Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2 (Q33521938)

27 July 2017

Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2 (English)

1 reference

27 July 2017

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1 reference

1 reference

Louise J Barber

3

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Christopher J Lord

object named as

Christopher J Lord

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6

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Darren J. Burgess

object named as

Darren J Burgess

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4

0 references

Alan Ashworth

series ordinal

7

object named as

Alan Ashworth

1 reference

27 July 2017

2

Afshan McCarthy

1 reference

27 July 2017

5

Suzanne Parry

1 reference

27 July 2017

Sarah A Martin

1

1 reference

27 July 2017

1 September 2009

1 reference

27 July 2017

EMBO Molecular Medicine

1 reference

27 July 2017

1

1 reference

27 July 2017

323-337

1 reference

27 July 2017

6-7

1 reference

Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs.

27 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

New approaches to molecular cancer therapeutics

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

The role of the human DNA mismatch repair gene hMSH2 in DNA repair, cell cycle control and apoptosis: implications for pathogenesis, progression and therapy of cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

Different DNA repair strategies to combat the threat from 8-oxoguanine.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

Adjuvant therapy in colon cancer--what, when and how?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

Signalling cell cycle arrest and cell death through the MMR System

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

Mismatch repair status in the prediction of benefit from adjuvant fluorouracil chemotherapy in colorectal cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

Probing tumor phenotypes using stable and regulated synthetic microRNA precursors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

8-oxoguanine incorporation into DNA repeats in vitro and mismatch recognition by MutSalpha

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

The concept of synthetic lethality in the context of anticancer therapy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

Mismatch repair participates in error-free processing of DNA interstrand crosslinks in human cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

Adjuvant sequential methotrexate --> 5-fluorouracil vs 5-fluorouracil plus leucovorin in radically resected stage III and high-risk stage II colon cancer.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

Methylation demand: a key determinant of homocysteine metabolism.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

Enhanced radiosensitization with gemcitabine in mismatch repair-deficient HCT116 cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

Folate deficiency, mismatch repair-dependent apoptosis, and human disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

Role of hMLH1 promoter hypermethylation in drug resistance to 5-fluorouracil in colorectal cancer cell lines.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

Germline, somatic and epigenetic events underlying mismatch repair deficiency in colorectal and HNPCC-related cancers.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

DNA mismatch repair defects: role in colorectal carcinogenesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

Regulation of beta-amyloid stimulated proinflammatory responses by peroxisome proliferator-activated receptor alpha

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

Suppression of gene amplification and chromosomal DNA integration by the DNA mismatch repair system

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

The molecular perspective: methotrexate

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

Functional overlap in mismatch repair by human MSH3 and MSH6.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

Correction of hypermutability, N-methyl-N'-nitro-N-nitrosoguanidine resistance, and defective DNA mismatch repair by introducing chromosome 2 into human tumor cells with mutations in MSH2 and MSH6.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

Microsatellite instability, mismatch repair deficiency, and genetic defects in human cancer cell lines.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

Genetics, natural history, surveillance, management, and gene mapping in the Lynch syndrome.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

Selenium: Biochemical Role as a Component of Glutathione Peroxidase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair

28 July 2018

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.200900040

Role of poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.200900040

The mammalian mismatch repair pathway removes DNA 8-oxodGMP incorporated from the oxidized dNTP pool

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.200900040

The frequency of hereditary defective mismatch repair in a prospective series of unselected colorectal carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.200900040

Different effects of methotrexate on DNA mismatch repair proficient and deficient cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.200900040

Clinical management of hereditary colorectal cancer syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.200900040

Parthenolide induces a distinct pattern of oxidative stress in cardiac myocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.200900040

Homocysteine, the bad thiol

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.200900040

Anticancer Antifolates: Current Status and Future Directions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.200900040

Distinct mechanisms of site-specific oxidative DNA damage by doxorubicin in the presence of copper(II) and NADPH-cytochrome P450 reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.200900040

Mismatch repair and the hereditary non-polyposis colorectal cancer syndrome (HNPCC)

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.200900040

Finding new tricks for old drugs: an efficient route for public-sector drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.200900040

Cloning of short hairpin RNAs for gene knockdown in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.200900040

Effects of selenium compounds on induction of DNA damage by broadband ultraviolet radiation in human keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.200900040

Oxidative stress induced by methotrexate alone and in the presence of methanol in discrete regions of the rodent brain, retina and optic nerve.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.200900040

8-Hydroxy-2'-deoxyguanosine (8-OH-dG) as a potential survival biomarker in patients with nonsmall-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.200900040

Acquired genomic aberrations associated with methotrexate resistance vary with background genomic instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.200900040

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.200900040

A density-based proteomics sample fractionation technology: folate deficiency induced oxidative stress response in liver and brain

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

The role of apoptosis in cancer development and treatment response

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea sensitivity in mismatch repair-defective human cells.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

Long-term folate deficiency alters folate content and distribution differentially in rat tissues

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378145

Involvement of DNA mismatch repair in folate deficiency-induced apoptosis☆

31 October 2018

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.200900040

Causes of microsatellite instability in colorectal tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.200900040

Pancreatic one-carbon metabolism in early folate deficiency in rats

21 January 2018

1 reference

12 December 2020

Selective radiosensitization of drug-resistant MutS homologue-2 (MSH2) mismatch repair-deficient cells by halogenated thymidine (dThd) analogues: Msh2 mediates dThd analogue DNA levels and the differential cytotoxicity and cell cycle effects of the

1 reference

12 December 2020

Mutations predisposing to hereditary nonpolyposis colorectal cancer: Database and results of a collaborative study. The International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer

1 reference

12 December 2020

Mutagenic and carcinogenic potential of menadione

1 reference

12 December 2020

Identifiers

DOI

10.1002/EMMM.200900040

1 reference

27 July 2017

1 reference

27 July 2017

1 reference

PubMed ID

20049736