PEGylated helper-dependent adenoviral vectors: highly efficient vectors with an enhanced safety profile (Q33364520)

26 July 2017

PEGylated helper-dependent adenoviral vectors: highly efficient vectors with an enhanced safety profile (English)

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26 July 2017

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L Pastore

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Gabriele Toietta

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G Toietta

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Vincenzo Cerullo

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V Cerullo

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Maria A Croyle

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M A Croyle

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26 July 2017

H T Le

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PubMed ID

15647765

26 July 2017

K D Linse

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PubMed ID

15647765

26 July 2017

A Beaudet

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26 July 2017

1 April 2005

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579-587

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https://scigraph.springernature.com/pub.10.1038/sj.gt.3302441

26 July 2017

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Gene transfer into the liver of nonhuman primates with E1-deleted recombinant adenoviral vectors: safety of readministration

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Modulation of the inflammatory properties and hepatotoxicity of recombinant adenovirus vectors by the viral E4 gene products.

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Lethal toxicity, severe endothelial injury, and a threshold effect with high doses of an adenoviral vector in baboons

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Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo

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Acute cytokine response to systemic adenoviral vectors in mice is mediated by dendritic cells and macrophages

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Molecular basis of the inflammatory response to adenovirus vectors

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Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer

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Activation of innate immunity in nonhuman primates following intraportal administration of adenoviral vectors.

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High doses of a helper-dependent adenoviral vector yield supraphysiological levels of alpha1-antitrypsin with negligible toxicity

21 January 2018

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Lifetime correction of genetic deficiency in mice with a single injection of helper-dependent adenoviral vector

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Long-term stable correction of low-density lipoprotein receptor-deficient mice with a helper-dependent adenoviral vector expressing the very low-density lipoprotein receptor

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Selective depletion or blockade of Kupffer cells leads to enhanced and prolonged hepatic transgene expression using high-capacity adenoviral vectors

21 January 2018

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Acute toxicity after high-dose systemic injection of helper-dependent adenoviral vectors into nonhuman primates.

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Helper-dependent adenovirus vectors elicit intact innate but attenuated adaptive host immune responses in vivo

21 January 2018

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Use of helper-dependent adenoviral vectors of alternative serotypes permits repeat vector administration

21 January 2018

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PEGylation of E1-deleted adenovirus vectors allows significant gene expression on readministration to liver

21 January 2018

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The role of capsid-endothelial interactions in the innate immune response to adenovirus vectors

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Effect of pegylation on pharmaceuticals

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Endogenous mediators in emergency department patients with presumed sepsis: are levels associated with progression to severe sepsis and death?

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Intravenous administration of replication-incompetent adenovirus to rhesus monkeys induces thrombocytopenia by increasing in vivo platelet clearance

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Prolonged transgene expression mediated by a helper-dependent adenoviral vector (hdAd) in the central nervous system

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Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity.

21 January 2018

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A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal

21 January 2018

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PEGylation of adenovirus with retention of infectivity and protection from neutralizing antibody in vitro and in vivo.

21 January 2018

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Use of a liver-specific promoter reduces immune response to the transgene in adenoviral vectors

21 January 2018

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7 January 2021

Cytotoxic T-lymphocyte target proteins and their major histocompatibility complex class I restriction in response to adenovirus vectors delivered to mouse liver.

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7 January 2021

Toxicity associated with repeated administration of first-generation adenovirus vectors does not occur with a helper-dependent vector.

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7 January 2021

A method for the estimation of polyethylene glycol in plasma protein fractions

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7 January 2021

Immune tolerance induced by polyethylene glycol-conjugate of protein antigen: clonal deletion of antigen-specific Th-cells in the thymus

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7 January 2021

Extended blood half-life of monomethoxypolyethylene glycol-conjugated hen lysozyme is a key parameter controlling immunological tolerogenicity

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7 January 2021

Helper-dependent adenoviral vectors

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7 January 2021

The polypeptides of adenovirus. I. Evidence for multiple protein components in the virion and a comparison of types 2, 7A, and 12

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7 January 2021

Identifiers

DOI

10.1038/SJ.GT.3302441

1 reference

26 July 2017

1 reference

PubMed ID

15647765