Genetic analysis of the role of protein kinase Ctheta in platelet function and thrombus formation (Q33371697)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18815612%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

title

Genetic analysis of the role of protein kinase Ctheta in platelet function and thrombus formation (English)

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14 January 2020

2

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14 January 2020

Alastair W Poole

6

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14 January 2020

Johan W.M. Heemskerk

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ORCID Public Data File 2021

Karen Gilio

3

object named as

Karen Gilio

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14 January 2020

Judith M E M Cosemans

4

object named as

Judith M Cosemans

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14 January 2020

author name string

Kellie J Hall

1

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14 January 2020

Johan W M Heemskerk

5

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14 January 2020

language of work or name

English

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publication date

25 September 2008

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14 January 2020

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14 January 2020

volume

3

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issue

9

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14 January 2020

page(s)

e3277

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Creative Commons Attribution 4.0 International

14 January 2020

copyright license

start time

25 September 2008

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Structure-based optimization of PKCtheta inhibitors

1 reference

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Isoform-specific functions of protein kinase C: the platelet paradigm.

21 June 2018

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The impact of blood rheology on the molecular and cellular events underlying arterial thrombosis.

21 June 2018

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PKCdelta regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation

21 June 2018

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Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase C theta-deficient mice

21 June 2018

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Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow.

21 June 2018

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Regulation of outside-in signaling in platelets by integrin-associated protein kinase C beta

21 June 2018

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PKC-theta knockout mice are protected from fat-induced insulin resistance

21 June 2018

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Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells

21 June 2018

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Direct Demonstration of Involvement of Protein Kinase Cα in the Ca2+-induced Platelet Aggregation

21 June 2018

1 reference

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Physical and functional interaction between protein kinase C delta and Fyn tyrosine kinase in human platelets

21 June 2018

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Kinase inhibitors: not just for kinases anymore

21 June 2018

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Interaction of Bruton's tyrosine kinase and protein kinase Ctheta in platelets. Cross-talk between tyrosine and serine/threonine kinases

21 June 2018

1 reference

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Rottlerin is a mitochondrial uncoupler that decreases cellular ATP levels and indirectly blocks protein kinase Cdelta tyrosine phosphorylation

21 June 2018

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Specificity and mechanism of action of some commonly used protein kinase inhibitors

21 June 2018

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Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival.

21 June 2018

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Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells

21 June 2018

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Molecular cloning and expression of a cDNA encoding a novel isoenzyme of protein kinase C (nPKC). A new member of the nPKC family expressed in skeletal muscle, megakaryoblastic cells, and platelets

21 June 2018

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Identification and functional characterization of protein kinase C isozymes in platelets and HEL cells

21 June 2018

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Differential Role of Protein Kinase Cδ Isoform in Agonist-induced Dense Granule Secretion in Human Platelets

21 June 2018

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Identification of protein kinase Calpha as an essential, but not sufficient, cytosolic factor for Ca2+-induced alpha- and dense-core granule secretion in platelets

21 January 2018

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PKC-theta-deficient mice are protected from Th1-dependent antigen-induced arthritis.

21 January 2018

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The role of stem cells in vein graft remodelling

21 January 2018

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A role for PKCtheta in outside-in alpha(IIb)beta3 signaling.

21 January 2018

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Complementary roles of glycoprotein VI and alpha2beta1 integrin in collagen-induced thrombus formation in flowing whole blood ex vivo

21 January 2018

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A New Protein Kinase C, nPKCη′, and nPCKθ Are Expressed in Human Platelets: Involvement of nPKCη′ and nPKCθ in Signal Transduction Stimulated by PAF

31 October 2018

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PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

21 January 2018

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Different translocation of three distinct PKC isoforms with tumor-promoting phorbol ester in human platelets

21 January 2018

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12 December 2020

Translocation of protein kinase C isozymes in thrombin-stimulated human platelets. Correlation with 1,2-diacylglycerol levels

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12 December 2020

Mice deficient in PKC theta demonstrate impaired in vivo T cell activation and protection from T cell-mediated inflammatory diseases

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12 December 2020

Distinct but critical roles for integrin ?IIb?3in platelet lamellipodia formation on fibrinogen, collagen-related peptide and thrombin

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12 December 2020

Discovery of potent and selective PKC-theta inhibitors

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12 December 2020

Dual role of platelet protein kinase C in thrombus formation: stimulation of pro-aggregatory and suppression of procoagulant activity in platelets

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12 December 2020

10.1371/JOURNAL.PONE.0003277

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14 January 2020

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14 January 2020

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