An anticoagulant RNA aptamer that inhibits proteinase-cofactor interactions within prothrombinase (Q33519836)

27 July 2017

title

An anticoagulant RNA aptamer that inhibits proteinase-cofactor interactions within prothrombinase (English)

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27 July 2017

1 reference

1 reference

Dougald M Monroe

6

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Sriram Krishnaswamy

7

object named as

Sriram Krishnaswamy

1 reference

27 July 2017

Sai K Buddai

1

1 reference

27 July 2017

Juliana M Layzer

2

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27 July 2017

Genmin Lu

3

1 reference

27 July 2017

Christopher P Rusconi

4

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27 July 2017

Bruce A Sullenger

5

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27 July 2017

language of work or name

English

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publication date

18 December 2009

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Journal of Biological Chemistry

27 July 2017

published in

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27 July 2017

volume

285

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27 July 2017

issue

8

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27 July 2017

page(s)

5212-5223

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Crystal structure of an RNA aptamer bound to thrombin

27 July 2017

cites work

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14 July 2018

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Factor VIII accelerates proteolytic cleavage of von Willebrand factor by ADAMTS13.

14 July 2018

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The conformational switch from the factor X zymogen to protease state mediates exosite expression and prothrombinase assembly

14 July 2018

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New anticoagulants for treatment of venous thromboembolism

14 July 2018

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Restricted active site docking by enzyme-bound substrate enforces the ordered cleavage of prothrombin by prothrombinase

14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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Binding of substrate in two conformations to human prothrombinase drives consecutive cleavage at two sites in prothrombin

14 July 2018

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14 July 2018

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RNA aptamers as reversible antagonists of coagulation factor IXa.

14 July 2018

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Nematode anticoagulant protein c2 reveals a site on factor Xa that is important for macromolecular substrate binding to human prothrombinase

14 July 2018

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Generation of species cross-reactive aptamers using "toggle" SELEX.

14 July 2018

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Blocking the initiation of coagulation by RNA aptamers to factor VIIa

14 July 2018

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Preparation, characterization, and the crystal structure of the inhibitor ZK-807834 (CI-1031) complexed with factor Xa

14 July 2018

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Antithrombin. A bloody important serpin.

14 July 2018

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Comparison of the electrophoretic and hydrodynamic properties of DNA and RNA oligonucleotide duplexes

14 July 2018

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X-ray structure of active site-inhibited clotting factor Xa. Implications for drug design and substrate recognition

14 July 2018

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14 July 2018

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The single-stranded DNA aptamer-binding site of human thrombin.

14 July 2018

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Structure of human des(1-45) factor Xa at 2.2 A resolution

14 July 2018

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Cofactor proteins in the assembly and expression of blood clotting enzyme complexes

14 July 2018

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Calcium binding to the isolated beta-hydroxyaspartic acid-containing epidermal growth factor-like domain of bovine factor X.

14 July 2018

1 reference

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Calculation of protein extinction coefficients from amino acid sequence data

14 July 2018

1 reference

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Prothrombinase complex assembly. Contributions of protein-protein and protein-membrane interactions toward complex formation

14 July 2018

1 reference

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Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase

14 July 2018

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Surface-dependent reactions of the vitamin K-dependent enzyme complexes

14 July 2018

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DEGR-factor Xa blocks disseminated intravascular coagulation initiated by Escherichia coli without preventing shock or organ damage.

14 July 2018

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Quantitative evaluation of solution equilibrium binding interactions by affinity partitioning: application to specific and nonspecific protein-heparin interactions.

14 July 2018

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In vitro selection of RNA molecules that bind specific ligands

14 July 2018

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Molecular recognition sites on factor Xa which participate in the prothrombinase complex

14 July 2018

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Molecular and cellular biology of blood coagulation

14 July 2018

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Activation of human factor X (Stuart factor) by a protease from Russell's viper venom

14 July 2018

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Activation of human factor IX (Christmas factor)

14 July 2018

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Binding site for blood coagulation factor Xa involving residues 311-325 in factor Va.

14 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.049833

Extended interactions with prothrombinase enforce affinity and specificity for its macromolecular substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.049833

Formation of factors IXa and Xa by the extrinsic pathway: differential regulation by tissue factor pathway inhibitor and antithrombin III.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.049833

Sedimentation equilibrium analysis of protein interactions with global implicit mass conservation constraints and systematic noise decomposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.049833

RNA aptamer to thrombin binds anion-binding exosite-2 and alters protease inhibition by heparin-binding serpins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.049833

Principles of Fluorescence Spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.049833

A monoclonal antibody which inhibits the factor Va:factor Xa interaction.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820749

Exosite interactions determine the affinity of factor X for the extrinsic Xase complex

31 October 2018

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12 December 2020

Isolation and characterization of human factor VII. Activation of factor VII by factor Xa

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12 December 2020

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12 December 2020

Solution composition dependent variation in extinction coefficients for p-nitroaniline

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12 December 2020

Interaction of clotting factor V heavy chain with prothrombin and prethrombin 1 and role of activated protein C in regulating this interaction: analysis by analytical ultracentrifugation

1 reference

12 December 2020

Human factor VIIIa subunit structure. Reconstruction of factor VIIIa from the isolated A1/A3-C1-C2 dimer and A2 subunit

1 reference

12 December 2020

Intrinsic pathway activation of factor X and its activation peptide-deficient derivative, factor Xdes-143-191

1 reference

12 December 2020

The activation of prothrombin by the prothrombinase complex. The contribution of the substrate-membrane interaction to catalysis

1 reference

12 December 2020

Role of the activation peptide domain in human factor X activation by the extrinsic Xase complex

1 reference

12 December 2020

Contribution of the prothrombin fragment 2 domain to the function of factor Va in the prothrombinase complex

1 reference

12 December 2020

Exosites determine macromolecular substrate recognition by prothrombinase

1 reference

12 December 2020

Regulation of extrinsic pathway factor Xa formation by tissue factor pathway inhibitor

1 reference

12 December 2020

Regions remote from the site of cleavage determine macromolecular substrate recognition by the prothrombinase complex

1 reference

12 December 2020

Defining epitopes: It's not as easy as it seems

1 reference

12 December 2020

Antidote-mediated control of an anticoagulant aptamer in vivo

1 reference

12 December 2020

Proposed structural models of human factor Va and prothrombinase

1 reference

12 December 2020

1 reference

12 December 2020

Identification of a binding site for blood coagulation factor Xa on the heavy chain of factor Va. Amino acid residues 323-331 of factor V represent an interactive site for activated factor X

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M109.049833

1 reference

27 July 2017

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27 July 2017

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