Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist (Q33558075)

28 July 2017

Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist (English)

1 reference

28 July 2017

Nobuyuki Negoro

1

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28 July 2017

Shinobu Sasaki

2

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28 July 2017

Satoshi Mikami

3

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28 July 2017

Masahiro Ito

4

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28 July 2017

Masami Suzuki

5

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28 July 2017

Yoshiyuki Tsujihata

6

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28 July 2017

Ryo Ito

7

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28 July 2017

Ayako Harada

8

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28 July 2017

Koji Takeuchi

9

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28 July 2017

Nobuhiro Suzuki

10

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28 July 2017

Junichi Miyazaki

11

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28 July 2017

Takashi Santou

12

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28 July 2017

Tomoyuki Odani

13

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28 July 2017

Naoyuki Kanzaki

14

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28 July 2017

Miyuki Funami

15

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28 July 2017

Toshimasa Tanaka

16

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28 July 2017

Akifumi Kogame

17

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28 July 2017

Shinichiro Matsunaga

18

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28 July 2017

Tsuneo Yasuma

19

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28 July 2017

Yu Momose

20

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28 July 2017

18 June 2010

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ACS Medicinal Chemistry Letters

28 July 2017

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28 July 2017

1

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28 July 2017

6

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28 July 2017

290-294

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Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research database.

28 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007909

Progress in the discovery and development of small-molecule modulators of G-protein-coupled receptor 40 (GPR40/FFA1/FFAR1): an emerging target for type 2 diabetes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007909

Identification of residues important for agonist recognition and activation in GPR40

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007909

Bidirectional, iterative approach to the structural delineation of the functional "chemoprint" in GPR40 for agonist recognition

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007909

The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007909

Role of GPR40 in fatty acid action on the beta cell line INS-1E.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007909

Oleic acid interacts with GPR40 to induce Ca2+ signaling in rat islet beta-cells: mediation by PLC and L-type Ca2+ channel and link to insulin release

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007909

Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007909

The role of sulphonylureas in the management of type 2 diabetes mellitus

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007909

Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007909

A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007909

The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007909

The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007909

Sulphonylurea-induced hypoglycaemia in type 2 diabetes mellitus: a review

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007909

Fatty acids, lipotoxicity and insulin secretion

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007909

Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007909

A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007909

Sulfonylurea induced beta-cell apoptosis in cultured human islets

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007909

A new genetically obese-hyperglycemic rat (Wistar fatty)

31 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24900210

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ML1000855

1 reference

28 July 2017

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28 July 2017

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