Design and discovery of protein dimerizers (Q33533844)

27 July 2017

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title

Design and discovery of protein dimerizers (English)

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27 July 2017

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Clemons PA

1

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27 July 2017

1 February 1999

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Current Opinion in Chemical Biology

27 July 2017

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27 July 2017

3

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27 July 2017

1

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27 July 2017

112-115

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Making agonists of antagonists

27 July 2017

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Proximity versus allostery: the role of regulated protein dimerization in biology

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Dimerization as a regulatory mechanism in signal transduction

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Dimerization of cell surface receptors in signal transduction

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A small, nonpeptidyl mimic of granulocyte-colony-stimulating factor [see commetns].

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Activation of the erythropoietin (EPO) receptor by bivalent anti-EPO receptor antibodies

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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

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A mammalian protein targeted by G1-arresting rapamycin-receptor complex

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Inducible gene expression and protein translocation using nontoxic ligands identified by a mammalian three-hybrid screen

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Controlling signal transduction with synthetic ligands

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7 January 2021

Mechanistic studies of a signaling pathway activated by the organic dimerizer FK1012

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Small-molecule control of insulin and PDGF receptor signaling and the role of membrane attachment

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Higher order iminodiacetic acid libraries for probing protein-protein interactions

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A new type of synthetic peptide library for identifying ligand-binding activity

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Small molecule-dependent genetic selection in stochastic nanodroplets as a means of detecting protein-ligand interactions on a large scale

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A miniaturized arrayed assay format for detecting small molecule-protein interactions in cells

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A yeast genetic system for selecting small molecule inhibitors of protein-protein interactions in nanodroplets

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High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications

1 reference

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7 January 2021

10.1016/S1367-5931(99)80020-9

Identifiers

DOI

1 reference

27 July 2017

1 reference

PubMed ID

10021413