Activated protein C cofactor function of protein S: a critical role for Asp95 in the EGF1-like domain (Q33544143)

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28 January 2020

title

Activated protein C cofactor function of protein S: a critical role for Asp95 in the EGF1-like domain (English)

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28 January 2020

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3

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28 January 2020

Brenda M Luken

4

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28 January 2020

author name string

Helena M Andersson

1

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28 January 2020

Márcia J Arantes

2

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28 January 2020

Sinh Tran

5

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28 January 2020

Björn Dahlbäck

6

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28 January 2020

David A Lane

7

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28 January 2020

Suely M Rezende

8

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28 January 2020

language of work or name

English

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publication date

22 March 2010

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28 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20308596%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

volume

115

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28 January 2020

issue

23

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28 January 2020

page(s)

4878-4885

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Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis

28 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884152

Generation and phenotypic analysis of protein S-deficient mice.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884152

Binding of calcium to anticoagulant protein S: role of the fourth EGF module

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884152

Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884152

The anticoagulant protein C pathway

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884152

The gamma-carboxyglutamic acid domain of anticoagulant protein S is involved in activated protein C cofactor activity, independently of phospholipid binding.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884152

Coagulation, inflammation, and apoptosis: different roles for protein S and the protein S-C4b binding protein complex.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884152

Protein S Gla-domain mutations causing impaired Ca(2+)-induced phospholipid binding and severe functional protein S deficiency

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884152

Conformational changes in activated protein C caused by binding of the first epidermal growth factor-like module of protein S.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884152

Calcium-binding EGF-like modules in coagulation proteinases: function of the calcium ion in module interactions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884152

Relocating the active site of activated protein C eliminates the need for its protein S cofactor. A fluorescence resonance energy transfer study

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884152

Characterization of recombinant epidermal growth factor (EGF)-like modules from vitamin-K-dependent protein S expressed in Spodoptera cells--the cofactor activity depends on the N-terminal EGF module in human protein S.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884152

A theoretical model for the Gla-TSR-EGF-1 region of the anticoagulant cofactor protein S: from biostructural pathology to species-specific cofactor activity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884152

Effects of protein S and factor Xa on peptide bond cleavages during inactivation of factor Va and factor VaR506Q by activated protein C

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884152

Biologically active synthetic fragments of epidermal growth factor: localization of a major receptor-binding region

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884152

A cDNA coding for human sex hormone binding globulin. Homology to vitamin K-dependent protein S.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884152

Isolation and sequence of the cDNA for human protein S, a regulator of blood coagulation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884152

beta-Hydroxyaspartic acid and beta-hydroxyasparagine residues in recombinant human protein S are not required for anticoagulant cofactor activity or for binding to C4b-binding protein

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884152

Characterization of functionally important domains in human vitamin K-dependent protein S using monoclonal antibodies

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884152

Novel APC-cleavage sites in FVa provide insights into mechanisms of action of APC and its cofactor protein S.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884152

Effects of prothrombin on the individual activated protein C-mediated cleavages of coagulation factor Va.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884152

Protein S multimers and monomers each have direct anticoagulant activity

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884152

Importance of protein S and phospholipid for activated protein C-mediated cleavages in factor Va.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884152

Deletion or replacement of the second EGF-like domain of protein S results in loss of APC cofactor activity.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884152

Construction and characterization of thrombin-resistant variants of recombinant human protein S.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884152

Activated protein C cleavage of factor Va leads to dissociation of the A2 domain

31 October 2018

1 reference

12 December 2020

Human protein S cleavage and inactivation by coagulation factor Xa

1 reference

12 December 2020

Amino acid residues in thrombin-sensitive region and first epidermal growth factor domain of vitamin K-dependent protein S determining specificity of the activated protein C cofactor function

1 reference

12 December 2020

Topological studies of the amino terminal modules of vitamin K-dependent protein S using monoclonal antibody epitope mapping and molecular modeling

1 reference

12 December 2020

Inhibition of thrombin generation by protein S at low procoagulant stimuli: implications for maintenance of the hemostatic balance

1 reference

12 December 2020

Molecular bases of type II protein S deficiency: the I203-D204 deletion in the EGF4 domain alters GLA domain function

1 reference

12 December 2020

Protein S multimers are generated in vitro and affect protein S structure-function analyses

1 reference

12 December 2020

The protein S thrombin-sensitive region modulates phospholipid binding and the gamma-carboxyglutamic acid-rich (Gla) domain conformation in a non-specific manner

1 reference

12 December 2020

Regulation of factor VIIIa by human activated protein C and protein S: inactivation of cofactor in the intrinsic factor Xase

1 reference

12 December 2020

Genetic analysis, phenotypic diagnosis, and risk of venous thrombosis in families with inherited deficiencies of protein S

1 reference

12 December 2020

Protein S Thr103Asn mutation associated with type II deficiency reproduced in vitro and functionally characterised

1 reference

12 December 2020

Protein S deficiency: a database of mutations--summary of the first update

1 reference

12 December 2020

Purified protein S contains multimeric forms with increased APC-independent anticoagulant activity

1 reference

12 December 2020

Four missense mutations identified in the protein S gene of thrombosis patients with protein S deficiency: effects on secretion and anticoagulant activity of protein S

1 reference

12 December 2020

Activated protein C-dependent and -independent anticoagulant activities of protein S have different structural requirements

1 reference

12 December 2020

Re-evaluation of the role of the protein S-C4b binding protein complex in activated protein C-catalyzed factor Va-inactivation

1 reference

12 December 2020

Protein S enhances the tissue factor pathway inhibitor inhibition of factor Xa but not its inhibition of factor VIIa-tissue factor

1 reference

12 December 2020

Proteolytic enzymes in coagulation, fibrinolysis, and complement activation. Part A. Mammalian blood coagulation factors and inhibitors

1 reference

12 December 2020

Protein S Tokushima: abnormal molecule with a substitution of Glu for Lys-155 in the second epidermal growth factor-like domain of protein S

1 reference

12 December 2020

In vitro high level protein S expression after modification of protein S cDNA

1 reference

12 December 2020

10.1182/BLOOD-2009-11-256610

Identifiers

DOI

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28 January 2020

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28 January 2020

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