Revisiting the design of phase III clinical trials of antimalarial drugs for uncomplicated Plasmodium falciparum malaria (Q33385477)

26 July 2017

Revisiting the design of phase III clinical trials of antimalarial drugs for uncomplicated Plasmodium falciparum malaria (English)

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Plasmodium falciparum malaria

26 July 2017

phase III clinical trial

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Plasmodium falciparum

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antimalarial

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malaria

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1 reference

1

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26 July 2017

3

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26 July 2017

5

Nicholas J White

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26 July 2017

2

Tim Peto

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26 July 2017

Win Gutteridge

4

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PubMed ID

19018658

26 July 2017

language of work or name

English

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publication date

1 November 2008

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26 July 2017

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26 July 2017

5

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26 July 2017

11

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26 July 2017

e227

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Creative Commons Attribution 4.0 International

26 July 2017

start time

18 November 2008

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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1 reference

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Risk associated with asymptomatic parasitaemia occurring post-antimalarial treatment

21 June 2018

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Antimalarial dosing regimens and drug resistance

21 June 2018

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How antimalarial drug resistance affects post-treatment prophylaxis

21 June 2018

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Monitoring and deterring drug-resistant malaria in the era of combination therapy

21 June 2018

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Impact of artemisinin-based combination therapy and insecticide-treated nets on malaria burden in Zanzibar

21 June 2018

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Clinical and pharmacological determinants of the therapeutic response to dihydroartemisinin-piperaquine for drug-resistant malaria

21 June 2018

1 reference

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World Antimalarial Resistance Network I: clinical efficacy of antimalarial drugs

21 June 2018

1 reference

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Efficacy studies of malaria treatments in Africa: efficient estimation with missing indicators of failure

21 June 2018

1 reference

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Impact of transmission intensity on the accuracy of genotyping to distinguish recrudescence from new infection in antimalarial clinical trials

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586344

Safety and clinical outcome of experimental challenge of human volunteers with Plasmodium falciparum-infected mosquitoes: an update

21 June 2018

1 reference

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The challenges of changing national malaria drug policy to artemisinin-based combinations in Kenya

21 June 2018

1 reference

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Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment of malaria: a randomized trial

21 June 2018

1 reference

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Two fixed-dose artemisinin combinations for drug-resistant falciparum and vivax malaria in Papua, Indonesia: an open-label randomised comparison

21 June 2018

1 reference

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Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites

21 June 2018

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Artemether-lumefantrine versus amodiaquine plus sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Burkina Faso: a randomised non-inferiority trial

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586344

Some considerations in the design and interpretation of antimalarial drug trials in uncomplicated falciparum malaria

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586344

The use of genotyping in antimalarial clinical trials: a systematic review of published studies from 1995-2005

21 June 2018

1 reference

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Intrahost selection of Plasmodium falciparum pfmdr1 alleles after antimalarial treatment on the northwestern border of Thailand

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586344

Innovative lead discovery strategies for tropical diseases

21 June 2018

1 reference

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Methodological issues in the assessment of antimalarial drug treatment: analysis of 13 studies in eight African countries from 2001 to 2004.

21 June 2018

1 reference

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Medicines for Malaria Venture: sustaining antimalarial drug development

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586344

Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malaria

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586344

Complexity of Plasmodium falciparum infections and antimalarial drug efficacy at 7 sites in Uganda

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586344

Reporting of noninferiority and equivalence randomized trials: an extension of the CONSORT statement

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586344

Pitfalls in estimating piperaquine elimination

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586344

Distinguishing recrudescences from new infections in antimalarial clinical trials: major impact of interpretation of genotyping results on estimates of drug efficacy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586344

Artemisinin-based combination therapies (ACTs): best hope for malaria treatment but inaccessible to the needy!

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586344

Supervised versus unsupervised intake of six-dose artemether-lumefantrine for treatment of acute, uncomplicated Plasmodium falciparum malaria in Mbarara, Uganda: a randomised trial

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586344

The global distribution of clinical episodes of Plasmodium falciparum malaria

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586344

Combination treatments for uncomplicated falciparum malaria in Kampala, Uganda: randomised clinical trial

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586344

In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586344

A systematic overview of published antimalarial drug trials

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586344

Clearance of drug-resistant parasites as a model for protective immunity in Plasmodium falciparum malaria.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586344

Estimating the needs for artesunate-based combination therapy for malaria case-management in Africa

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586344

The consequences of reducing transmission of Plasmodium falciparum in Africa

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586344

Generation of allocation sequences in randomised trials: chance, not choice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586344

The past, present and future of childhood malaria mortality in Africa

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586344

Amodiaquine, sulfadoxine/pyrimethamine, and combination therapy for treatment of uncomplicated falciparum malaria in Kampala, Uganda: a randomised trial

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586344

Assessment of the pharmacodynamic properties of antimalarial drugs in vivo

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586344

Trials to assess equivalence: the importance of rigorous methods

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586344

Attributable fraction estimates and case definitions for malaria in endemic areas

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586344

Indicators of life-threatening malaria in African children

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586344

Can estimates of antimalarial efficacy from field studies be improved?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586344

Design and analysis of non-inferiority mortality trials in oncology.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586344

Genotyping of Plasmodium falciparum infections by PCR: a comparative multicentre study

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586344

10.1371/JOURNAL.PMED.0050227

31 October 2018

Identifiers

DOI

1 reference

26 July 2017

1 reference

26 July 2017

1 reference

PubMed ID

19018658