Protein and small molecule microarrays: powerful tools for high-throughput proteomics (Q33252427)

24 July 2017

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title

Protein and small molecule microarrays: powerful tools for high-throughput proteomics (English)

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24 July 2017

Jun Wang

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author name string

Mahesh Uttamchandani

series ordinal

1

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PubMed ID

16880923

24 July 2017

Shao Q Yao

series ordinal

3

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24 July 2017

25 November 2005

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24 July 2017

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24 July 2017

2

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24 July 2017

1

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24 July 2017

58-68

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Array-based technologies and their applications in proteomics

24 July 2017

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Protein microarrays as tools for functional proteomics

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Protein-detecting microarrays: current accomplishments and requirements.

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Recent developments in protein microarray technology

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Membrane protein microarrays.

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Fluorous-based carbohydrate microarrays

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Peptide arrays: towards routine implementation

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Tissue microarrays for high-throughput molecular profiling of tumor specimens

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Microarrays of cells expressing defined cDNAs

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Small molecule microarrays: recent advances and applications

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Protein biochips: the calm before the storm

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Global analysis of protein activities using proteome chips

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Global analysis of protein function using protein microarrays

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Functional protein microarrays: just how functional are they?

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Intein-mediated biotinylation of proteins and its application in a protein microarray

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Versatile protein biotinylation strategies for potential high-throughput proteomics

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Chemoselective attachment of biologically active proteins to surfaces by expressed protein ligation and its application for "protein chip" fabrication

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Functional GPCR microarrays.

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Development of a protein microarray using sequence-specific DNA binding domain on DNA chip surface

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Self-assembling protein microarrays

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Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips

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Regulation of gene expression by a metabolic enzyme

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Functional protein microarrays for parallel characterisation of p53 mutants

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Comprehensive identification of human bZIP interactions with coiled-coil arrays

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Analysis of leukocyte membrane protein interactions using protein microarrays

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Protein microarrays for antibody profiling: specificity and affinity determination on a chip

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Estrogen receptor microarrays: subtype-selective ligand binding

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Developing a strategy for activity-based detection of enzymes in a protein microarray

21 January 2018

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Enzyme microarrays: On-chip determination of inhibition constants based on affinity-label detection of enzymatic activity.

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A functional protein chip for pathway optimization and in vitro metabolic engineering

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Nanometric protein arrays on protein-resistant monolayers on silicon surfaces

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Bioactive protein nanoarrays on nickel oxide surfaces formed by dip-pen nanolithography.

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Label-free reading of microarray-based immunoassays with surface plasmon resonance imaging.

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A novel approach to protein expression profiling using antibody microarrays combined with surface plasmon resonance technology

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Sensitivity of ex situ and in situ spectral surface plasmon resonance sensors in the analysis of protein arrays.

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Analysis of protein interactions on protein arrays by a wavelength interrogation-based surface plasmon resonance biosensor

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Label-free detection of protein-protein interactions on biochips

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Preparing protein microarrays by soft-landing of mass-selected ions

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Preparative linear ion trap mass spectrometer for separation and collection of purified proteins and peptides in arrays using ion soft landing

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A one-bead, one-stock solution approach to chemical genetics: part 2.

21 January 2018

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A one-bead, one-stock solution approach to chemical genetics: part 1.

21 January 2018

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Split--pool synthesis of 1,3-dioxanes leading to arrayed stock solutions of single compounds sufficient for multiple phenotypic and protein-binding assays

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Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays.

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Skeletal diversity via a branched pathway: efficient synthesis of 29 400 discrete, polycyclic compounds and their arraying into stock solutions.

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Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis

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Diversity-oriented synthesis of biaryl-containing medium rings using a one bead/one stock solution platform

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Asymmetric Catalysis in Diversity-Oriented Organic Synthesis: Enantioselective Synthesis of 4320 Encoded and Spatially Segregated Dihydropyrancarboxamides We thank the National Institute of General Medical Sciences (GM-52067) for support of this res

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Microarrays of tagged combinatorial triazine libraries in the discovery of small-molecule ligands of human IgG.

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A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening

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Novel orthogonal strategy toward solid-phase synthesis of 1,3,5-substituted triazines

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Profiling protein function with small molecule microarrays

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Synthesis and evaluation of peptidyl Michael acceptors that inactivate human rhinovirus 3C protease and inhibit virus replication.

21 January 2018

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Staudinger ligation: a new immobilization strategy for the preparation of small-molecule arrays

21 January 2018

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Development of chemically modified glass surfaces for nucleic acid, protein and small molecule microarrays

21 January 2018

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A photochemical method for patterning the immobilization of ligands and cells to self-assembled monolayers

21 January 2018

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Immobilization of natural products on glass slides by using a photoaffinity reaction and the detection of protein-small-molecule interactions

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Light-directed radial combinatorial chemistry: orthogonal safety-catch protecting groups for the synthesis of small molecule microarrays

21 January 2018

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Photolithographic synthesis of peptoids

21 January 2018

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Modular synthesis and preliminary biological evaluation of stereochemically diverse 1,3-dioxanes.

21 January 2018

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Construction of a protein-detection system using a loop peptide library with a fluorescence label

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Protein "fingerprinting" in complex mixtures with peptoid microarrays

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Peptide microarrays for the determination of protease substrate specificity

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Printing chemical libraries on microarrays for fluid phase nanoliter reactions

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Profiling serine protease substrate specificity with solution phase fluorogenic peptide microarrays

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Nanodroplet profiling of enzymatic activities in a microarray.

21 January 2018

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Subnanoliter enzymatic assays on microarrays.

21 January 2018

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PNA-encoded protease substrate microarrays.

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Activity profile of dust mite allergen extract using substrate libraries and functional proteomic microarrays

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Phagemid encoded small molecules for high throughput screening of chemical libraries

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Encoded self-assembling chemical libraries

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Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells.

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Microarrays of small molecules embedded in biodegradable polymers for use in mammalian cell-based screens.

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Metabolizing enzyme toxicology assay chip (MetaChip) for high-throughput microscale toxicity analyses

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Spot-synthesis: an easy technique for the positionally addressable, parallel chemical synthesis on a membrane support

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Diversity-oriented synthesis; a challenge for synthetic chemistsElectronic supplementary information (ESI) available: Excel file of all the FDA new molecular entities between the years 1998 and July 2003, and new drug approvals between the years 1990

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Palladium-catalyzed cross-coupling reaction of resin-bound chlorotriazines

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21 January 2018

Identifiers

DOI

10.1039/B513935J

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24 July 2017

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PubMed ID

16880923