Role of RyR2 phosphorylation in heart failure and arrhythmias: Controversies around ryanodine receptor phosphorylation in cardiac disease (Q33561848)

28 July 2017

title

Role of RyR2 phosphorylation in heart failure and arrhythmias: Controversies around ryanodine receptor phosphorylation in cardiac disease (English)

1 reference

28 July 2017

0 references

0 references

2

Xander H T Wehrens

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28 July 2017

1

Dobromir Dobrev

1 reference

28 July 2017

publication date

1 April 2014

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28 July 2017

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28 July 2017

volume

114

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28 July 2017

issue

8

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28 July 2017

page(s)

1311-9; discussion 1319

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Nitric oxide-dependent activation of CaMKII increases diastolic sarcoplasmic reticulum calcium release in cardiac myocytes in response to adrenergic stimulation

28 July 2017

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Inhibition of CaMKII phosphorylation of RyR2 prevents inducible ventricular arrhythmias in mice with Duchenne muscular dystrophy.

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Calcium leak through ryanodine receptors leads to atrial fibrillation in 3 mouse models of catecholaminergic polymorphic ventricular tachycardia.

21 June 2018

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Ryanodine receptor phosphorylation and heart failure: phasing out S2808 and "criminalizing" S2814.

21 June 2018

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Ryanodine receptor phosphorylation, calcium/calmodulin-dependent protein kinase II, and life-threatening ventricular arrhythmias

21 June 2018

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Role of RyR2 phosphorylation at S2814 during heart failure progression

21 June 2018

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PKA phosphorylation of cardiac ryanodine receptor modulates SR luminal Ca2+ sensitivity

21 June 2018

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Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation

21 June 2018

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Circadian rhythms govern cardiac repolarization and arrhythmogenesis

21 June 2018

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Hyperphosphorylation of the cardiac ryanodine receptor at serine 2808 is not involved in cardiac dysfunction after myocardial infarction

21 June 2018

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MicroRNA-1 and -133 increase arrhythmogenesis in heart failure by dissociating phosphatase activity from RyR2 complex

21 June 2018

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Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial fibrillation in FKBP12.6 knockout mice

21 June 2018

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Oxidation of CaMKII determines the cardiotoxic effects of aldosterone.

21 June 2018

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Calcium-calmodulin dependent protein kinase II (CaMKII): a main signal responsible for early reperfusion arrhythmias

21 June 2018

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Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging.

21 June 2018

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Effects of isoflurane anesthesia on the cardiovascular function of the C57BL/6 mouse

21 June 2018

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Targeting ryanodine receptors for anti-arrhythmic therapy

21 June 2018

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Inherited dysfunction of sarcoplasmic reticulum Ca2+ handling and arrhythmogenesis

21 June 2018

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Is ryanodine receptor phosphorylation key to the fight or flight response and heart failure?

21 June 2018

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Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice

21 June 2018

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Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice

21 June 2018

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Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure

21 June 2018

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Exercise training and caloric restriction prevent reduction in cardiac Ca2+-handling protein profile in obese rats

21 June 2018

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Impaired S-nitrosylation of the ryanodine receptor caused by xanthine oxidase activity contributes to calcium leak in heart failure

21 June 2018

1 reference

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Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy

21 June 2018

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Ca sparks do not explain all ryanodine receptor-mediated SR Ca leak in mouse ventricular myocytes

21 June 2018

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Role of CaMKIIdelta phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failure

21 June 2018

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Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor.

21 June 2018

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Ryanodine receptor studies using genetically engineered mice

21 June 2018

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cAMP-stimulated protein phosphatase 2A activity associated with muscle A kinase-anchoring protein (mAKAP) signaling complexes inhibits the phosphorylation and activity of the cAMP-specific phosphodiesterase PDE4D3.

21 June 2018

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Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy

21 June 2018

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Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging

21 June 2018

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Atrial remodeling and atrial fibrillation: mechanisms and implications.

21 June 2018

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Ryanodine receptors are regulated by the circadian clock and implicated in gating photic entrainment

21 June 2018

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Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice

21 June 2018

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Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice.

21 June 2018

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Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans

21 June 2018

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miR-1 overexpression enhances Ca(2+) release and promotes cardiac arrhythmogenesis by targeting PP2A regulatory subunit B56alpha and causing CaMKII-dependent hyperphosphorylation of RyR2

21 June 2018

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Ryanodine receptor phosphorylation at Serine 2030, 2808 and 2814 in rat cardiomyocytes.

21 June 2018

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Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation.

21 June 2018

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Adrenergic regulation of cardiac contractility does not involve phosphorylation of the cardiac ryanodine receptor at serine 2808

21 June 2018

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21 June 2018

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Loss of luminal Ca2+ activation in the cardiac ryanodine receptor is associated with ventricular fibrillation and sudden death

21 June 2018

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21 June 2018

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Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy.

21 June 2018

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Ser-2030, but not Ser-2808, is the major phosphorylation site in cardiac ryanodine receptors responding to protein kinase A activation upon beta-adrenergic stimulation in normal and failing hearts.

21 June 2018

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Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression

21 June 2018

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Enhanced store overload-induced Ca2+ release and channel sensitivity to luminal Ca2+ activation are common defects of RyR2 mutations linked to ventricular tachycardia and sudden death

21 June 2018

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Ryanodine receptor-targeted anti-arrhythmic therapy

21 June 2018

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Intracellular calcium release and cardiac disease

21 June 2018

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Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak

21 June 2018

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21 June 2018

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Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2.

21 June 2018

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Cellular basis of triggered arrhythmias in heart failure

21 June 2018

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Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor

21 June 2018

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Characterization of Recombinant Skeletal Muscle (Ser-2843) and Cardiac Muscle (Ser-2809) Ryanodine Receptor Phosphorylation Mutants

21 June 2018

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FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death

21 June 2018

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The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure

21 June 2018

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Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release

21 June 2018

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Regulation of ryanodine receptors via macromolecular complexes: a novel role for leucine/isoleucine zippers

21 June 2018

1 reference

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Involvement of the cardiac ryanodine receptor/calcium release channel in catecholaminergic polymorphic ventricular tachycardia

21 June 2018

1 reference

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Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia

21 June 2018

1 reference

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Mutations of the cardiac ryanodine receptor (RyR2) gene in familial polymorphic ventricular tachycardia

21 June 2018

1 reference

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PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts

21 June 2018

1 reference

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Unique phosphorylation site on the cardiac ryanodine receptor regulates calcium channel activity.

21 June 2018

1 reference

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Genetic ablation of ryanodine receptor 2 phosphorylation at Ser-2808 aggravates Ca(2+)-dependent cardiomyopathy by exacerbating diastolic Ca2+ release.

21 June 2018

1 reference

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Ca2+/calmodulin-dependent protein kinase II and protein kinase A differentially regulate sarcoplasmic reticulum Ca2+ leak in human cardiac pathology.

31 October 2018

1 reference

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Single cell and subcellular measurements of intracellular Ca²⁺ concentration

31 October 2018

1 reference

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Ryanodine receptor S2808 phosphorylation in heart failure: smoking gun or red herring.

31 October 2018

1 reference

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Overexpression of cAMP-response element modulator causes abnormal growth and development of the atrial myocardium resulting in a substrate for sustained atrial fibrillation in mice

31 October 2018

1 reference

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A novel ryanodine receptor mutation linked to sudden death increases sensitivity to cytosolic calcium.

31 October 2018

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31 October 2018

1 reference

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Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation.

31 October 2018

1 reference

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CaMKII-dependent diastolic SR Ca2+ leak and elevated diastolic Ca2+ levels in right atrial myocardium of patients with atrial fibrillation

31 October 2018

1 reference

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Distinct contractile and molecular differences between two goat models of atrial dysfunction: AV block-induced atrial dilatation and atrial fibrillation

31 October 2018

1 reference

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Phosphatase inhibitor-1-deficient mice are protected from catecholamine-induced arrhythmias and myocardial hypertrophy

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008932

Comparing isoflurane with tribromoethanol anesthesia for echocardiographic phenotyping of transgenic mice.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008932

Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008932

Spontaneous diastolic contractions and phosphorylation of the cardiac ryanodine receptor at serine-2808 in congestive heart failure in rat.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008932

Defective cardiac ryanodine receptor regulation during atrial fibrillation

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008932

Atrial fibrillation is associated with increased spontaneous calcium release from the sarcoplasmic reticulum in human atrial myocytes

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008932

Sparking the failing heart

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008932

Stoichiometric phosphorylation of cardiac ryanodine receptor on serine 2809 by calmodulin-dependent kinase II and protein kinase A.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008932

Elevated sarcoplasmic reticulum Ca2+ leak in intact ventricular myocytes from rabbits in heart failure

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008932

Protein phosphatases decrease sarcoplasmic reticulum calcium content by stimulating calcium release in cardiac myocytes

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008932

Calmodulin kinase II and arrhythmias in a mouse model of cardiac hypertrophy

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008932

Protein kinase A phosphorylation of the ryanodine receptor does not affect calcium sparks in mouse ventricular myocytes

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008932

beta-adrenergic receptor blockers restore cardiac calcium release channel (ryanodine receptor) structure and function in heart failure

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4008932

Solubilization, partial purification and functional reconstitution of a sheep brain endoplasmic reticulum anion channel

31 October 2018

1 reference

12 December 2020

Calmodulin kinase II inhibition protects against structural heart disease

1 reference

12 December 2020

Maximum phosphorylation of the cardiac ryanodine receptor at serine-2809 by protein kinase a produces unique modifications to channel gating and conductance not observed at lower levels of phosphorylation

1 reference

12 December 2020

Molecular determinants of altered Ca2+ handling in human chronic atrial fibrillation

1 reference

12 December 2020

Intact beta-adrenergic response and unmodified progression toward heart failure in mice with genetic ablation of a major protein kinase A phosphorylation site in the cardiac ryanodine receptor

1 reference

12 December 2020

10.1161/CIRCRESAHA.114.300568

Identifiers

DOI

1 reference

release_xmefkoarc5g7rgyi3wudkwldoy

28 July 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/xmefkoarc5g7rgyi3wudkwldoy

24 November 2022

mapped directly with Wikidata item

PMC publication ID

4008932

1 reference

28 July 2017

1 reference