Diabetic retinopathy: current management and experimental therapeutic targets. (Q33403016)

26 July 2017

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title

Diabetic retinopathy: current management and experimental therapeutic targets. (English)

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26 July 2017

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Azza B El-Remessy

2

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author name string

Tayyeba K Ali

series ordinal

1

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26 July 2017

language of work or name

English

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publication date

1 February 2009

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26 July 2017

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26 July 2017

volume

29

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26 July 2017

issue

2

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26 July 2017

page(s)

182-192

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Economic costs of diabetes in the US in 2002.

26 July 2017

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Population-based assessment of the level of care among adults with diabetes in the U.S.

21 January 2018

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Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy

21 January 2018

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Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

21 January 2018

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Risks of progression of retinopathy and vision loss related to tight blood pressure control in type 2 diabetes mellitus: UKPDS 69.

21 January 2018

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Early breakdown of the blood-retinal barrier in diabetes

21 January 2018

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Modification of enzymatic antioxidants in retinal microvascular cells by glucose or advanced glycation end products

21 January 2018

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Ocular perfusion abnormalities in diabetes.

21 January 2018

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A new view of diabetic retinopathy: a neurodegenerative disease of the eye.

21 January 2018

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Visual electrophysiological responses in persons with type 1 diabetes

21 January 2018

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Local multifocal oscillatory potential abnormalities in diabetes and early diabetic retinopathy

21 January 2018

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The therapeutic effects of retinal laser treatment and vitrectomy. A theory based on oxygen and vascular physiology

21 January 2018

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Rod photoreceptor loss in Rho-/- mice reduces retinal hypoxia and hypoxia-regulated gene expression.

21 January 2018

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Retinopathy is reduced during experimental diabetes in a mouse model of outer retinal degeneration.

21 January 2018

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Diabetic retinopathy: surrogate outcomes for drug development for diabetic retinopathy

21 January 2018

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Vascular endothelial growth factor and diabetic retinopathy: role of oxidative stress

21 January 2018

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Effects of vitamin E on cardiovascular outcomes in people with mild-to-moderate renal insufficiency: results of the HOPE study

21 January 2018

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Reevaluation by high-performance liquid chromatography: clinical significance of microalbuminuria in individuals at high risk of cardiovascular disease in the Heart Outcomes Prevention Evaluation (HOPE) Study

21 January 2018

1 reference

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Vascular endothelial growth factor and diabetes: the agonist versus antagonist paradox

21 January 2018

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Retinal ischemia and angle neovascularization in proliferative diabetic retinopathy

21 January 2018

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Endothelial cell hypertrophy induced by vascular endothelial growth factor in the retina: new insights into the pathogenesis of capillary nonperfusion

21 January 2018

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Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders

21 January 2018

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Experimental diabetes causes breakdown of the blood-retina barrier by a mechanism involving tyrosine nitration and increases in expression of vascular endothelial growth factor and urokinase plasminogen activator receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Neuroprotective and blood-retinal barrier-preserving effects of cannabidiol in experimental diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

The potential role of PKC beta in diabetic retinopathy and macular edema

21 January 2018

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https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularization

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

The state of being noninferior

21 January 2018

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https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

VEGF-TRAP(R1R2) suppresses choroidal neovascularization and VEGF-induced breakdown of the blood-retinal barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Intravitreous anti-VEGF for diabetic retinopathy: hopes and fears for a new therapeutic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Increased prevalence of microthromboses in retinal capillaries of diabetic individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Pharmacological inhibition of diabetic retinopathy: aminoguanidine and aspirin

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Non-uniform distribution of lesions and biochemical abnormalities within the retina of diabetic humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

High glucose-induced tyrosine nitration in endothelial cells: role of eNOS uncoupling and aldose reductase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Prevention of retinal capillary basement membrane thickening in diabetic dogs by a non-steroidal anti-inflammatory drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Triamcinolone acetonide modulates permeability and intercellular adhesion molecule-1 (ICAM-1) expression of the ECV304 cell line: implications for macular degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Update on treatments for diabetic macular edema

21 January 2018

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https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Oxidative stress inactivates VEGF survival signaling in retinal endothelial cells via PI 3-kinase tyrosine nitration

21 January 2018

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https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Aldose reductase inhibition counteracts nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic rat kidney and high-glucose-exposed human mesangial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

The aldose reductase controversy

21 January 2018

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Protein kinase C activation and the development of diabetic complications

21 January 2018

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Protein kinase C activation: isozyme-specific effects on metabolism and cardiovascular complications in diabetes

21 January 2018

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Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation

21 January 2018

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Potential new medical therapies for diabetic retinopathy: protein kinase C inhibitors

21 January 2018

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Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1alpha and VEGF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Upregulation of RAGE and its ligands in proliferative retinal disease

21 January 2018

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https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

The RAGE axis in early diabetic retinopathy

21 January 2018

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https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Increased concentration of pentosidine, an advanced glycation end product, and interleukin-6 in the vitreous of patients with proliferative diabetic retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Differential accumulation of advanced glycation end products in the course of diabetic retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Advanced glycation end-products induce apoptosis of bovine retinal pericytes in culture: involvement of diacylglycerol/ceramide production and oxidative stress induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

The role of oxidative stress and NF-kappaB activation in late diabetic complications

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

The AGE inhibitor pyridoxamine inhibits development of retinopathy in experimental diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Modulatory effects of HMG-CoA reductase inhibitors in diabetic microangiopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Effects of statins on endothelium and signaling mechanisms

21 January 2018

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https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Simvastatin improves diabetes-induced coronary endothelial dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Diabetes-induced coronary vascular dysfunction involves increased arginase activity

21 January 2018

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https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Role of NADPH oxidase and Stat3 in statin-mediated protection against diabetic retinopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Simvastatin inhibits leukocyte accumulation and vascular permeability in the retinas of rats with streptozotocin-induced diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Therapeutic potential of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors for the treatment of retinal and eye diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Simvastatin retards progression of retinopathy in diabetic patients with hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptor-independent properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Efficacy and safety of dexanabinol in severe traumatic brain injury: results of a phase III randomised, placebo-controlled, clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. Heart Outcomes Prevention Evaluation Study Investigators

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Effects of vitamin E on cardiovascular and microvascular outcomes in high-risk patients with diabetes: results of the HOPE study and MICRO-HOPE substudy

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Low apparent aldose reductase activity produced by monosaccharide autoxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Biochemistry and molecular cell biology of diabetic complications

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Antioxidants attenuate early up regulation of retinal vascular endothelial growth factor in streptozotocin-diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Increased H2O2, vascular endothelial growth factor and receptors in the retina of the BBZ/Wor diabetic rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Reactive oxygen intermediates increase vascular endothelial growth factor expression in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Detection of nitrotyrosine in the diabetic plasma: evidence of oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Peroxynitrite mediates retinal neurodegeneration by inhibiting nerve growth factor survival signaling in experimental and human diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Increased superoxide anion formation in endothelial cells during hyperglycemia: an adaptive response or initial step of vascular dysfunction?

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Control of Müller glial cell proliferation and activation following retinal injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Requirement for nitric oxide in retinal neuronal cell death induced by activated Müller glial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

A role for the polyol pathway in the early neuroretinal apoptosis and glial changes induced by diabetes in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Early changes in glial reactivity and lipid peroxidation in diabetic rat retina: effects of melatonin

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Interaction between NO and COX pathways in retinal cells exposed to elevated glucose and retina of diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Diabetic retinopathy: seeing beyond glucose-induced microvascular disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Flavonoids protect retinal ganglion cells from oxidative stress-induced death

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Akt down-regulation of p38 signaling provides a novel mechanism of vascular endothelial growth factor-mediated cytoprotection in endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Hyperoxia induces retinal vascular endothelial cell apoptosis through formation of peroxynitrite

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Phosphatidylinositol 3-kinase is a target for protein tyrosine nitration

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Advanced glycosylation: chemistry, biology, and implications for diabetes and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Peroxynitrite mediates VEGF's angiogenic signal and function via a nitration-independent mechanism in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Toxic action of advanced glycation end products on cultured retinal capillary pericytes and endothelial cells: relevance to diabetic retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

Effects of intraocular or systemic administration of neutralizing antibody against vascular endothelial growth factor on the murine experimental model of retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.29.2.182

21 January 2018

Identifiers

DOI

10.1592/PHCO.29.2.182

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26 July 2017

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