The small molecule Mek1/2 inhibitor U0126 disrupts the chordamesoderm to notochord transition in zebrafish (Q33328969)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18419805%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

title

The small molecule Mek1/2 inhibitor U0126 disrupts the chordamesoderm to notochord transition in zebrafish (English)

1 reference

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5 January 2020

0 references

1

1 reference

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5 January 2020

Florencia Cavodeassi

2

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5 January 2020

Gabor Szabo

4

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5 January 2020

Zsolt Lele

5

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5 January 2020

author name string

Ferenc Erdélyi

3

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5 January 2020

publication date

17 April 2008

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BMC Developmental Biology

5 January 2020

published in

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5 January 2020

volume

8

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5 January 2020

page(s)

42

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Hedgehog signaling patterns the outgrowth of unpaired skeletal appendages in zebrafish

5 January 2020

cites work

1 reference

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Essential role of lysyl oxidases in notochord development

28 July 2018

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Time-dependent patterning of the mesoderm and endoderm by Nodal signals in zebrafish

28 July 2018

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Chemical genetics suggests a critical role for lysyl oxidase in zebrafish notochord morphogenesis

28 July 2018

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Functions of the MAPK family in vertebrate-development

28 July 2018

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MAPK signalling: ERK5 versus ERK1/2.

28 July 2018

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Distinct functions for ERKs?

28 July 2018

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Artery/vein specification is governed by opposing phosphatidylinositol-3 kinase and MAP kinase/ERK signaling

28 July 2018

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Lysyl oxidase regulates actin filament formation through the p130(Cas)/Crk/DOCK180 signaling complex

28 July 2018

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Activated extracellular signal-regulated kinases are necessary and sufficient to initiate tubulogenesis in renal tubular MDCK strain I cell cysts

28 July 2018

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Regulation of bidirectional melanosome transport by organelle bound MAP kinase

28 July 2018

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In vivo drug discovery in the zebrafish

28 July 2018

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ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions

28 July 2018

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Specification of dorsal telencephalic character by sequential Wnt and FGF signaling

28 July 2018

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Structural and functional diversity of lysyl oxidase and the LOX-like proteins

28 July 2018

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Studies of the mitogen-activated protein kinases and phosphatidylinositol-3 kinase in the lens. 1. The mitogenic and stress responses

28 July 2018

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parachute/n-cadherin is required for morphogenesis and maintained integrity of the zebrafish neural tube

28 July 2018

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The JNK signal transduction pathway

28 July 2018

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p38 MAP kinases: beyond the stress response

28 July 2018

1 reference

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Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway

28 July 2018

1 reference

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Menkes disease and Wilson disease: two sides of the same copper coin. Part I: Menkes disease

28 July 2018

1 reference

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A delicate balance: homeostatic control of copper uptake and distribution

28 July 2018

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Epigenetic inhibition of lysyl oxidase transcription after transformation by ras oncogene

28 July 2018

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Organization and regulation of mitogen-activated protein kinase signaling pathways

28 July 2018

1 reference

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Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta

28 July 2018

1 reference

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MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2359734

Identification of a novel inhibitor of mitogen-activated protein kinase kinase

28 July 2018

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A role for FGF-8 in the dorsoventral patterning of the zebrafish gastrula

28 July 2018

1 reference

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Mutations affecting development of the midline and general body shape during zebrafish embryogenesis.

28 July 2018

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Mutations affecting development of the notochord in zebrafish

28 July 2018

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Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes

28 July 2018

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Mutations affecting cell fates and cellular rearrangements during gastrulation in zebrafish

28 July 2018

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The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio.

28 July 2018

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Regulation of lysyl oxidase by basic fibroblast growth factor in osteoblastic MC3T3-E1 cells

28 July 2018

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Immunohistochemical analysis of the Brachyury protein in wild-type and mutant mouse embryos

28 July 2018

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A synthetic inhibitor of the mitogen-activated protein kinase cascade

28 July 2018

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Expression pattern of the mouse T gene and its role in mesoderm formation

28 July 2018

1 reference

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Action of the Brachyury gene in mouse embryogenesis

28 July 2018

1 reference

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p38 MAPK regulates COPII recruitment.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2359734

Atp7a determines a hierarchy of copper metabolism essential for notochord development

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2359734

Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2359734

Essential and overlapping roles for laminin alpha chains in notochord and blood vessel formation

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2359734

Control of the segmentation process by graded MAPK/ERK activation in the chick embryo

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2359734

Multiple signaling pathways regulate FGF-2-induced retinal ganglion cell neurite extension and growth cone guidance

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2359734

Structure and function of the notochord: an essential organ for chordate development

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2359734

Differential requirements for COPI transport during vertebrate early development

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2359734

Hedgehog and Fgf signaling pathways regulate the development of tphR-expressing serotonergic raphe neurons in zebrafish embryos

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2359734

Sonic hedgehog, secreted by amacrine cells, acts as a short-range signal to direct differentiation and lamination in the zebrafish retina

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2359734

ERK signaling is required for eye-specific retino-geniculate segregation

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2359734

Fgf signalling controls the dorsoventral patterning of the zebrafish embryo

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2359734

Topical treatment with inhibitors of the phosphatidylinositol 3'-kinase/Akt and Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathways reduces melanoma development in severe combined immunodeficient mice

31 October 2018

1 reference

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Angiotensin II induces endothelin-1 gene expression via extracellular signal-regulated kinase pathway in rat aortic smooth muscle cells

31 October 2018

1 reference

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Interplay between FGF, one-eyed pinhead, and T-box transcription factors during zebrafish posterior development

31 October 2018

1 reference

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The zebrafish as a model system in developmental, toxicological and transgenic research.

31 October 2018

1 reference

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Mek2 is dispensable for mouse growth and development

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2359734

A conserved role for the MEK signalling pathway in neural tissue specification and posteriorisation in the invertebrate chordate, the ascidian Ciona intestinalis

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2359734

Zebrafish mutants identify an essential role for laminins in notochord formation.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2359734

ERK and p38 MAP kinase are required for rat renal development

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2359734

Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2359734

The zebrafish glypican knypek controls cell polarity during gastrulation movements of convergent extension

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2359734

Fgf signalling through MAPK cascade is required for development of the subpallial telencephalon in zebrafish embryos.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2359734

Analysis of the zebrafish smoothened mutant reveals conserved and divergent functions of hedgehog activity.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2359734

sprouty4 acts in vivo as a feedback-induced antagonist of FGF signaling in zebrafish

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2359734

Functional interactions of genes mediating convergent extension, knypek and trilobite, during the partitioning of the eye primordium in zebrafish.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2359734

31 October 2018

Getting into the Golgi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2359734

hsp47 and hsp70 gene expression is differentially regulated in a stress- and tissue-specific manner in zebrafish embryos

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2359734

Mutations affecting the formation of the notochord in the zebrafish, Danio rerio

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2359734

A genetic screen for mutations affecting embryogenesis in zebrafish.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2359734

Stages of embryonic development of the zebrafish

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2359734

no tail (ntl) is the zebrafish homologue of the mouse T (Brachyury) gene

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2359734

Analysis of FGF function in normal and no tail zebrafish embryos reveals separate mechanisms for formation of the trunk and the tail.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2359734

Genetic analysis of dorsoventral pattern formation in the zebrafish: requirement of a BMP-like ventralizing activity and its dorsal repressor

31 October 2018

1 reference

12 December 2020

Vesicular transport: the core machinery of COPI recruitment and budding

1 reference

12 December 2020

Induction of muscle pioneers and floor plate is distinguished by the zebrafish no tail mutation

1 reference

12 December 2020

Binary specification of nerve cord and notochord cell fates in ascidian embryos

1 reference

12 December 2020

Effects of U0126 and fibroblast growth factor on gene expression profile in Ciona intestinalis embryos as revealed by microarray analysis

1 reference

12 December 2020

Role of the FGF and MEK signaling pathway in the ascidian embryo

1 reference

12 December 2020

Role of endothelial cell extracellular signal-regulated kinase1/2 in urokinase-type plasminogen activator upregulation and in vitro angiogenesis by fibroblast growth factor-2

1 reference

12 December 2020

Characterization and expression patterns of the MAPK family in zebrafish

1 reference

12 December 2020

Identifiers

DOI

10.1186/1471-213X-8-42

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18419805%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

5 January 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18419805%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

PubMed publication ID

18419805

1 reference