Direct thrombin inhibitors: pharmacology and application in intensive care medicine (Q33389326)

26 July 2017

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title

Direct thrombin inhibitors: pharmacology and application in intensive care medicine (English)

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26 July 2017

Eva Schaden

1

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26 July 2017

Sibylle A Kozek-Langenecker

series ordinal

2

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26 July 2017

publication date

28 April 2010

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26 July 2017

published in

Intensive Care Medicine

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26 July 2017

volume

36

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26 July 2017

issue

7

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26 July 2017

page(s)

1127-1137

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Platelet activation with unfractionated heparin at therapeutic concentrations and comparisons with a low-molecular-weight heparin and with a direct thrombin inhibitor

26 July 2017

cites work

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00134-010-1888-3

Lepirudin (recombinant hirudin) for parenteral anticoagulation in patients with heparin-induced thrombocytopenia. Heparin-Associated Thrombocytopenia Study (HAT) investigators.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00134-010-1888-3

Argatroban anticoagulant therapy in patients with heparin-induced thrombocytopenia.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00134-010-1888-3

Argatroban anticoagulation in patients with heparin-induced thrombocytopenia

21 January 2018

1 reference

12 December 2020

The structure of a complex of recombinant hirudin and human alpha-thrombin

1 reference

12 December 2020

Argatroban therapy does not generate antibodies that alter its anticoagulant activity in patients with heparin-induced thrombocytopenia

1 reference

12 December 2020

Reversal of hirudin-induced bleeding diathesis by prothrombin complex concentrate

1 reference

12 December 2020

Ecarin chromogenic assay--a new method for quantitative determination of direct thrombin inhibitors like hirudin

1 reference

12 December 2020

Effects of argatroban as an anticoagulant for haemodialysis in patients with antithrombin III deficiency

1 reference

12 December 2020

Some objective considerations for the neutralization of the anticoagulant actions of recombinant hirudin

1 reference

12 December 2020

Antihirudin antibodies in patients with heparin-induced thrombocytopenia treated with lepirudin: incidence, effects on aPTT, and clinical relevance

1 reference

12 December 2020

Immune heparin-induced thrombocytopenia resulting from preceding exposure to heparin catheter flushes

1 reference

12 December 2020

Argatroban and renal replacement therapy in patients with heparin-induced thrombocytopenia

1 reference

12 December 2020

Design and characterization of hirulogs: a novel class of bivalent peptide inhibitors of thrombin

1 reference

12 December 2020

An evaluation of monitoring possibilities of argatroban using rotational thromboelastometry and activated partial thromboplastin time

1 reference

12 December 2020

Argatroban anticoagulation for renal replacement therapy in patients with heparin-induced thrombocytopenia after cardiovascular surgery

1 reference

12 December 2020

Effects of the synthetic thrombin inhibitor argatroban on fibrin- or clot-incorporated thrombin: comparison with heparin and recombinant Hirudin

1 reference

12 December 2020

Combined administration of aspirin and a specific thrombin inhibitor in man

1 reference

12 December 2020

Successful recovery after an overdose of argatroban

1 reference

12 December 2020

Heparin-induced thrombocytopenia in intensive care patients

1 reference

12 December 2020

Use of bivalirudin, a direct thrombin inhibitor, and its reversal with modified ultrafiltration during heart transplantation in a patient with heparin-induced thrombocytopenia

1 reference

12 December 2020

Evaluation of bivalirudin treatment for heparin-induced thrombocytopenia in critically ill patients with hepatic and/or renal dysfunction

1 reference

12 December 2020

Argatroban anticoagulation in critically ill patients

1 reference

12 December 2020

The mechanism of action of thrombin inhibitors

1 reference

12 December 2020

Activation of the tissue factor pathway occurs during continuous venovenous hemofiltration

1 reference

12 December 2020

Direct thrombin inhibitors in acute coronary syndromes: effect in patients undergoing early percutaneous coronary intervention

1 reference

12 December 2020

Monitoring of anticoagulant effects of direct thrombin inhibitors

1 reference

12 December 2020

Monitoring direct thrombin inhibitors: time for standardization

1 reference

12 December 2020

Treatment and prevention of heparin-induced thrombocytopenia: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).

1 reference

12 December 2020

Sera from patients with heparin-induced thrombocytopenia generate platelet-derived microparticles with procoagulant activity: an explanation for the thrombotic complications of heparin-induced thrombocytopenia.

1 reference

12 December 2020

Factor VIII and DDAVP reverse the effect of recombinant desulphatohirudin (CGP 39393) on bleeding in the rat

1 reference

12 December 2020

Lepirudin in patients with heparin-induced thrombocytopenia - results of the third prospective study (HAT-3) and a combined analysis of HAT-1, HAT-2, and HAT-3

1 reference

12 December 2020

Recombinant hirudin (lepirudin) as anticoagulant in intensive care patients treated with continuous hemodialysis.

1 reference

12 December 2020

Anticoagulation options for patients with heparin-induced thrombocytopenia requiring renal support in the intensive care unit

1 reference

12 December 2020

Tracheobronchial injuries and fistulas

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12 December 2020

Use of lepirudin in patients with heparin-induced thrombocytopenia and renal failure requiring hemodialysis

1 reference

12 December 2020

Kinetic mechanism for the interaction of Hirulog with thrombin.

1 reference

12 December 2020

Direct thrombin inhibitors in acute coronary syndromes: principal results of a meta-analysis based on individual patients' data

1 reference

12 December 2020

Heparin-induced thrombocytopenia with thromboembolic complications: meta-analysis of 2 prospective trials to assess the value of parenteral treatment with lepirudin and its therapeutic aPTT range.

1 reference

12 December 2020

Argatroban in extracorporeal membrane oxygenation

1 reference

12 December 2020

Diagnosis and treatment of heparin-induced thrombocytopenia in neonates and children

1 reference

12 December 2020

Severe anaphylactic reaction after repeated intermittent exposure to lepirudin

1 reference

12 December 2020

Bivalirudin provides increasing benefit with decreasing renal function: a meta-analysis of randomized trials

1 reference

12 December 2020

Argatroban dosing in intensive care patients with acute renal failure and liver dysfunction

1 reference

12 December 2020

Argatroban anticoagulation in patients with heparin-induced thrombocytopenia requiring renal replacement therapy

1 reference

12 December 2020

Thrombin-activated thrombelastography for evaluation of thrombin interaction with thrombin inhibitors

1 reference

12 December 2020

Effect of a 15-minute infusion of DDAVP on the pharmacokinetics and pharmacodynamics of REVASC during a four-hour intravenous infusion in healthy male volunteers

1 reference

12 December 2020

Frequency of heparin-induced thrombocytopenia in critical care patients

1 reference

12 December 2020

Safety, efficacy, and dosing requirements of bivalirudin in patients with heparin-induced thrombocytopenia

1 reference

12 December 2020

Low plasma fibrinogen levels with the Clauss method during anticoagulation with bivalirudin

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12 December 2020

Point-of-care ecarin clotting time versus activated clotting time in correlation with bivalirudin concentration

1 reference

12 December 2020

Direct thrombin inhibition during percutaneous coronary intervention in patients with heparin-induced thrombocytopenia

1 reference

12 December 2020

Comparative anticoagulant effects of various thrombin inhibitors, as determined in the ecarin clotting time method

1 reference

12 December 2020

An Assessment of Different Filter Systems for Extracorporeal Elimination of Bivalirudin: An In Vitro Study

1 reference

12 December 2020

Investigation of activated prothrombin complex concentrate as potential hirudin antidote in animal models

1 reference

12 December 2020

DDAVP reduces bleeding during continued hirudin administration in the rabbit

1 reference

12 December 2020

Correlation of Point-of-Care ecarin clotting time versus activated clotting time with bivalirudin concentrations

1 reference

12 December 2020

Bivalirudin pharmacokinetics and pharmacodynamics: effect of renal function, dose, and gender

1 reference

12 December 2020

Alternative parenteral anticoagulation with argatroban, a direct thrombin inhibitor

1 reference

12 December 2020

Recombinant activated factor VII effectively reverses the anticoagulant effects of heparin, enoxaparin, fondaparinux, argatroban, and bivalirudin ex vivo as measured using thromboelastography

1 reference

12 December 2020

A prospective comparison of three argatroban treatment regimens during hemodialysis in end-stage renal disease

1 reference

12 December 2020

Ecarin clotting time but not aPTT correlates with PEG-hirudin plasma activity

1 reference

12 December 2020

Lokoregionalanästhesien unter gerinnungshemmender Medikation

1 reference

12 December 2020

Anaphylactic and anaphylactoid reactions associated with lepirudin in patients with heparin-induced thrombocytopenia.

1 reference

12 December 2020

The influence of infusions of 1-desamino-8-D-arginine vasopressin (DDAVP) in vivo on the anticoagulant effect of recombinant hirudin (CGP39393) in vitro

1 reference

12 December 2020

Continuous venovenous haemofiltration using polyacrylonitrile filters does not activate contact system and intrinsic coagulation pathways

1 reference

12 December 2020

Successful treatment of heparin-associated thrombocytopenia and thrombosis using Hirulog.

1 reference

12 December 2020

Pharmacokinetics of recombinant hirudin in hemodialyzed end-stage renal failure patients.

1 reference

12 December 2020

Transition from argatroban to oral anticoagulation with phenprocoumon or acenocoumarol: effects on prothrombin time, activated partial thromboplastin time, and Ecarin Clotting Time.

1 reference

12 December 2020

The pharmacokinetics and pharmacodynamics of argatroban: effects of age, gender, and hepatic or renal dysfunction

1 reference

12 December 2020

Effect of acute renal failure requiring renal replacement therapy on outcome in critically ill patients

1 reference

12 December 2020

Differences in the clinically effective molar concentrations of four direct thrombin inhibitors explain their variable prothrombin time prolongation

1 reference

12 December 2020

Synthetic inhibitors of thrombin and factor Xa: from bench to bedside

1 reference

12 December 2020

A case review: anticoagulation in hemodialysis patients with heparin-induced thrombocytopenia

1 reference

12 December 2020

Prothrombin conversion intermediate effectively neutralizes toxic levels of hirudin

1 reference

12 December 2020

Lepirudin: is the approved dosing schedule too high?

1 reference

12 December 2020

Hirudin determination in plasma can be strongly influenced by the prothrombin level

1 reference

12 December 2020

Effect of argatroban on the activated partial thromboplastin time: a comparison of 21 commercial reagents

1 reference

12 December 2020

Pharmacology, pharmacokinetics, and pharmacodynamics of dabigatran etexilate, an oral direct thrombin inhibitor

1 reference

12 December 2020

Lepirudin: a bivalent direct thrombin inhibitor for anticoagulation therapy

1 reference

12 December 2020

The use of lepirudin in haemodialysis complicated with heparin-induced thrombocytopenia type II (HIT II)--dosage monitoring

1 reference

12 December 2020

Lepirudin for prophylaxis of thrombosis in patients with acute isolated heparin-induced thrombocytopenia: an analysis of 3 prospective studies

1 reference

12 December 2020

Effects of ximelagatran, an oral direct thrombin inhibitor, r-hirudin and enoxaparin on thrombin generation and platelet activation in healthy male subjects.

1 reference

12 December 2020

Frequent development of lupus anticoagulants in critically ill patients treated under intensive care conditions

1 reference

12 December 2020

Argatroban for anticoagulation during cardiopulmonary bypass in an infant

1 reference

12 December 2020

Incidence and prognostic significance of thrombocytopenia in patients treated with prolonged heparin therapy

1 reference

12 December 2020

Pharmacology of heparins and direct anticoagulants

1 reference

12 December 2020

A novel approach to thrombin inhibition

1 reference

12 December 2020

The effects of heparin, protamine, and heparinase 1 on platelets in vitro using whole blood flow cytometry

1 reference

12 December 2020

Heparin-induced thrombocytopenia in patients administered heparin solely for hemodialysis

1 reference

12 December 2020

10.1007/S00134-010-1888-3

Identifiers

DOI

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26 July 2017

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