Phase 1/2a study of the malaria vaccine candidate apical membrane antigen-1 (AMA-1) administered in adjuvant system AS01B or AS02A. (Q33434412)

26 July 2017

Phase 1/2a study of the malaria vaccine candidate apical membrane antigen-1 (AMA-1) administered in adjuvant system AS01B or AS02A. (English)

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26 July 2017

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Kent E Kester

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Elke S Bergmann-Leitner

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Elke Bergmann-Leitner

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Robert W Sauerwein

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Robert W Sauerwein

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Carole Long

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W Ripley Ballou

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Opokua Ofori-Anyinam

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Marie-Claude Dubois

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Christian F Ockenhouse

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Evelina Angov

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D Gray Heppner

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Sheetij Dutta

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Kathryn Tucker

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Carter L Diggs

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Elissa Malkin

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Lorraine Soisson

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Michele D Spring

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Urszula Krzych

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Lisa A Ware

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Cornelus C Hermsen

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David E Lanar

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Megan Dowler

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Robin Nielsen

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Sake J de Vlas

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language of work or name

English

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publication date

23 April 2009

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e5254

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Creative Commons CC0 License

26 July 2017

start time

23 April 2009

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April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

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cites work

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Safety and immunogenicity of an AMA-1 malaria vaccine in Malian adults: results of a phase 1 randomized controlled trial

21 June 2018

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GlaxoSmithKline Adjuvant Systems in vaccines: concepts, achievements and perspectives

21 June 2018

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21 June 2018

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Structural basis of antigenic escape of a malaria vaccine candidate

21 June 2018

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Phase I dose escalation safety and immunogenicity trial of Plasmodium falciparum apical membrane protein (AMA-1) FMP2.1, adjuvanted with AS02A, in malaria-naïve adults at the Walter Reed Army Institute of Research.

21 June 2018

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Phase 1 study of two merozoite surface protein 1 (MSP1(42)) vaccines for Plasmodium falciparum malaria

21 June 2018

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Dynamics of polymorphism in a malaria vaccine antigen at a vaccine-testing site in Mali

21 June 2018

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Phenotypic diversity in delayed drug hypersensitivity: an immunologic explanation

21 June 2018

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A DNA prime-modified vaccinia virus ankara boost vaccine encoding thrombospondin-related adhesion protein but not circumsporozoite protein partially protects healthy malaria-naive adults against Plasmodium falciparum sporozoite challenge.

21 June 2018

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Malaria in the pregnant woman

21 June 2018

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A malaria vaccine that elicits in humans antibodies able to kill Plasmodium falciparum

21 June 2018

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Durable human memory T cells quantifiable by cultured enzyme-linked immunospot assays are induced by heterologous prime boost immunization and correlate with protection against malaria

21 June 2018

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Characterization of a human reference standard for antibody to Plasmodium falciparum merozoite surface protein 1(42).

21 June 2018

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Phase 1 clinical trial of apical membrane antigen 1: an asexual blood-stage vaccine for Plasmodium falciparum malaria

21 June 2018

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Towards an RTS,S-based, multi-stage, multi-antigen vaccine against falciparum malaria: progress at the Walter Reed Army Institute of Research.

21 June 2018

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Human antibodies to recombinant protein constructs of Plasmodium falciparum Apical Membrane Antigen 1 (AMA1) and their associations with protection from malaria

21 June 2018

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Malaria vaccine developments

21 June 2018

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Apical membrane antigen 1, a major malaria vaccine candidate, mediates the close attachment of invasive merozoites to host red blood cells

21 June 2018

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A role for apical membrane antigen 1 during invasion of hepatocytes by Plasmodium falciparum sporozoites

21 June 2018

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Vaccination of monkeys with recombinant Plasmodium falciparum apical membrane antigen 1 confers protection against blood-stage malaria

21 June 2018

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21 June 2018

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Purification, characterization, and immunogenicity of the refolded ectodomain of the Plasmodium falciparum apical membrane antigen 1 expressed in Escherichia coli

21 June 2018

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Proteolytic processing and primary structure of Plasmodium falciparum apical membrane antigen-1.

21 June 2018

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Specificity of the protective antibody response to apical membrane antigen 1

21 June 2018

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Efficacy of recombinant circumsporozoite protein vaccine regimens against experimental Plasmodium falciparum malaria.

21 June 2018

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Effect of vaccination with 3 recombinant asexual-stage malaria antigens on initial growth rates of Plasmodium falciparum in non-immune volunteers

21 June 2018

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Immunisation with recombinant AMA-1 protects mice against infection with Plasmodium chabaudi

21 June 2018

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Identification of T-cell determinants in natural immune responses to the Plasmodium falciparum apical membrane antigen (AMA-1) in an adult population exposed to malaria

21 June 2018

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T lymphocytes from volunteers immunized with irradiated Plasmodium falciparum sporozoites recognize liver and blood stage malaria antigens.

21 June 2018

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Malaria transmitted to humans by mosquitoes infected from cultured plasmodium falciparum

21 June 2018

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Vaccination trials in rhesus monkeys with a minor, invariant, Plasmodium knowlesi 66 kD merozoite antigen.

21 June 2018

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Improved T cell responses to Plasmodium falciparum circumsporozoite protein in mice and monkeys induced by a novel formulation of RTS,S vaccine antigen

21 June 2018

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Pre-clinical evaluation of the malaria vaccine candidate P. falciparum MSP1(42) formulated with novel adjuvants or with alum.

21 January 2018

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Pre-clinical evaluation of new adjuvant formulations to improve the immunogenicity of the malaria vaccine RTS,S/AS02A.

21 January 2018

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Phase 2a trial of 0, 1, and 3 month and 0, 7, and 28 day immunization schedules of malaria vaccine RTS,S/AS02 in malaria-naïve adults at the Walter Reed Army Institute of Research

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005254

A phase I/IIa safety, immunogenicity, and efficacy bridging randomized study of a two-dose regimen of liquid and lyophilized formulations of the candidate malaria vaccine RTS,S/AS02A in malaria-naïve adults.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005254

Phase I safety and immunogenicity trial of FMP1/AS02A, a Plasmodium falciparum MSP-1 asexual blood stage vaccine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005254

Protective immunity induced with malaria vaccine, RTS,S, is linked to Plasmodium falciparum circumsporozoite protein-specific CD4+ and CD8+ T cells producing IFN-gamma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005254

Critical evaluation of different methods for measuring the functional activity of antibodies against malaria blood stage antigens.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669163

Quantitative real-time polymerase chain reaction for malaria diagnosis and its use in malaria vaccine clinical trials.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669163

Testing vaccines in human experimental malaria: statistical analysis of parasitemia measured by a quantitative real-time polymerase chain reaction

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669163

Detection of Plasmodium falciparum malaria parasites in vivo by real-time quantitative PCR.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669163

Longitudinal study of natural immune responses to the Plasmodium falciparum apical membrane antigen (AMA-1) in a holoendemic region of malaria in western Kenya: Asembo Bay Cohort Project VIII.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669163

10.1371/JOURNAL.PONE.0005254

31 October 2018

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DOI

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26 July 2017

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26 July 2017

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