Just-in-time purification: an effective solution for cherry-picking and purifying active compounds from large legacy libraries (Q33263080)

24 July 2017

title

Just-in-time purification: an effective solution for cherry-picking and purifying active compounds from large legacy libraries (English)

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24 July 2017

Christina Guintu

1

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24 July 2017

Michael Kwok

2

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James J Hanlon

3

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24 July 2017

Tracy A Spalding

4

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Karen Wolff

5

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Hong Yin

6

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Kelli Kuhen

7

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Kimberly Sasher

8

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Paul Calvin

9

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Shumei Jiang

10

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Yingyao Zhou

11

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John J Isbell

12

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24 July 2017

publication date

7 November 2006

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Journal of Biomolecular Screening

24 July 2017

published in

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24 July 2017

volume

11

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24 July 2017

issue

8

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24 July 2017

page(s)

933-939

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Development of a custom high-throughput preparative liquid chromatography/mass spectrometer platform for the preparative purification and analytical analysis of compound libraries

24 July 2017

cites work

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Purifying the masses: integrating prepurification quality control, high-throughput LC/MS purification, and compound plating to feed high-throughput screening

21 January 2018

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Streamlined system for purifying and quantifying a diverse library of compounds and the effect of compound concentration measurements on the accurate interpretation of biological assay results

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21 January 2018

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UV-triggered main-component fraction collection method and its application for high-throughput chromatographic purification of combinatorial libraries.

21 January 2018

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21 January 2018

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Realities of high-throughput liquid chromatography/mass spectrometry purification of large combinatorial libraries: a report on overall sample throughput using parallel purification

21 January 2018

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The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

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SXR, a novel steroid and xenobiotic-sensing nuclear receptor

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Homogeneous high-throughput screening assays for HIV-1 integrase 3beta-processing and strand transfer activities

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Combinatonial chemistry and mass spectrometry in the 21st century drug discovery laboratory

21 January 2018

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Quality control in combinatorial chemistry: determination of the quantity, purity, and quantitative purity of compounds in combinatorial libraries

21 January 2018

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Quality control in combinatorial chemistry: determinations of amounts and comparison of the "purity" of LC-MS-purified samples by NMR, LC-UV and CLND.

21 January 2018

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Parallel preparative high-performance liquid chromatography with on-line molecular mass characterization

21 January 2018

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21 January 2018

Identifiers

DOI

10.1177/1087057106294289

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24 July 2017

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