IL-21 limits peripheral lymphocyte numbers through T cell homeostatic mechanisms (Q33367125)

26 July 2017

IL-21 limits peripheral lymphocyte numbers through T cell homeostatic mechanisms (English)

1 reference

26 July 2017

Shrimati Datta

1

1 reference

PubMed ID

18773086

26 July 2017

Nora E Sarvetnick

series ordinal

2

1 reference

PubMed ID

18773086

26 July 2017

language of work or name

English

0 references

publication date

5 September 2008

1 reference

26 July 2017

1 reference

26 July 2017

3

1 reference

26 July 2017

e3118

1 reference

26 July 2017

9

1 reference

Creative Commons Attribution 4.0 International

26 July 2017

start time

5 September 2008

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages

21 June 2018

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Interleukin 21 enhances antibody-mediated tumor rejection

21 June 2018

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B cell depletion: a novel therapy for autoimmune diabetes?

21 June 2018

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21 June 2018

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IL-21 synergizes with IL-7 to augment expansion and anti-tumor function of cytotoxic T cells

21 June 2018

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Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

21 June 2018

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IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells

21 June 2018

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IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

21 June 2018

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IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production

21 June 2018

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Interleukin-21 induces T-cell activation and proinflammatory cytokine secretion in rheumatoid arthritis

21 June 2018

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Autoimmunity during lymphopenia: a two-hit model

21 June 2018

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Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation

21 June 2018

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Pathogenic T-cell clones in autoimmune diabetes: more lessons from the NOD mouse

21 June 2018

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IL-21 influences the frequency, phenotype, and affinity of the antigen-specific CD8 T cell response

21 June 2018

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Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition

21 June 2018

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A causal link between lymphopenia and autoimmunity

21 June 2018

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Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function.

21 June 2018

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The new paradigm of T-cell homeostatic proliferation-induced autoimmunity

21 June 2018

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Lymphopenia and autoimmune diseases

21 June 2018

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Interleukin-7 inactivates the pro-apoptotic protein Bad promoting T cell survival

21 June 2018

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Homeostatic expansion of T cells during immune insufficiency generates autoimmunity.

21 June 2018

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A critical role for IL-21 in regulating immunoglobulin production

21 June 2018

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Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells

21 June 2018

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IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response

21 June 2018

1 reference

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Maintaining the norm: T-cell homeostasis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527999

The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3

21 June 2018

2 references

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21 June 2018

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003118

Cytokine requirements for acute and Basal homeostatic proliferation of naive and memory CD8+ T cells

21 January 2018

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Different contributions of thymopoiesis and homeostasis-driven proliferation to the reconstitution of naive and memory T cell compartments

21 June 2018

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Interleukin-7 and interleukin-15 regulate the expression of the bcl-2 and c-myb genes in cutaneous T-cell lymphoma cells.

21 June 2018

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T cell homeostasis and systemic autoimmunity

21 June 2018

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Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex

21 June 2018

1 reference

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Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

21 June 2018

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Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation

21 June 2018

1 reference

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Role of inflammatory infiltrate in activation and effector function of cloned islet reactive nonobese diabetic CD8+ T cells: involvement of a nitric oxide-dependent pathway.

21 June 2018

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Interleukin-10 promotes activation-induced cell death of SLE lymphocytes mediated by Fas ligand

21 June 2018

1 reference

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Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice

21 June 2018

1 reference

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Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527999

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527999

Loss of pancreatic islet tolerance induced by beta-cell expression of interferon-gamma

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527999

Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis.

21 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003118

IL-21 induces apoptosis of antigen-specific CD8+ T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003118

Opposing actions of STAT-1 and STAT-3 on the Bcl-2 and Bcl-x promoters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003118

IL-21 sustains CD28 expression on IL-15-activated human naive CD8+ T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003118

Characterization of the ovalbumin-specific TCR transgenic line OT-I: MHC elements for positive and negative selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003118

B7-2 (CD86) controls the priming of autoreactive CD4 T cell response against pancreatic islets

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527999

Spontaneous formation of germinal centers in autoimmune mice.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527999

B lymphocytes are crucial antigen-presenting cells in the pathogenic autoimmune response to GAD65 antigen in nonobese diabetic mice.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527999

Differential effects of IL-21 during initiation and progression of autoimmunity against neuroantigen

31 October 2018

1 reference

12 December 2020

Effector function of diabetogenic CD4 Th1 T cell clones: a central role for TNF-alpha

1 reference

12 December 2020

Homeostatic proliferation as an isolated variable reverses CD8+ T cell anergy and promotes tumor rejection

1 reference

12 December 2020

IL-21 Counteracts the Regulatory T Cell-Mediated Suppression of Human CD4+ T Lymphocytes

1 reference

12 December 2020

Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis

1 reference

12 December 2020

IL-21 promotes T lymphocyte survival by activating the phosphatidylinositol-3 kinase signaling cascade

1 reference

12 December 2020

Interferon-gamma receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD mice

1 reference

12 December 2020

Thymic function and peripheral T-cell homeostasis in rheumatoid arthritis

1 reference

12 December 2020

T lymphocytes need IL-7 but not IL-4 or IL-6 to survive in vivo

1 reference

12 December 2020

IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity

1 reference

12 December 2020

Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis

1 reference

12 December 2020

T-cell compartments of prediabetic NOD mice

1 reference

12 December 2020

Overexpression of bcl-2 in T cells affects insulitis in the nonobese diabetic mouse

1 reference

12 December 2020

IL-21 induces the apoptosis of resting and activated primary B cells

1 reference

12 December 2020

Low bcl-2 expression and increased spontaneous apoptosis in T-lymphocytes from newly-diagnosed IDDM patients

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0003118

Identifiers

DOI

1 reference

26 July 2017

0 references

1 reference

26 July 2017

1 reference

PubMed ID

18773086