure of 23S rRNA hairpin 35 and its interaction with the tylosin-resistance methyltransferase RlmAII.

21 June 2018

1 reference

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alpha-L-LNA (alpha-L-ribo configured locked nucleic acid) recognition of DNA: an NMR spectroscopic study

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501032

Locked nucleic acid (LNA) recognition of RNA: NMR solution structures of LNA:RNA hybrids

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501032

alpha-L-ribo-configured locked nucleic acid (alpha-L-LNA): synthesis and properties

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501032

Comparative study of DNA enzymes and ribozymes against the same full-length messenger RNA of the vanilloid receptor subtype I.

21 June 2018

1 reference

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DNAzymes to beta 1 and beta 3 mRNA down-regulate expression of the targeted integrins and inhibit endothelial cell capillary tube formation in fibrin and matrigel

21 June 2018

1 reference

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Recognition of nucleotide G745 in 23 S ribosomal RNA by the rrmA methyltransferase

21 June 2018

1 reference

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The influence of arm length asymmetry and base substitution on the activity of the 10-23 DNA enzyme.

21 June 2018

1 reference

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The complete atomic structure of the large ribosomal subunit at 2.4 A resolution

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501032

A detailed view of a ribosomal active site: the structure of the L11-RNA complex

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501032

Crystal structure of a conserved ribosomal protein-RNA complex

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501032

Mechanism and utility of an RNA-cleaving DNA enzyme

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501032

Effects of helical structures formed by the binding arms of DNAzymes and their substrates on catalytic activity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501032

A general purpose RNA-cleaving DNA enzyme

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501032

Isolation of mutants of Escherichia coli lac king 5-methyluracil in transfer ribonucleic acid or 1-methylguanine in ribosomal RNA.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501032

Antibiotic resistance mutations in ribosomal RNA genes of Escherichia coli.

21 June 2018

1 reference

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Structural analysis of RNA using chemical and enzymatic probing monitored by primer extension

21 June 2018

1 reference

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Characterization of the binding sites of protein L11 and the L10.(L12)4 pentameric complex in the GTPase domain of 23 S ribosomal RNA from Escherichia coli

21 June 2018

1 reference

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Gaining target access for deoxyribozymes.

21 June 2018

1 reference

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LNAzymes: incorporation of LNA-type monomers into DNAzymes markedly increases RNA cleavage.

31 October 2018

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Design of nuclease resistant protein kinase calpha DNA enzymes with potential therapeutic application.

31 October 2018

1 reference

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Target site selection for an RNA-cleaving catalytic DNA

31 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16753066

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Suppression of smooth muscle cell proliferation by a c-myc RNA-cleaving deoxyribozyme

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16753066

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1471-2199-7-19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16753066%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

29 January 2020

0 references

1 reference

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29 January 2020

PubMed publication ID

16753066

1 reference