Practical anticipation of human efficacious doses and pharmacokinetics using in vitro and preclinical in vivo data (Q33496817)

27 July 2017

Practical anticipation of human efficacious doses and pharmacokinetics using in vitro and preclinical in vivo data (English)

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27 July 2017

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Tycho Heimbach

1

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27 July 2017

Suresh B Lakshminarayana

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2

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27 July 2017

Wenyu Hu

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3

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27 July 2017

Handan He

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4

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27 July 2017

language of work or name

English

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publication date

26 August 2009

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27 July 2017

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27 July 2017

11

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27 July 2017

3

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27 July 2017

602-614

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https://scigraph.springernature.com/pub.10.1208/s12248-009-9136-x

27 July 2017

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Early integration of pharmacokinetic and dynamic reasoning is essential for optimal development of lead compounds: strategic considerations

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21 June 2018

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21 June 2018

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21 June 2018

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On the anticipation of the human dose in first-in-man trials from preclinical and prior clinical information in early drug development

21 June 2018

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21 June 2018

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The road map to oral bioavailability: an industrial perspective

21 June 2018

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Prediction of human drug clearance from animal data: application of the rule of exponents and 'fu Corrected Intercept Method' (FCIM).

21 June 2018

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How modeling and simulation have enhanced decision making in new drug development

21 June 2018

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IV-IVC considerations in the development of immediate-release oral dosage form

21 June 2018

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Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases.

21 June 2018

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Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approaches

21 June 2018

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21 June 2018

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Predicting the impact of physiological and biochemical processes on oral drug bioavailability

21 June 2018

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Transport approaches to the biopharmaceutical design of oral drug delivery systems: prediction of intestinal absorption

21 June 2018

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Drug-like properties and the causes of poor solubility and poor permeability

21 June 2018

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Prediction of adipose tissue: plasma partition coefficients for structurally unrelated drugs

21 June 2018

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Prediction of hepatic metabolic clearance based on interspecies allometric scaling techniques and in vitro-in vivo correlations

21 June 2018

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Linear correlation of the fraction of oral dose absorbed of 64 drugs between humans and rats

21 June 2018

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Oral bioavailability and first-pass effects

21 June 2018

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Basic concepts of pharmacokinetic/pharmacodynamic (PK/PD) modelling

21 June 2018

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The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data.

21 June 2018

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A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability

21 June 2018

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Effect of Altered Plasma Protein Binding on Apparent Volume of Distribution

21 June 2018

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Prediction of Phase I single-dose pharmacokinetics using recombinant cytochromes P450 and physiologically based modelling

21 June 2018

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Predicting oral clearance in humans: how close can we get with allometry?

31 October 2018

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Projection of exposure and efficacious dose prior to first-in-human studies: how successful have we been?

31 October 2018

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Prediction of human pharmacokinetics using physiologically based modeling: a retrospective analysis of 26 clinically tested drugs.

31 October 2018

1 reference

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Predicting pharmacokinetic food effects using biorelevant solubility media and physiologically based modelling.

31 October 2018

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Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions.

31 October 2018

1 reference

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A novel model for prediction of human drug clearance by allometric scaling

31 October 2018

1 reference

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A mathematical description of the functionality of correction factors used in allometry for predicting human drug clearance.

31 October 2018

1 reference

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Molecular properties of WHO essential drugs and provisional biopharmaceutical classification

31 October 2018

1 reference

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Prediction of human pharmacokinetic profile in animal scale up based on normalizing time course profiles.

31 October 2018

1 reference

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Physiologically Based Pharmacokinetic (PBPK) Modeling of Disposition of Epiroprim in Humans

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758129

A priori prediction of tissue:plasma partition coefficients of drugs to facilitate the use of physiologically-based pharmacokinetic models in drug discovery.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758129

A comparative study of allometric scaling with plasma concentrations predicted by species-invariant time methods.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758129

Quantitative Relations in the Physiological Constitutions of Mammals

31 October 2018

1 reference

12 December 2020

Development of clinical dosage forms for a poorly water soluble drug I: Application of polyethylene glycol-polysorbate 80 solid dispersion carrier system

1 reference

12 December 2020

Interspecies correlation of plasma concentration history of methotrexate (NSC-740)

1 reference

12 December 2020

Physiological parameters in laboratory animals and humans

1 reference

12 December 2020

Physiologic indirect response models characterize diverse types of pharmacodynamic effects

1 reference

12 December 2020

Interpatient variability in bioavailability is related to the extent of absorption: implications for bioavailability and bioequivalence studies

1 reference

12 December 2020

Application of full physiological models for pharmaceutical drug candidate selection and extrapolation of pharmacokinetics to man

1 reference

12 December 2020

A novel strategy for physiologically based predictions of human pharmacokinetics

1 reference

12 December 2020

Prediction of human pharmacokinetics from preclinical information: comparative accuracy of quantitative prediction approaches

1 reference

12 December 2020

10.1208/S12248-009-9136-X

Identifiers

DOI

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Dimensions Publication ID

27 July 2017

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27 July 2017

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