First-in-man phase I trial of two schedules of the novel synthetic tetrahydroisoquinoline alkaloid PM00104 (Zalypsis) in patients with advanced solid tumours (Q33400678)

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English	First-in-man phase I trial of two schedules of the novel synthetic tetrahydroisoquinoline alkaloid PM00104 (Zalypsis) in patients with advanced solid tumours	scientific article

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scholarly article

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28 January 2020

First-in-man phase I trial of two schedules of the novel synthetic tetrahydroisoquinoline alkaloid PM00104 (Zalypsis) in patients with advanced solid tumours (English)

1 reference

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28 January 2020

phase I clinical trial

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12

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28 January 2020

Josep Tabernero Caturla

16

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28 January 2020

Jose A. Lopez-Martin

19

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28 January 2020

author name string

T A Yap

1

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28 January 2020

H Cortes-Funes

2

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28 January 2020

H Shaw

3

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28 January 2020

R Rodriguez

4

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28 January 2020

D Olmos

5

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28 January 2020

R Lal

6

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28 January 2020

P C Fong

7

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28 January 2020

D S Tan

8

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28 January 2020

D Harris

9

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28 January 2020

J Capdevila

10

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28 January 2020

C Coronado

11

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28 January 2020

A Soto-Matos

13

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28 January 2020

C Fernández-Teruel

14

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28 January 2020

M Siguero

15

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28 January 2020

L Paz-Ares

17

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28 January 2020

J S de Bono

18

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28 January 2020

language of work or name

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publication date

1 April 2012

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28 January 2020

British Journal of Cancer

1 reference

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28 January 2020

106

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28 January 2020

8

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28 January 2020

1379-1385

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28 January 2020

https://scigraph.springernature.com/pub.10.1038/bjc.2012.99

0 references

Population pharmacokinetics of PM00104 (Zalypsis(®)) in cancer patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3326684

21 June 2018

Molecular pharmacology and antitumor activity of Zalypsis in several human cancer cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3326684

21 June 2018

American Society of Clinical Oncology guideline for antiemetics in oncology: update 2006.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3326684

21 June 2018

New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3326684

21 June 2018

Zalypsis (PM00104) is a potent inducer of gamma-H2AX foci and reveals the importance of the C ring of trabectedin for transcription-coupled repair inhibition.

1 reference

https://api.crossref.org/works/10.1038%2FBJC.2012.99

21 January 2018

Zalypsis: a novel marine-derived compound with potent antimyeloma activity that reveals high sensitivity of malignant plasma cells to DNA double-strand breaks.

1 reference

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21 January 2018

Renieramycin J, a highly cytotoxic tetrahydroisoquinoline alkaloid, from a marine sponge Neopetrosia sp..

1 reference

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21 January 2018

Potent activity of a novel dimeric heat shock protein 90 inhibitor against head and neck squamous cell carcinoma in vitro and in vivo.

1 reference

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21 January 2018

Development of a liquid chromatography/tandem mass spectrometry assay for the quantification of PM00104, a novel antineoplastic agent, in mouse, rat, dog, and human plasma.

1 reference

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21 January 2018

A New Antitumor Isoquinoline Alkaloid from the Marine Nudibranch Jorunna funebris

1 reference

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7 January 2021

based on heuristic

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Ecteinascidins 729, 743, 745, 759A, 759B, and 770: potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata

1 reference

https://api.crossref.org/works/10.1038%2FBJC.2012.99

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/BJC.2012.99

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28 January 2020

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28 January 2020

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28 January 2020

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