Fragment approaches in structure-based drug discovery (Q33329074)

25 July 2017

title

Fragment approaches in structure-based drug discovery (English)

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25 July 2017

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Roderick E Hubbard

1

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25 July 2017

publication date

18 April 2008

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Journal of Synchrotron Radiation

25 July 2017

published in

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25 July 2017

volume

15

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25 July 2017

issue

Pt 3

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25 July 2017

page(s)

227-230

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The SeeDs approach: integrating fragments into drug discovery

25 July 2017

cites work

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Informatics and modeling challenges in fragment-based drug discovery.

14 July 2018

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Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues

14 July 2018

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A decade of fragment-based drug design: strategic advances and lessons learned

14 July 2018

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14 July 2018

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In vivo role of the phosphate groove of PDK1 defined by knockin mutation

14 July 2018

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The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors

14 July 2018

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A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design

14 July 2018

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Identification of novel p38alpha MAP kinase inhibitors using fragment-based lead generation.

14 July 2018

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Design and characterization of libraries of molecular fragments for use in NMR screening against protein targets.

14 July 2018

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Fragment-based lead discovery

14 July 2018

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PDK1, the master regulator of AGC kinase signal transduction

14 July 2018

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Drug-like annotation and duplicate analysis of a 23-supplier chemical database totalling 2.7 million compounds

14 July 2018

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Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor

14 July 2018

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Experimental and computational mapping of the binding surface of a crystalline protein

14 July 2018

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Discovering novel ligands for macromolecules using X-ray crystallographic screening

14 July 2018

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Discovering high-affinity ligands for proteins: SAR by NMR

14 July 2018

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Discovery of a potent inhibitor of the antiapoptotic protein Bcl-xL from NMR and parallel synthesis

14 July 2018

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Fragment-Based Drug Discovery

31 October 2018

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Proteins in organic solvents

31 October 2018

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10.1107/S090904950705666X

31 October 2018

Identifiers

DOI

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25 July 2017

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25 July 2017

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