Structures of perfringolysin O suggest a pathway for activation of cholesterol-dependent cytolysins (Q33343788)

26 July 2017

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title

Structures of perfringolysin O suggest a pathway for activation of cholesterol-dependent cytolysins (English)

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26 July 2017

1

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26 July 2017

Craig J Morton

4

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Michael W Parker

object named as

Michael W Parker

6

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author name string

Galina Polekhina

2

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PubMed ID

17328912

26 July 2017

Susanne C Feil

3

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PubMed ID

17328912

26 July 2017

Rodney K Tweten

5

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26 July 2017

23 January 2007

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Journal of Molecular Biology

26 July 2017

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26 July 2017

367

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26 July 2017

1227-1236

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26 July 2017

5

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Optimal description of a protein structure in terms of multiple groups undergoing TLS motion

26 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674820

Inactivation and activity of cholesterol-dependent cytolysins: what structural studies tell us.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674820

The domains of a cholesterol-dependent cytolysin undergo a major FRET-detected rearrangement during pore formation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674820

Insights into the action of the superfamily of cholesterol-dependent cytolysins from studies of intermedilysin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674820

Vertical collapse of a cytolysin prepore moves its transmembrane beta-hairpins to the membrane

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674820

The solution structure and oligomerization behavior of two bacterial toxins: pneumolysin and perfringolysin O.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674820

Redefining cholesterol's role in the mechanism of the cholesterol-dependent cytolysins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674820

Structural insights into the membrane-anchoring mechanism of a cholesterol-dependent cytolysin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674820

The Listeria monocytogenes hemolysin has an acidic pH optimum to compartmentalize activity and prevent damage to infected host cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674820

Monomer-monomer interactions drive the prepore to pore conversion of a beta-barrel-forming cholesterol-dependent cytolysin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674820

Beta-barrel pore-forming toxins: intriguing dimorphic proteins

28 July 2018

1 reference

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The cholesterol-dependent cytolysins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674820

Mechanism of membrane insertion of a multimeric beta-barrel protein: perfringolysin O creates a pore using ordered and coupled conformational changes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674820

Arresting pore formation of a cholesterol-dependent cytolysin by disulfide trapping synchronizes the insertion of the transmembrane beta-sheet from a prepore intermediate

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674820

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674820

Structure of a cholesterol-binding, thiol-activated cytolysin and a model of its membrane form

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674820

Detecting and overcoming crystal twinning

28 July 2018

1 reference

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Membrane-penetrating domain of streptolysin O identified by cysteine scanning mutagenesis.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674820

Rendering a membrane protein soluble in water: a common packing motif in bacterial protein toxins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674820

Capacity of listeriolysin O, streptolysin O, and perfringolysin O to mediate growth of Bacillus subtilis within mammalian cells

28 July 2018

1 reference

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Structural basis of pore formation by the bacterial toxin pneumolysin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674820

Two structural transitions in membrane pore formation by pneumolysin, the pore-forming toxin of Streptococcus pneumoniae.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674820

Contribution of individual tryptophan residues to the structure and activity of theta-toxin (perfringolysin O), a cholesterol-binding cytolysin.

31 October 2018

1 reference

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Modeling the bacterial protein toxin, pneumolysin, in its monomeric and oligomeric form

31 October 2018

1 reference

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The crystal structure of diphtheria toxin

31 October 2018

1 reference

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Self-interaction of pneumolysin, the pore-forming protein toxin of Streptococcus pneumoniae

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674820

Identification of a Membrane-Spanning Domain of the Thiol-Activated Pore-Forming ToxinClostridium perfringensPerfringolysin O: An α-Helical to β-Sheet Transition Identified by Fluorescence Spectroscopy†

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674820

The Mechanism of Membrane Insertion for a Cholesterol-Dependent Cytolysin

10 December 2018

1 reference

12 December 2020

Streptolysin O: inhibition of the conformational change during membrane binding of the monomer prevents oligomerization and pore formation

1 reference

12 December 2020

The mechanism of pore assembly for a cholesterol-dependent cytolysin: formation of a large prepore complex precedes the insertion of the transmembrane beta-hairpins

1 reference

12 December 2020

A 'molten-globule' membrane-insertion intermediate of the pore-forming domain of colicin A

1 reference

12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

1 reference

12 December 2020

On the calculation of pKas in proteins

1 reference

12 December 2020

Interaction of theta-toxin (perfringolysin O), a cholesterol-binding cytolysin, with liposomal membranes: change in the aromatic side chains upon binding and insertion

1 reference

12 December 2020

Crystallization and preliminary X-ray analysis of a thiol-activated cytolysin

1 reference

12 December 2020

Streptolysin O: a proposed model of allosteric interaction between a pore-forming protein and its target lipid bilayer

1 reference

12 December 2020

10.1016/J.JMB.2007.01.042

Identifiers

DOI

1 reference

26 July 2017

1 reference

26 July 2017

1 reference

PubMed ID

17328912