CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future (Q33337445)

25 July 2017

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title

CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future (English)

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25 July 2017

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1

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PubMed ID

12154405

25 July 2017

language of work or name

English

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publication date

1 August 2002

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25 July 2017

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25 July 2017

21

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25 July 2017

35

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25 July 2017

5427-5440

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1205600

25 July 2017

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cites work

Molecular Detection of Tumor Cells in Bronchoalveolar Lavage Fluid From Patients With Early Stage Lung Cancer

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Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer

21 January 2018

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Methylation-sensitive, single-strand conformation analysis (MS-SSCA): A rapid method to screen for and analyze methylation

21 January 2018

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CpG-rich islands and the function of DNA methylation

21 January 2018

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Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers.

21 January 2018

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Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

21 January 2018

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DNA hypomethylation leads to elevated mutation rates

21 January 2018

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High sensitivity mapping of methylated cytosines

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

Absence of methylation of CpG dinucleotides within the promoter of the breast cancer susceptibility gene BRCA2 in normal tissues and in breast and ovarian cancers

21 January 2018

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Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

The short arm of chromosome 11 is a "hot spot" for hypermethylation in human neoplasia

21 January 2018

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MethyLight: a high-throughput assay to measure DNA methylation

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas

21 January 2018

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Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

21 January 2018

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Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome

21 January 2018

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DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis

21 January 2018

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Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

Hypermethylation of the hMLH1 gene promoter is associated with microsatellite instability in early human gastric neoplasia.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

DNA methyltransferase Dnmt1 associates with histone deacetylase activity

21 January 2018

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Rapid quantitation of methylation differences at specific sites using methylation-sensitive single nucleotide primer extension (Ms-SNuPE)

21 January 2018

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Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions in de novo methylation.

21 January 2018

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Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma

21 January 2018

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Bisulfite genomic sequencing: systematic investigation of critical experimental parameters

21 January 2018

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Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

21 January 2018

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Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma

21 January 2018

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Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

21 January 2018

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The DNA methylation paradox

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

Cancer epigenetics comes of age

21 January 2018

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Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

21 January 2018

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Hypermethylated APC DNA in plasma and prognosis of patients with esophageal adenocarcinoma

21 January 2018

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DNA methylation affects the formation of active chromatin

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

Aberrant methylation and histone deacetylation of cyclooxygenase 2 in gastric cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

Methylation and silencing of the Thrombospondin-1 promoter in human cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

Promoter methylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G:C --> A:T mutations of the TP53 tumor suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

Susceptibility of nonpromoter CpG islands to de novo methylation in normal and neoplastic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

Altered chromatin structure associated with methylation-induced gene silencing in cancer cells: correlation of accessibility, methylation, MeCP2 binding and acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

The endothelin receptor B (EDNRB) promoter displays heterogeneous, site specific methylation patterns in normal and tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

Methylation of O(6)-methylguanine-DNA methyltransferase gene is associated significantly with K-ras mutation, lymph node invasion, tumor staging, and disease free survival in patients with gastric carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

Genomic imprinting, DNA methylation, and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

CpG methylation is maintained in human cancer cells lacking DNMT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

Transcriptional repression of BRCA1 by aberrant cytosine methylation, histone hypoacetylation and chromatin condensation of the BRCA1 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

Hypermethylation trigger of the glutathione-S-transferase gene (GSTP1) in prostate cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

Methylation-mediated silencing of TMS1/ASC is accompanied by histone hypoacetylation and CpG island-localized changes in chromatin architecture

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

Methylation and silencing of the retinoic acid receptor-beta2 gene in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

COBRA: a sensitive and quantitative DNA methylation assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

Overcoming cellular senescence in human cancer pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

Increased expression of unmethylated CDKN2D by 5-aza-2'-deoxycytidine in human lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

K-ras and p16 aberrations confer poor prognosis in human colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

Promoter Methylation and Silencing of the Retinoic Acid Receptor- Gene in Lung Carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer: correlation with disease characteristics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

7 January 2021

hMLH1 promoter hypermethylation is an early event in human endometrial tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

7 January 2021

Detection of breast cancer cells in ductal lavage fluid by methylation-specific PCR

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

7 January 2021

Gene-Expression Profiles in Hereditary Breast Cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

7 January 2021

Association of 5' CpG demethylation and altered chromatin structure in the promoter region with transcriptional activation of the multidrug resistance 1 gene in human cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

7 January 2021

Reactivation of an inactive human X chromosome: evidence for X inactivation by DNA methylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

7 January 2021

Quantitative DNA methylation analysis by fluorescent polymerase chain reaction single-strand conformation polymorphism using an automated DNA sequencer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

7 January 2021

Hypermethylation of the death-associated protein (DAP) kinase promoter and aggressiveness in stage I non-small-cell lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

7 January 2021

Continuous infusion of low-dose 5-Aza-2'-deoxycytidine in elderly patients with high-risk myelodysplastic syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

7 January 2021

SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205600

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205600

1 reference

PubMed ID

12154405

Dimensions Publication ID

25 July 2017

0 references

1 reference

PubMed ID

12154405