A simple, no-wash cell adhesion-based high-throughput assay for the discovery of small-molecule regulators of the integrin CD11b/CD18 (Q33282239)

25 July 2017

title

A simple, no-wash cell adhesion-based high-throughput assay for the discovery of small-molecule regulators of the integrin CD11b/CD18 (English)

1 reference

25 July 2017

1 reference

3

Vineet Gupta

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25 July 2017

Jun Y Park

1

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25 July 2017

M Amin Arnaout

series ordinal

2

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25 July 2017

publication date

1 April 2007

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Journal of Biomolecular Screening

25 July 2017

published in

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25 July 2017

volume

12

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25 July 2017

issue

3

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25 July 2017

page(s)

406-417

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The beta-tail domain (betaTD) regulates physiologic ligand binding to integrin CD11b/CD18

25 July 2017

cites work

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Stabilization of the activated alphaMbeta2 integrin by a small molecule inhibits leukocyte migration and recruitment

21 June 2018

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21 June 2018

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Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2/Mac-1 is critical for host inflammatory response in vivo

21 June 2018

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New insights into the structural basis of integrin activation.

21 June 2018

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A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins

21 June 2018

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Integrins: bidirectional, allosteric signaling machines

21 June 2018

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Integrin structure: new twists and turns in dynamic cell adhesion

21 June 2018

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Small molecule inhibitors induce conformational changes in the I domain and the I-like domain of lymphocyte function-associated antigen-1. Molecular insights into integrin inhibition

21 June 2018

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CD18 activation epitopes induced by leukocyte activation

21 June 2018

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Epitope mapping of antibodies to the C-terminal region of the integrin beta 2 subunit reveals regions that become exposed upon receptor activation

21 June 2018

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An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11b A-domain

21 June 2018

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

21 June 2018

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Ligand binding to integrins

21 June 2018

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Decreased neointimal formation in Mac-1(-/-) mice reveals a role for inflammation in vascular repair after angioplasty

21 June 2018

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Functional analysis of the beta 2 integrins

21 June 2018

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Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain

21 June 2018

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A novel leukocyte adhesion deficiency caused by expressed but nonfunctional beta2 integrins Mac-1 and LFA-1.

21 June 2018

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Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury

21 June 2018

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A mAb to the beta2-leukocyte integrin Mac-1 (CD11b/CD18) reduces intimal thickening after angioplasty or stent implantation in rabbits

21 June 2018

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Peptides derived from the complementarity-determining regions of anti-Mac-1 antibodies block intercellular adhesion molecule-1 interaction with Mac-1.

21 June 2018

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A role for Mac-1 (CDIIb/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcgamma receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritis

21 June 2018

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CD18 adhesion blockade decreases bacterial clearance and neutrophil recruitment after intrapulmonary E. coli, but not after S. aureus.

21 June 2018

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Solvent-accessible residues on the metal ion-dependent adhesion site face of integrin CR3 mediate its binding to the neutrophil inhibitory factor

21 June 2018

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Inhibition of neutrophil adherence improves postischemic ventricular performance of the neonatal heart.

21 June 2018

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Neutrophil inhibitory factor prevents neutrophil-dependent lung injury

21 June 2018

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Antibodies that activate beta 2 integrins can generate different ligand binding states

21 June 2018

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Inhibition of phagocytosis of complement C3- or immunoglobulin G-coated particles and of C3bi binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mol)

21 June 2018

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Identification of the C3bi receptor of human monocytes and macrophages by using monoclonal antibodies

21 June 2018

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Regulated expression of Mg2+ binding epitope on leukocyte integrin alpha subunits

21 June 2018

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Leukocyte adhesion molecules deficiency: its structural basis, pathophysiology and implications for modulating the inflammatory response

21 June 2018

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Neutrophil-induced liver cell injury in endotoxin shock is a CD11b/CD18-dependent mechanism

21 June 2018

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Mac-1, but not LFA-1, uses intercellular adhesion molecule-1 to mediate slow leukocyte rolling in TNF-alpha-induced inflammation

21 June 2018

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Differential roles for beta2 integrins in experimental autoimmune bullous pemphigoid

21 January 2018

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Distinct roles of Mac-1 and its counter-receptors in neonatal obstructive nephropathy

21 January 2018

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Small molecule antagonists of complement receptor type 3 block adhesion and adhesion-dependent oxidative burst in human polymorphonuclear leukocytes

21 January 2018

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Characterization of a conformationally sensitive murine monoclonal antibody directed to the metal ion-dependent adhesion site face of integrin CD11b

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057106299162

21 January 2018

1 reference

12 December 2020

Effect of integrin beta 2 subunit truncations on LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) assembly, surface expression, and function

1 reference

12 December 2020

The beta 2 integrin Mac-1 but not p150,95 associates with Fc gamma RIIA

1 reference

12 December 2020

Functional inactivation of neutrophils with a Mac-1 (CD11b/CD18) monoclonal antibody protects against ischemia-reperfusion injury in rat liver

1 reference

12 December 2020

Mice treated with a leumedin or antibody to Mac-1 to inhibit leukocyte sequestration survive endotoxin challenge

1 reference

12 December 2020

Identifiers

DOI

10.1177/1087057106299162

1 reference

release_jxdpmk232jem7eoohkj5v7iu5a

25 July 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/jxdpmk232jem7eoohkj5v7iu5a

24 November 2022

mapped directly with Wikidata item

PMC publication ID

3075871

1 reference

25 July 2017

1 reference