The immunosuppressive properties of the HIV Vpr protein are linked to a single highly conserved residue, R90 (Q33466002)

27 July 2017

title

The immunosuppressive properties of the HIV Vpr protein are linked to a single highly conserved residue, R90 (English)

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27 July 2017

Irina Tcherepanova

1

1 reference

27 July 2017

Aijing Starr

2

1 reference

27 July 2017

Brad Lackford

3

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27 July 2017

Melissa D Adams

4

1 reference

27 July 2017

Jean-Pierre Routy

5

1 reference

27 July 2017

Mohamed Rachid Boulassel

6

1 reference

27 July 2017

David Calderhead

7

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27 July 2017

Don Healey

8

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27 July 2017

Charles Nicolette

9

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27 July 2017

language of work or name

English

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publication date

10 June 2009

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27 July 2017

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27 July 2017

volume

4

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27 July 2017

issue

6

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27 July 2017

page(s)

e5853

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Creative Commons Attribution 4.0 International

27 July 2017

copyright license

start time

10 June 2009

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Ectopic expression of a truncated CD40L protein from synthetic post-transcriptionally capped RNA in dendritic cells induces high levels of IL-12 secretion

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Priming of a novel subset of CD28+ rapidly expanding high-avidity effector memory CTL by post maturation electroporation-CD40L dendritic cells is IL-12 dependent

21 June 2018

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Impaired nuclear import and viral incorporation of Vpr derived from a HIV long-term non-progressor

21 June 2018

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HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral load

21 June 2018

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Multiplex RT-PCR amplification of HIV genes to create a completely autologous DC-based immunotherapy for the treatment of HIV infection

21 June 2018

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Development of a potency assay for human dendritic cells: IL-12p70 production.

21 June 2018

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Vpr and HIV-1 disease progression: R77Q mutation is associated with long-term control of HIV-1 infection in different groups of patients

21 June 2018

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21 June 2018

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Human immunodeficiency virus type 1 Vpr impairs dendritic cell maturation and T-cell activation: implications for viral immune escape

21 June 2018

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The C-terminal domain of the HIV-1 regulatory protein Vpr adopts an antiparallel dimeric structure in solution via its leucine-zipper-like domain

21 June 2018

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CD8+ T-cells: function and response to HIV infection

21 June 2018

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Mitochondrion-mediated apoptosis in HIV-1 infection

21 June 2018

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Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis

21 June 2018

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The mitochondriotoxic domain of Vpr determines HIV-1 virulence

21 June 2018

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Cascades of transcriptional induction during dendritic cell maturation revealed by genome-wide expression analysis

21 June 2018

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HIV-1 protein Vpr suppresses IL-12 production from human monocytes by enhancing glucocorticoid action: potential implications of Vpr coactivator activity for the innate and cellular immunity deficits observed in HIV-1 infection

21 June 2018

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Functional role of residues corresponding to helical domain II (amino acids 35 to 46) of human immunodeficiency virus type 1 Vpr.

21 June 2018

1 reference

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Human immunodeficiency virus type 1 Vpr protein is incorporated into the virion in significantly smaller amounts than gag and is phosphorylated in infected cells

21 June 2018

1 reference

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NMR structure of the (52-96) C-terminal domain of the HIV-1 regulatory protein Vpr: molecular insights into its biological functions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2689350

A signature motif in transcriptional co-activators mediates binding to nuclear receptors

21 June 2018

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A TH1-->TH2 switch is a critical step in the etiology of HIV infection

21 June 2018

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Impaired interleukin 12 production in human immunodeficiency virus-infected patients

21 June 2018

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Defective accessory genes in a human immunodeficiency virus type 1-infected long-term survivor lacking recoverable virus

21 June 2018

1 reference

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Cytokine maturation followed by CD40L mRNA electroporation results in a clinically relevant dendritic cell product capable of inducing a potent proinflammatory CTL response.

21 June 2018

1 reference

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Evidence for host-driven selection of the HIV type 1 vpr gene in vivo during HIV disease progression in a transfusion-acquired cohort

31 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2689350

Rapid high efficiency sensitization of CD8+ T cells to tumor antigens by dendritic cells leads to enhanced functional avidity and direct tumor recognition through an IL-12-dependent mechanism

31 October 2018

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Near full-length clones and reference sequences for subtype C isolates of HIV type 1 from three different continents.

31 October 2018

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Peripheral burst of tumor-specific cytotoxic T lymphocytes and infiltration of metastatic lesions by memory CD8+ T cells in melanoma patients receiving interleukin 12.

31 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2689350

HIV-1 Vpr inhibits the maturation and activation of macrophages and dendritic cells in vitro

31 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2689350

Gene Defects Clustered at the C-Terminus of the vpr Gene of HIV-1 in Long-Term Nonprogressing Mother and Child Pair:In VivoEvolution of vpr Quasispecies in Blood and Plasma

31 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2689350

Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells

31 October 2018

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12 December 2020

Vpr Is Preferentially Targeted by CTL During HIV-1 Infection

1 reference

12 December 2020

Functional conservation of HIV-1 Vpr and variability in a mother–child pair of long-term non-progressors

1 reference

12 December 2020

Inclusion of Vpr accessory gene in a plasmid vaccine cocktail markedly reduces Nef vaccine effectiveness in vivo resulting in CD4 cell loss and increased viral loads in rhesus macaques

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12 December 2020

Cytotoxic T-lymphocyte (CTL) responses directed against regulatory and accessory proteins in HIV-1 infection

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12 December 2020

Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro

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12 December 2020

10.1371/JOURNAL.PONE.0005853

Identifiers

DOI

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27 July 2017

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27 July 2017

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