Differential signalling by variant ligands of the T cell receptor and the kinetic model of T cell activation (Q33540756)

27 July 2017

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title

Differential signalling by variant ligands of the T cell receptor and the kinetic model of T cell activation (English)

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27 July 2017

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Madrenas J

1

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27 July 2017

language of work or name

English

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publication date

1 January 1999

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27 July 2017

number of pages

15

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based on heuristic

inferred from page(s)

published in

Life Sciences

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27 July 2017

volume

64

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27 July 2017

issue

9

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27 July 2017

page(s)

717-731

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MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation

27 July 2017

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Essential flexibility in the T-cell recognition of antigen

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Differential signaling by lymphocyte antigen receptors.

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Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor

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Structural basis for T cell recognition of altered peptide ligands: a single T cell receptor can productively recognize a large continuum of related ligands

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Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands

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7 January 2021

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The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands

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T cell receptor antagonists and partial agonists

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In vivo competition between self peptides and foreign antigens in T-cell activation

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Competition for antigen presentation in living cells involves exchange of peptides bound by class II MHC molecules

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Analogs that compete for antigen binding to an arsonate-reactive T-cell clone inhibit the functional response to arsonate

7 January 2021

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Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand

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Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells

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7 January 2021

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Antigen analogs/MHC complexes as specific T cell receptor antagonists

7 January 2021

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Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology

7 January 2021

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MHC restriction in three dimensions: a view of T cell receptor/ligand interactions

7 January 2021

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Specificity pockets for the side chains of peptide antigens in HLA-Aw68

7 January 2021

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Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1.

7 January 2021

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T-cell antigen receptor genes and T-cell recognition

7 January 2021

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Mapping T-cell receptor–peptide contacts by variant peptide immunization of single-chain transgenics

7 January 2021

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The specificity and orientation of a TCR to its peptide-MHC class II ligands

7 January 2021

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Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen

7 January 2021

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An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex

7 January 2021

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Structure of the complex between human T-cell receptor, viral peptide and HLA-A2

7 January 2021

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Low Affinity Interaction of Peptide-MHC Complexes with T Cell Receptors

7 January 2021

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T cell receptor-MHC class I peptide interactions: affinity, kinetics, and specificity

7 January 2021

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Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation

7 January 2021

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The minimal number of class II MHC-antigen complexes needed for T cell activation

7 January 2021

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Serial triggering of many T-cell receptors by a few peptide-MHC complexes

7 January 2021

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Understanding the mechanisms of sustained signaling and T cell activation

7 January 2021

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Degradation of T cell receptor (TCR)-CD3-zeta complexes after antigenic stimulation

7 January 2021

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Peptide-induced T cell receptor down-regulation on naive T cells predicts agonist/partial agonist properties and strictly correlates with T cell activation

7 January 2021

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Serial engagement proposed

7 January 2021

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Ligand-specific oligomerization of T-cell receptor molecules

7 January 2021

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Nonmitogenic anti-CD3 monoclonal antibodies deliver a partial T cell receptor signal and induce clonal anergy

7 January 2021

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Ligands for the T-cell receptor: hard times for avidity models

7 January 2021

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A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists

7 January 2021

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T-cell-receptor affinity and thymocyte positive selection

7 January 2021

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Inhibition or activation of human T cell receptor transfectants is controlled by defined, soluble antigen arrays

7 January 2021

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Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases

7 January 2021

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ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency

7 January 2021

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Essential role for ZAP-70 in both positive and negative selection of thymocytes

7 January 2021

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LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

7 January 2021

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Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

7 January 2021

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Signal transmission between the plasma membrane and nucleus of T lymphocytes

7 January 2021

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NF-AT components define a family of transcription factors targeted in T-cell activation

7 January 2021

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Altered T cell receptor ligands trigger a subset of early T cell signals

7 January 2021

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Kinetics and extent of T cell activation as measured with the calcium signal

7 January 2021

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The MAPK signaling cascade

7 January 2021

1 reference

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A comparison of the interaction of Shc and the tyrosine kinase ZAP-70 with the T cell antigen receptor zeta chain tyrosine-based activation motif

7 January 2021

1 reference

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T cell antigen receptor signal transduction pathways

7 January 2021

1 reference

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The activation of phosphatidylinositol 3-kinase by Ras

7 January 2021

1 reference

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Ligation of CD28 receptor by B7 induces formation of D-3 phosphoinositides in T lymphocytes independently of T cell receptor/CD3 activation

7 January 2021

1 reference

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Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk.

7 January 2021

1 reference

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Itk and Fyn make independent contributions to T cell activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2898%2900381-6

A T cell receptor (TCR) antagonist competitively inhibits serial TCR triggering by low-affinity ligands, but does not affect triggering by high-affinity anti-CD3 antibodies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2898%2900381-6

Both high and low avidity antibodies to the T cell receptor can have agonist or antagonist activity

7 January 2021

1 reference

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Partial T cell signaling: altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2898%2900381-6

Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2898%2900381-6

Partial signaling by CD8+ T cells in response to antagonist ligands

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2898%2900381-6

ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2898%2900381-6

Dissociation of intracellular signaling pathways in response to partial agonist ligands of the T cell receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2898%2900381-6

Selective activation of the calcium signaling pathway by altered peptide ligands

7 January 2021

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The mechanism of action of cyclosporin A and FK506

7 January 2021

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ZAP-70-dependent and -independent activation of Erk in Jurkat T cells. Differences in signaling induced by H2o2 and Cd3 cross-linking

7 January 2021

1 reference

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Signal transduction from multiple Ras effectors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2898%2900381-6

ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR ζ in murine thymocytes and lymph node T cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2898%2900381-6

TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck

7 January 2021

1 reference

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Impaired plasma membrane targeting of Grb2-murine son of sevenless (mSOS) complex and differential activation of the Fyn-T cell receptor (TCR)-zeta-Cbl pathway mediate T cell hyporesponsiveness in autoimmune nonobese diabetic mice

7 January 2021

1 reference

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Rapid tyrosine phosphorylation of Grb2 and Shc in T cells exposed to anti-CD3, anti-CD4, and anti-CD45 stimuli: differential effects of aging

7 January 2021

1 reference

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Diminished activation of the MAP kinase pathway in CD3-stimulated T lymphocytes from old mice.

7 January 2021

1 reference

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The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation

7 January 2021

1 reference

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Amino acid residues that flank core peptide epitopes and the extracellular domains of CD4 modulate differential signaling through the T cell receptor

7 January 2021

1 reference

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CD4 augments the response of a T cell to agonist but not to antagonist ligands

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2898%2900381-6

Specificity and flexibility in thymic selection

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2898%2900381-6

Endogenous altered peptide ligands can affect peripheral T cell responses

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2898%2900381-6

Signals and signs for lymphocyte responses

7 January 2021

1 reference

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The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction

7 January 2021

1 reference

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Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand

7 January 2021

1 reference

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Single cell analysis reveals regulated hierarchical T cell antigen receptor signaling thresholds and intraclonal heterogeneity for individual cytokine responses of CD4+ T cells

7 January 2021

1 reference

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Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2898%2900381-6

Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2898%2900381-6

Differential activation of transcription factors induced by Ca2+ response amplitude and duration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2898%2900381-6

Making the T cell receptor go the distance: a topological view of T cell activation

7 January 2021

1 reference

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T cell activation determined by T cell receptor number and tunable thresholds.

7 January 2021

1 reference

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The two membrane proximal domains of CD4 interact with the T cell receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2898%2900381-6

Dimeric association and segmental variability in the structure of human CD4

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2898%2900381-6

Identification of a CD4 binding site on the beta 2 domain of HLA-DR molecules.

7 January 2021

1 reference

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MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8

7 January 2021

1 reference

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Involvement of both major histocompatibility complex class II alpha and beta chains in CD4 function indicates a role for ordered oligomerization in T cell activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2898%2900381-6

Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2898%2900381-6

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7 January 2021

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DOI

10.1016/S0024-3205(98)00381-6

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27 July 2017

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